HYDROXYALKYL STARCH IN COMBINATION WITH CYTOSTATICA FOR THE TREATMENT OF CANCERS BY REDUCTION OF TUMOR GROWTH RATES
    3.
    发明申请
    HYDROXYALKYL STARCH IN COMBINATION WITH CYTOSTATICA FOR THE TREATMENT OF CANCERS BY REDUCTION OF TUMOR GROWTH RATES 审中-公开
    通过减少肿瘤生长速率与CYCOSTAATA联合治疗癌症的羟丙基淀粉

    公开(公告)号:WO2013113496A1

    公开(公告)日:2013-08-08

    申请号:PCT/EP2013/000276

    申请日:2013-01-30

    摘要: The present invention relates to hydroxyalkyl starch or a pharmaceutical preparation thereof for the treatment of cancer, tumor or tumor associated diseases, especially by effectively reducing tumor growth rate and inhibiting tumor growth and wherein the hydroxyalkyl starch has a mean molecular weight (MW) above 20 and below 1300 kDa and a molar substitution (MS) in the range of from 0.1 to 1.5, wherein the alkylation may be an ethylation, propylation or butylation or mixes thereof; and wherein the alkyl may be further substituted.

    摘要翻译: 本发明涉及用于治疗癌症,肿瘤或肿瘤相关疾病的羟烷基淀粉或其药物制剂,特别是通过有效降低肿瘤生长速率和抑制肿瘤生长,其中羟烷基淀粉的平均分子量(MW)高于20 和低于1300kDa,摩尔取代度(MS)在0.1至1.5的范围内,其中烷基化可以是乙基化,丙基化或丁基化或其混合物; 并且其中所述烷基可以进一步被取代。

    METHOD FOR MANUFACTURING HYDROXYETHYL STARCH DERIVATIVES
    4.
    发明申请
    METHOD FOR MANUFACTURING HYDROXYETHYL STARCH DERIVATIVES 审中-公开
    制备羟基乙酰淀粉衍生物的方法

    公开(公告)号:WO2012175608A1

    公开(公告)日:2012-12-27

    申请号:PCT/EP2012/061958

    申请日:2012-06-21

    摘要: The invention relates to a method for manufacturing a modified hydroxyethyl starch carrying a heptonic acid residue on at least one of its termini. According to the invention, the following steps are carried out: a) dissolving hydroxyethyl starch in water, b) adjusting the p H value to a value of 8.0 to 10.0, c) adding a cyanide compound to the hydroxyethyl starch solution, heating the solution to a temperature of 80 to 99 ° C and keeping it at this temperature for a first time period, and d) adjusting the p H value to a value of 2.0 to 4.0, bringing the solution to a temperature of 50 to 90 ° C and keeping it at this temperature for a second time period.

    摘要翻译: 本发明涉及在其至少一个末端上制备带有庚糖残基的改性羟乙基淀粉的方法。 根据本发明,进行以下步骤:a)将羟乙基淀粉溶于水中,b)将p H值调节至8.0至10.0,c)将氰化物化合物加入到羟乙基淀粉溶液中,加热溶液 温度为80〜99℃,在该温度下保持第一时间,d)将p H值调整为2.0〜4.0,使溶液达到50〜90℃的温度, 在此温度下保持第二个时间。

    METHOD FOR PREPARING HYDROXYALKYL STARCH
    5.
    发明申请
    METHOD FOR PREPARING HYDROXYALKYL STARCH 审中-公开
    制备羟基烷基淀粉的方法

    公开(公告)号:WO2012091298A1

    公开(公告)日:2012-07-05

    申请号:PCT/KR2011/008984

    申请日:2011-11-23

    IPC分类号: C08B31/10 C08B30/12

    CPC分类号: C08B31/10 C08B30/12 C08B31/12

    摘要: The present invention relates to a method for preparing hydroxyalkyl starch. The method for preparing hydroxyalkyl starch comprises the steps of hydrolyzing starch, reducing the hydrolyzed starch, and substituting the reduced starch with hydroxyalkyl group in a dry process.

    摘要翻译: 本发明涉及一种制备羟烷基淀粉的方法。 制备羟烷基淀粉的方法包括水解淀粉,还原水解淀粉以及在干法中用羟基烷基取代还原淀粉的步骤。

    PROCESS USING HYDROCLONES
    8.
    发明申请
    PROCESS USING HYDROCLONES 审中-公开
    使用氢化物​​的方法

    公开(公告)号:WO2010066368A1

    公开(公告)日:2010-06-17

    申请号:PCT/EP2009/008580

    申请日:2009-12-02

    IPC分类号: C08B30/04 C08B31/04

    CPC分类号: C08B31/00 C08B31/12

    摘要: The present invention concerns a process for preparing of slurries containing suspended and dissolved particles and a solution as well as a slurry are provided onto a hydrocyclone equipment, disk centrifuge or nozzle centrifuge equipment. The dry matter concentration in the collected slurry is higher than the concentration of the mixture of the slurry and the solution as such. The use of a hydrocyclone stage for this specific purpose is disclosed as well.

    摘要翻译: 本发明涉及一种制备含有悬浮和溶解的颗粒的浆料的方法,并且将溶液以及浆料提供到水力旋流器设备,盘式离心机或喷嘴离心机设备上。 收集的浆料中的干物质浓度高于浆液和溶液的混合物的浓度。 还公开了用于该特定目的的水力旋流器级的使用。

    STARCH ETHERIFICATION METHOD
    9.
    发明申请
    STARCH ETHERIFICATION METHOD 审中-公开
    STARCH循环方法

    公开(公告)号:WO2007006848A1

    公开(公告)日:2007-01-18

    申请号:PCT/FI2006/000248

    申请日:2006-07-12

    IPC分类号: C08B31/08

    摘要: The invention relates to a method for preparing a starch ether. The method comprises mixing cellulose with an ionic liquid solvent to dissolve the starch, and then treating the dissolved starch with an etherifying agent in the presence of a base to form a starch ether, and subsequently separating the starch ether from the solution, wherein both the dissolution and the etherification are carried out in the substantial absence of water.

    摘要翻译: 本发明涉及淀粉醚的制备方法。 该方法包括将纤维素与离子液体溶剂混合以溶解淀粉,然后在碱存在下用醚化剂处理溶解的淀粉以形成淀粉醚,随后将淀粉醚与溶液分离,其中 溶解和醚化在基本上不存在水的情况下进行。