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    PROCESS FOR PRODUCING VINYLGLYCINE DERIVATIVES
    3.
    发明申请
    PROCESS FOR PRODUCING VINYLGLYCINE DERIVATIVES 审中-公开
    生产乙烯基衍生物的方法

    公开(公告)号：WO2012036302A1

    公开(公告)日：2012-03-22

    申请号：PCT/JP2011/071543

    申请日：2011-09-14

    申请人： SUMITOMO CHEMICAL COMPANY, LIMITED ,  KAWABE, Tomoyasu ,  KUDOU, Daizo

    发明人： KAWABE, Tomoyasu ,  KUDOU, Daizo

    IPC分类号： C12P13/04 ,  C12N15/09

    CPC分类号： C12Y104/01004 ,  C12P13/04 ,  C12Y104/01001 ,  C12Y104/01009 ,  C12Y104/0102

    摘要： The present invention provides a process for producing a vinylglycine derivative represented by the formula (2): wherein R 1 represents hydrogen, an alkyl group having 1 to 8 carbon atoms, or an aryl group having 6 to 20 carbon atoms; or a salt thereof comprising a step of reacting in the presence of an ammonium salt compound and a cofactor a vinyl glyoxylic acid represented by the formula (1): wherein R 1 is the same as defined above; or a salt thereof with an amino acid dehydrogenase, a culture of a microorganism capable of producing an amino acid dehydrogenase or a processed product of the culture, etc.

    摘要翻译： 本发明提供一种制备由式（2）表示的乙烯基甘氨酸衍生物的方法：其中R1表示氢，具有1至8个碳原子的烷基或具有6至20个碳原子的芳基; 或其盐，其包括在铵盐化合物和辅助因子存在下使由式（1）表示的乙烯基乙醛酸反应的步骤：其中R1与上述定义相同; 或其与氨基酸脱氢酶的盐，能够产生氨基酸脱氢酶的微生物培养物或培养物的加工产物等。

    REDOX SELF-SUFFICIENT BIOCATALYTIC AMINATION OF ALCOHOLS
    4.
    发明申请
    REDOX SELF-SUFFICIENT BIOCATALYTIC AMINATION OF ALCOHOLS 审中-公开
    REDOX自发生物生物化学胺化

    公开(公告)号：WO2016001362A1

    公开(公告)日：2016-01-07

    申请号：PCT/EP2015/065101

    申请日：2015-07-02

    申请人： BASF SE

    发明人： BALDENIUS, Kai-Uwe ,  BREUER, Michael ,  DITRICH, Klaus ,  NAVICKAS, Vaidotas ,  MUTTI, Francesco ,  KNAUS, Tanja ,  TURNER, Nicholas

    IPC分类号： C12P13/00 ,  C12N9/06

    CPC分类号： C12P13/001 ,  C12N9/0006 ,  C12N9/0016 ,  C12N9/0018 ,  C12Y101/01001 ,  C12Y104/01009 ,  C12Y104/0102

    摘要： The present invention relates to a novel biocatalytic method for the production of primary and secondary amines, comprising coupled enzymatic oxidation and reduction processes simultaneously regenerating the required cofactor; making use of two enzymes - i.e. an alcohol dehydrogenase and an amine dehydrogenase - operating simultaneously in a one pot process (i.e. biocatalytic cascade). Furthermore, the overall process is redox neutral, since the hydride generated from the first oxidative step is internally recycled in the second reductive step. The invention also relates to recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods.

    摘要翻译： 本发明涉及一种用于生产伯胺和仲胺的新型生物催化方法，其包括同时再生所需辅因子的偶联酶氧化和还原方法; 利用在一锅法（即生物催化级联）中同时操作的两种酶即醇脱氢酶和胺脱氢酶。 此外，总体方法是氧化还原中性，因为从第一氧化步骤产生的氢化物在第二还原步骤中被内部再循环。 本发明还涉及获得所需酶活性的重组表达系统和微生物; 和用于执行这种方法的生物反应器。