公开(公告)号：WO2019060672A1

公开(公告)日：2019-03-28

申请号：PCT/US2018/052148

申请日：2018-09-21

Applicant: MODERN MEADOW, INC.

Inventor： DAI, Lixin ,  SRIVASTAVA, Poonam

IPC: C07K14/78 ,  C14C13/00 ,  C12P21/00 ,  C07K14/435

CPC classification number: C07K14/78 ,  C07K14/195 ,  C07K14/245 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/0071 ,  C12N9/1205 ,  C12N9/1241 ,  C12N9/18 ,  C12N9/90 ,  C12N15/815 ,  C12R1/84 ,  C12Y101/01019 ,  C12Y101/0102 ,  C12Y101/01022 ,  C12Y103/03012 ,  C12Y114/11004 ,  C12Y207/01001 ,  C12Y207/01043 ,  C12Y207/07009 ,  C12Y207/07044 ,  C12Y207/07069 ,  C12Y301/01017 ,  C12Y301/01019 ,  C12Y301/03025 ,  C12Y501/03018 ,  C12Y504/02002 ,  D01F1/02 ,  D01F4/00

Abstract: This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.