Abstract:
The present invention is a method for preparing micron-sized or submicron-sized drug particles comprising contacting a solution comprising a poorly water soluble drug substance and at least one freezable organic solvent with a cold surface so as to freeze the solution; and removing the organic solvent. The resulting particles are also disclosed, as are several embodiments of an apparatus that can be used in performing the method of the present invention.
Abstract:
The present disclosure provides for a continuous drying apparatus and a method of using the apparatus in the preparation of dried solids from slurries. The methods and apparatus are useful for the production of fine chemicals and pharmaceuticals, particularly using Integrated Continuous Manufacturing (ICM), but can also be integrated with other manufacturing processes, such as batch and semi-continuous processes.
Abstract:
A method for discharging vapor from a roller dryer (1), comprising: collecting vapor rising from a roller dryer in a dome (3) placed over a vapor release area (2) of the roller dryer, passing the vapor from the dome to the condenser (9), and condensing supplied vapor in the condenser. Also described is an apparatus for discharging vapor from a roller dryer, comprising a dome to be placed over a vapor release area of a roller dryer, having a collecting space (6) surrounded by a shell of the dome for collecting vapor rising from the roller dryer, and a condenser in flow connection with the dome for therein condensing vapor obtained from the collecting space.
Abstract:
A double drum arrangement (1) comprising a frame adjustment mechanism (11) to adjust the second frame (3) with respect to the first frame (2) for adapting the gap (8) between the first drum (4) and the second drum (5), wherein the frame adjustment mechanism (11) comprises a robust adjustment mechanism (13) for adapting the gap (8) within a predetermined robust tolerance and a precise adjustment mechanism (14) for adapting the gap (8) within a predetermined precise tolerance, wherein the precise tolerance is smaller than the robust tolerance. Further, an adjustable end stop (23) is provided.
Abstract:
A microwave rotary film concentrator comprises an enclosed tank (1), a rotary evaporator (2), a microwave device (3), a discharge pipe for concentrated liquid (5), a condensor (6), a microwave shielding device (7), a stirring motor (8) and a vacuum system. The evaporating surface of the rotary evaporator (2) is tapered or round shaped. The angle (a) between the axis and the horizontal plane is 0 to 90°. The rotary evaporator (2) indirectly connects to the external stirring motor (8) through a magnetic stirring device, and locates in the center of the enclosed tank (1). The enclosed tank (1) is provided with a lid which can be opened or closed. A sight glass (9) is on the lid. This invention has resolved many problems in concentration of the extracting liquid, such as slow evaporation rate, high concentration temperature, feed liquid decomposition due to be heated for a long time, unable to operate in reduced pressure as a result of intense boling of the feed liquid, low energy utilization, large dead volume, cleaning difficulty, etc. This invention has an extensive applied prospect.