Abstract:
A correlation between expression of JMJD6 polypeptide and breast cancer metastasis exists accordingly the present invention relates a diagnostic, prognostic and therapeutic biomarker to distinguish between early and advanced/metastatic cancer particularly breast cancer, including compounds and methods to treat the same.
Abstract:
The present invention relates to methods and products for the treatment of any disorder or condition, which is associated with abnormal amount of non-collagenous protein, or abnormal oligomerization or dysfunction of non-collagenous protein, such as adiponectin in the blood circulation and/or tissue of a patient. The treatment comprises that functional form of the non-collagenous protein is adjusted in the blood circulation and/or tissue of the patient substantially to the level it is in the blood circulation and/or tissue of a healthy person, by using lysyl hydroxylase and/or glycosyl- transferase activities of LH3 or other lysyl hydroxylase to modify the non-collagenous protein to HMW or other functional form.
Abstract:
The present invention relates to new products, and methods, which can be used in regulating cell and tissue growth. In particular, the present invention relates to new products, and methods, which can be used for improving cell or tissue growth. According to the method, glycosyltransferase activity in cell or tissue culture or growth system is increased, said glycosyltransferase activity being the glycosyltransferase activity of lysyl hydroxylase 3 (LH3) or LH enzyme capable of glycosylating hydroxylysine residues. By means of the i cell or tissue growth in cell or tissue cultures or in human or animal body can be regulated and cell growth of, for example, nerve cells, can be improved.
Abstract:
The present invention relates to products and methods, which can be used for preventing tumour growth. Lysylhydroxylase enzyme, LH3 or LH or fragments thereof being essentially deficient of glycosyltransferase activity, or nucleotide sequences encoding said enzymes or fragments thereof, can be used to prevent tumour growth.
Abstract:
The present invention relates to new products, and methods, which can be used in regulating cell and tissue growth. In particular, the present invention relates to new products, and methods, which can be used for improving cell or tissue growth. According to the method, glycosyltransferase activity in cell or tissue culture or growth system is increased, said glycosyltransferase activity being the glycosyltransferase activity of lysyl hydroxylase 3 (LH3) or LH enzyme capable of glycosylating hydroxylysine residues. By means of the i cell or tissue growth in cell or tissue cultures or in human or animal body can be regulated and cell growth of, for example, nerve cells, can be improved.
Abstract:
This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.