グリシン繰り返し配列タンパク質を産生する形質転換体
    1.
    发明申请
    グリシン繰り返し配列タンパク質を産生する形質転換体 审中-公开
    生产甘油重复蛋白的转化体

    公开(公告)号:WO2011115070A1

    公开(公告)日:2011-09-22

    申请号:PCT/JP2011/055960

    申请日:2011-03-14

    Inventor: 西尾 昌一

    Abstract:  下記(1)~(3)の全てのタンパク質のアミノ酸配列をコードする塩基配列を有するポリヌクレオチドが微生物細胞内に導入されて得られることを特徴とする形質転換体等。 (1)FK506に結合性を有し、且つ、分子量1万5千以上、6万以下であるFK506タンパク質 (2)プロリン水酸化酵素 (3)下記の特性(A)及び(B)を有するグリシン繰り返し配列タンパク質 <特性(A)> グリシン繰り返し配列タンパク質におけるポリペプチド鎖が、連続するGly-Xaa-Yaa の繰り返し配列を有する。 <特性(B)> グリシン繰り返し配列タンパク質におけるポリペプチド鎖の連続するGly-Xaa-Yaa の繰り返し配列にイミノ酸が含まれている。

    Abstract translation: 公开了转化体,其特征在于通过将包含编码下述所有蛋白质(1) - (3)的氨基酸序列的核苷酸序列的多核苷酸引入微生物细胞而获得。 (1)具有以下特征(A)和(B)的甘氨酸重复蛋白质的能够结合FK 506并且分子量为15,000-60,000(含)的FK 506蛋白质(2)脯氨酸羟化酶(3) )特征(A)>甘氨酸重复蛋白中的多肽链具有连续的Gly-Xaa-Yaa重复序列。 甘氨酸重复蛋白中的多肽链的连续Gly-Xaa-Yaa重复序列的特征(B)各自含有亚氨酸

    A NEW PHARMACEUTICAL PRODUCT
    3.
    发明申请
    A NEW PHARMACEUTICAL PRODUCT 审中-公开
    一种新的药用产品

    公开(公告)号:WO2010049590A2

    公开(公告)日:2010-05-06

    申请号:PCT/FI2009/050869

    申请日:2009-10-29

    Abstract: The present invention relates to methods and products for the treatment of any disorder or condition, which is associated with abnormal amount of non-collagenous protein, or abnormal oligomerization or dysfunction of non-collagenous protein, such as adiponectin in the blood circulation and/or tissue of a patient. The treatment comprises that functional form of the non-collagenous protein is adjusted in the blood circulation and/or tissue of the patient substantially to the level it is in the blood circulation and/or tissue of a healthy person, by using lysyl hydroxylase and/or glycosyl- transferase activities of LH3 or other lysyl hydroxylase to modify the non-collagenous protein to HMW or other functional form.

    Abstract translation: 本发明涉及用于治疗与非胶原蛋白异常量相关的任何障碍或病症的方法和产品,或非胶原性蛋白质如血液循环中的脂联素的异常低聚或功能障碍和/或 患者的组织。 该治疗包括通过使用赖氨酰羟化酶和/或抗体,将非胶原蛋白的功能形式在患者的血液循环和/或组织中基本上调节至其在血液循环和/或健康人的组织中的水平, 或LH3或其他赖氨酰羟化酶的糖基转移酶活性,将非胶原蛋白修饰为HMW或其他功能形式。

    PRODUCTS AND METHODS AFFECTING CELL AND TISSUE GROWTH
    4.
    发明申请
    PRODUCTS AND METHODS AFFECTING CELL AND TISSUE GROWTH 审中-公开
    影响细胞和组织生长的产品和方法

    公开(公告)号:WO2009080899A3

    公开(公告)日:2009-10-01

    申请号:PCT/FI2008050786

    申请日:2008-12-22

    CPC classification number: C12Y114/11004 A61K38/00 C12N9/0071 G01N2333/9015

    Abstract: The present invention relates to new products, and methods, which can be used in regulating cell and tissue growth. In particular, the present invention relates to new products, and methods, which can be used for improving cell or tissue growth. According to the method, glycosyltransferase activity in cell or tissue culture or growth system is increased, said glycosyltransferase activity being the glycosyltransferase activity of lysyl hydroxylase 3 (LH3) or LH enzyme capable of glycosylating hydroxylysine residues. By means of the i cell or tissue growth in cell or tissue cultures or in human or animal body can be regulated and cell growth of, for example, nerve cells, can be improved.

    Abstract translation: 本发明涉及可用于调节细胞和组织生长的新产品和方法。 具体而言,本发明涉及可用于改善细胞或组织生长的新产品和方法。 根据该方法,细胞或​​组织培养物或生长系统中的糖基转移酶活性增加,所述糖基转移酶活性是能够使羟赖氨酸残基糖基化的赖氨酰羟化酶3(​​LH3)或LH酶的糖基转移酶活性。 通过i细胞或组织在细胞或组织培养物中或在人体或动物体内的生长可以被调控,并且例如神经细胞的细胞生长可以得到改善。

    PRODUCTS AND METHODS AFFECTING CELL AND TISSUE GROWTH
    8.
    发明申请
    PRODUCTS AND METHODS AFFECTING CELL AND TISSUE GROWTH 审中-公开
    影响细胞和组织生长的产物和方法

    公开(公告)号:WO2009080899A2

    公开(公告)日:2009-07-02

    申请号:PCT/FI2008/050786

    申请日:2008-12-22

    CPC classification number: C12Y114/11004 A61K38/00 C12N9/0071 G01N2333/9015

    Abstract: The present invention relates to new products, and methods, which can be used in regulating cell and tissue growth. In particular, the present invention relates to new products, and methods, which can be used for improving cell or tissue growth. According to the method, glycosyltransferase activity in cell or tissue culture or growth system is increased, said glycosyltransferase activity being the glycosyltransferase activity of lysyl hydroxylase 3 (LH3) or LH enzyme capable of glycosylating hydroxylysine residues. By means of the i cell or tissue growth in cell or tissue cultures or in human or animal body can be regulated and cell growth of, for example, nerve cells, can be improved.

    Abstract translation: 本发明涉及可用于调节细胞和组织生长的新产品和方法。 特别地,本发明涉及可用于改善细胞或组织生长的新产品和方法。 根据该方法,细胞或​​组织培养或生长系统中的糖基转移酶活性增加,所述糖基转移酶活性是能够糖基化羟赖氨酸残基的赖氨酰羟化酶3(​​LH3)或LH酶的糖基转移酶活性。 通过i细胞或细胞或组织培养物或人体或动物体内的组织生长,可以调节细胞,例如神经细胞的细胞生长。

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