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    METHOD AND APPARATUS FOR BOOSTING VACCINE EFFICACY
    2.
    发明申请
    METHOD AND APPARATUS FOR BOOSTING VACCINE EFFICACY 审中-公开
    用于提高疫苗效能的方法和装置

    公开(公告)号：WO2014151403A1

    公开(公告)日：2014-09-25

    申请号：PCT/US2014025659

    申请日：2014-03-13

    Applicant: GEN HOSPITAL CORP ,  WU MEI X ,  ANDERSON R REX

    Inventor： WU MEI X ,  ANDERSON R REX

    IPC: A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61K39/13 ,  A61K39/145 ,  A61K39/165 ,  A61K39/20 ,  A61K39/29 ,  A61N5/067 ,  A61N7/02

    CPC classification number: A61K41/0052 ,  A61B2018/143 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/55511 ,  A61K2039/55588 ,  A61M37/0092 ,  A61M2037/0007 ,  A61M2202/30 ,  A61N5/0625 ,  A61N7/02 ,  C12N2760/16111 ,  C12N2760/16134

    Abstract: A method and an system for vaccinating a mammalian subject. The method includes the steps of: arranging a source of electromagnetic radiation proximate to a target zone of skin of the mammalian subject; controlling the source of electromagnetic radiation to deliver a dose of electromagnetic radiation to the target zone determined to create one or more thermally-denatured zones in the target zone; and intradermally injecting a vaccine within the target zone to vaccinate the mammalian subject. The system for vaccinating a subject may include an electromagnetic radiation source configured to be arranged proximate to a target zone on an exterior of the subject; a user control configured to selectively cause the electromagnetic radiation source to deliver a dose of electromagnetic radiation toward the target zone to create one or more thermally-denatured zones in the target zone; and a vaccine-delivery system configured to deliver a vaccine to the target zone.

    Abstract translation: 哺乳动物受试者接种疫苗的方法和系统。 该方法包括以下步骤：将电磁辐射源布置在哺乳动物受试者的皮肤目标区域附近; 控制电磁辐射源以将一定剂量的电磁辐射输送到被确定为在目标区域中产生一个或多个热变性区域的目标区域; 并在靶区内皮内注射疫苗以接种哺乳动物受试者。 用于接种受试者的系统可以包括被配置为被布置成靠近对象外部的目标区域的电磁辐射源; 用户控制被配置为选择性地使所述电磁辐射源向所述目标区域递送一定剂量的电磁辐射，以在所述目标区域中产生一个或多个热变性区域; 以及配置用于将疫苗递送至目标区域的疫苗递送系统。

    DOUBLE-STRANDED RNA
    3.
    发明申请
    DOUBLE-STRANDED RNA 审中-公开
    双链RNA

    公开(公告)号：WO2014138792A1

    公开(公告)日：2014-09-18

    申请号：PCT/AU2014/000251

    申请日：2014-03-13

    Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION ,  MAT MALTA ADVANCED TECHNOLOGIES LIMITED

    Inventor： DORAN, Timothy James ,  TYACK, Scott Geoffrey ,  JENKINS, Kristie A

    IPC: C12N15/113 ,  C12N15/44

    CPC classification number: C12N15/1131 ,  A01K67/0275 ,  A01K2227/30 ,  C12N2310/14 ,  C12N2760/16111

    Abstract: The present invention relates to nucleic acid molecules comprising a double stranded region complementary to a target gene of an influenza virus, in particular dsRNA fragments specific for the NSI and NEP (NS2) genes. The mvention further relates to expression vectors, cells, compositions and transgenic non-human mammals and avians comprising the polynucleotides, as well as methods of treating or preventing influenza in a subject by administering the polynucleotide, vector, cell or composition to the subject.

    Abstract translation: 本发明涉及包含与流感病毒的靶基因互补的双链区域，特别是NSI和NEP（NS2）基因特异性的dsRNA片段的核酸分子。 本发明还涉及包含多核苷酸的表达载体，细胞，组合物和转基因非人哺乳动物和鸟类，以及通过向受试者施用多核苷酸，载体，细胞或组合物来治疗或预防受试者中的流感的方法。

    RESPIRATORY SYNCYTIAL VIRUS RENDERS DENDRITIC CELLS TOLEROGENIC
    9.
    发明申请
    RESPIRATORY SYNCYTIAL VIRUS RENDERS DENDRITIC CELLS TOLEROGENIC 审中-公开
    呼吸道同类病毒Renders DENDRITIC CELLS TOLEROGENIC

    公开(公告)号：WO2009149397A3

    公开(公告)日：2010-03-25

    申请号：PCT/US2009046482

    申请日：2009-06-05

    Applicant: BAYLOR RES INST ,  CONNOLLY JOHN E ,  BANCHEREAU JACQUES F ,  GILL MICHELLE A

    Inventor： CONNOLLY JOHN E ,  BANCHEREAU JACQUES F ,  GILL MICHELLE A

    IPC: A61K39/12 ,  A61P3/10 ,  A61P19/02 ,  A61P31/12

    CPC classification number: A61K39/001 ,  A61K2035/122 ,  A61K2039/5154 ,  C12N5/064 ,  C12N2760/16111 ,  C12N2760/18511

    Abstract: The present invention includes compositions, methods and systems for inducing immune tolerance using antigen presenting cells by infecting isolated antigen presenting cells with an effective amount of respiratory syncytial virus (RSV) or portions thereof sufficient to infect the antigen presenting cells and contacting CD4+, CD8+ or both CD4+ T cells and CD8+ T cells with the RSV-infected antigen presenting cells, wherein the CD4+, CD8+ or both CD4 and CD8+ T cells are rendered tolerogenic as measured in vitro by a mixed leukocyte reaction.

    Abstract translation: 本发明包括用抗原呈递细胞诱导免疫耐受的组合物，方法和系统，其通过用有效量的呼吸道合胞病毒（RSV）或其部分感染分离的抗原呈递细胞，其足以感染抗原呈递细胞并接触CD4 +，CD8 +或 具有RSV感染的抗原呈递细胞的CD4 + T细胞和CD8 + T细胞都是CD4 +，CD8 +或CD4 + CD8 + T细胞都具有耐受性，通过混合白细胞反应体外测定。

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