公开(公告)号：WO2016083358A1

公开(公告)日：2016-06-02

申请号：PCT/EP2015/077474

申请日：2015-11-24

Applicant: FREIE UNIVERSITÄT BERLIN

Inventor： SÜSS, Dr. Björn

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/453 ,  G02B26/10

CPC classification number: G01J3/2889 ,  G01J3/021 ,  G01J3/4532 ,  G01J3/4535 ,  G02B26/001

Abstract: The present invention is directed to an Interferometer (100) comprising a source (110) of a primary energy beam (111), a first reflector (120) being provided static such that a first path length from the source (110) to the first reflector (120) is constant, a reflector (1) with an energy beam reflecting surface (20) being provided by an outer surface of a sonotrode (10), wherein the reflector (1) is provided to oscillate such that a second path length from the source (110) to the reflecting surface (20) is variable, a target (140), a means for splitting an energy beam (160) arranged such that it divides the primary beam (111) into a first energy beam (112) incident onto the first reflector (120), and a second energy beam (113) incident onto the reflector (1) adapted to oscillate, and a means for combining energy beams (170) arranged such that it combines a third energy beam (114) reflected from the first reflector (120) and a fourth energy beam (115) reflected from the reflector (1) adapted to oscillate incident onto the target (140). Further provided is an infrared Fourier transform spectrometer (200).

Abstract translation: 本发明涉及一种包括一次能量束（111）的源（110）的干涉仪（100），静态设置的第一反射器（120），使得从源（110）到第一 反射器（120）是恒定的，具有能量束反射表面（20）的反射器（1）由超声波发生器（10）的外表面提供，其中反射器（1）被设置为使得第二路径长度 从源（110）到反射表面（20）是可变的，目标（140），用于分割能量束（160）的装置，其布置成使得其将主光束（111）分成第一能量束（112） ）入射到第一反射器（120）上，以及入射到适于振荡的反射器（1）上的第二能量束（113）和用于组合能量束（170）的装置，其被布置成使得其组合第三能量束 ）和从反射器（1）a反射的第四能量束（115） 使事件振荡到目标（140）上。 进一步提供红外傅里叶变换光谱仪（200）。

公开(公告)号：WO2015015941A1

公开(公告)日：2015-02-05

申请号：PCT/JP2014/066366

申请日：2014-06-13

Applicant: OSAKA UNIVERSITY

Inventor： PAVILLON, Nicolas ,  SMITH, Nicholas Isaac

IPC: G01N21/65 ,  G01B11/24

CPC classification number: G01N21/65 ,  G01J3/0248 ,  G01J3/0289 ,  G01J3/2823 ,  G01J3/2889 ,  G01J3/44 ,  G01J2003/064 ,  G01N2201/10

Abstract: An apparatus comprises a coherent source (103) radiating coherent light to a sample, an excitation source (101) radiating excitation light to the sample, a scanning unit (102) controlling at least the radiated location and/or radiated shape of the excitation light on the sample, a signal separation unit (106) dividing a mixed signal from the sample into a coherent signal and spectroscopic signal, at least one detector (109,112) measuring the spectroscopic signal and coherent signal, at least one processing unit (110, 113) converting the spectroscopic signal into spectroscopic data and converting the coherent signal into a coherent image, and a feedback unit (118) controlling the scanning unit (102) based on the coherent image.

Abstract translation: 一种装置包括对样品辐射相干光的相干光源（103），向样品辐射激发光的激发源（101），至少控制激发光的辐射位置和/或辐射形状的扫描单元 在样本上，将来自样本的混合信号分为相干信号和分光信号的信号分离单元（106），测量分光信号和相干信号的至少一个检测器（109,112），至少一个处理单元（110,113 ）将所述分光信号转换为光谱数据并将所述相干信号转换为相干图像;以及反馈单元（118），其基于所述相干图像来控制所述扫描单元（102）。

公开(公告)号：WO2009018953A2

公开(公告)日：2009-02-12

申请号：PCT/EP2008006286

申请日：2008-07-30

Applicant: ZEISS CARL MEDITEC AG ,  BRODSCHELM ANDREAS ,  MOHR THOMAS ,  BUBLITZ DANIEL

Inventor： BRODSCHELM ANDREAS ,  MOHR THOMAS ,  BUBLITZ DANIEL

IPC: A61B3/12

CPC classification number: A61B3/1225 ,  G01J3/10 ,  G01J3/2803 ,  G01J3/2889 ,  G01J3/4406 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/6417 ,  G01N2021/6421

Abstract: The invention relates to the detection of state conditions pi(x) of an object (1) to be examined comprising the steps of providing a plurality of variables from measurements of the object (1), wherein the variables can be illustrated by means of a predetermined system function as a function of an object response S(pi,?) by the object (1) and of spectral measurement conditions Lr(?) of the measurements, wherein the object response S(pi, ?) contains the state conditions pi as parameters, and the calculation of the state conditions pi(x) from the variables, wherein the calculation of the state conditions pi(x) comprises an adjustment of the parameters of the object response S(pi,?) such that the variables are represented by the system function. The invention further relates to a measurement device (100) for detecting state conditions pi(x) of an object (1) to be examined. A method for measuring the fluorescence of a pigment in the eye (1) comprises the steps of illuminating the eye (1) using excitation light in a predetermined excitation wavelength range (?ex), measuring a first fluorescence signal (S1) in a first emission wavelength range (?em,1), measuring a second fluorescence signal (S2) in a second emission wavelength range (?em,2), and detecting an autofluorescence signal (S) of the pigment from the first and second fluorescence signals (S1, S2). The invention further relates to a measuring device (100) equipped for the measurement of the fluorescence of a pigment in the eye (1) and comprising an illumination device (10) and a detection device (20).

Abstract translation: 一种用于确定状态的条件P法？（X）的被检查对象（1），包括从测量对象物（1），在提供多个测量参数的步骤，其中响应于一个对象响应S中的测定值通过预定系统功能（第 ？，测量的？是）的对象（1）和（光谱测定条件LR？）表示，其中，所述对象响应S（p？，？）包含状态条件PI，作为参数，和p的状态的条件计算？（x）的 所测量的变量，其中所述状态条件PI（x）的物体响应S的参数的适配（PI，？）的计算包括这样一种方式，所测量的值由系统的功能表示。 还描述了一种用于确定状态的条件P A测量装置（100）？对象的（X）要被检查（1）。 一种用于测量颜料的荧光在（1），其包括照射眼睛（1）用激发光在预定激发波长（λ实施例）的步骤的眼睛，测量在第一发射波长范围内的第1荧光信号（S1）（方法？ EM，1）“测量第二荧光信号（S2）（在蛋NEM第二发射波长范围？EM，2）？ 和检测从所述第一和第二荧光信号（S1，S2）中的颜料的自发荧光信号（S）的。 还描述的测量装置（100），用于测量颜料的荧光在眼睛（1）被布置和照明装置（10）和包括检测器装置（20）。

公开(公告)号：WO2006089093A2

公开(公告)日：2006-08-24

申请号：PCT/US2006005595

申请日：2006-02-17

Applicant: UNIV MICHIGAN ,  YE JING YONG ,  NORRIS THEODORE B ,  BAKER JAMES R

Inventor： YE JING YONG ,  NORRIS THEODORE B ,  BAKER JAMES R

IPC: G01J3/30

CPC classification number: G01J3/4406 ,  G01J3/10 ,  G01J3/2889 ,  G01N21/6408 ,  G01N21/6458

Abstract: A fluorescence detection system for testing a sample having at least one fluorophore. The fluorescence detection system comprises a white light generation system outputting a white light pulse. The white light pulse has a first frequency range and a first time duration. The white light pulse excites the at least one fluorophore of the sample to emit a fluorescence. The fluorescence has a second frequency range and a second time duration, wherein the first time duration is less than the second time duration. A time-resolving detector receives the fluorescence and at least a portion of the white light pulse and separates the fluorescence from the portion of the white light pulse.

Abstract translation: 一种用于测试具有至少一个荧光团的样品的荧光检测系统。 荧光检测系统包括输出白光脉冲的白光发生系统。 白光脉冲具有第一频率范围和第一持续时间。 白光脉冲激发样品的至少一个荧光团以发射荧光。 荧光具有第二频率范围和第二持续时间，其中第一持续时间小于第二持续时间。 时间分辨检测器接收荧光和白光脉冲的至少一部分，并将荧光与白光脉冲的该部分分离。

公开(公告)号：WO2006029890A1

公开(公告)日：2006-03-23

申请号：PCT/EP2005/010002

申请日：2005-09-16

Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE INDUSTRIAL RELATIONS OFFICE (SRI) ,  GANIERE, Jean-Daniel

Inventor： GANIERE, Jean-Daniel

IPC: G01J3/04 ,  G01J3/28

CPC classification number: G01J3/2889 ,  G01J3/04 ,  G01J3/22

Abstract: Light dispersing device comprising a slit element having a slit for exposure to electromagnetic radiation, wherein the slit element is configured and disposed for turning the slit between at least two positions. The light dispersing device is used together with a streak camera, whereby in a first position the slit is adjusted to influence the temporal resolution of the streak camera and in a second postion the slit is adjusted to influence the spectral resolution of the streak camera.

Abstract translation: 光分配装置包括具有用于暴露于电磁辐射的狭缝的狭缝元件，其中，所述狭缝元件构造和设置用于在至少两个位置之间转动狭缝。 光分散装置与条纹相机一起使用，由此在第一位置调整狭缝以影响条纹相机的时间分辨率，并且在第二位置中，调节狭缝以影响条纹相机的光谱分辨率。

公开(公告)号：WO2003016843A1

公开(公告)日：2003-02-27

申请号：PCT/GB2002/003811

申请日：2002-08-19

Applicant: PERKINELMER INTERNATIONAL C.V. ,  HOULT, Robert, Alan ,  CARTER, Ralph, Lance

Inventor： HOULT, Robert, Alan ,  CARTER, Ralph, Lance

IPC: G01J3/453

CPC classification number: G01J3/4535 ,  G01J3/06 ,  G01J3/2889 ,  G02B21/26

Abstract: An FT-IR microscope is operated in association with a scanning spectrometer in such a way that incremental movement of the movable stage of the microscope is synchronised with the scanning spectrometer. This minimises delays in processing time.

Abstract translation: FT-IR显微镜与扫描光谱仪相关联地操作，使得显微镜的可移动台的增量移动与扫描光谱仪同步。 这最大限度地减少了处理时间的延迟。

公开(公告)号：WO02017622A1

公开(公告)日：2002-02-28

申请号：PCT/US2001/026562

申请日：2001-08-24

IPC: G01N21/64 ,  G01N15/00 ,  G01N15/02 ,  G01N15/14 ,  G01N21/27 ,  G06K9/00 ,  H04N5/232

CPC classification number: G06K9/00127 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0232 ,  G01J3/14 ,  G01J3/2823 ,  G01J3/2889 ,  G01N15/14 ,  G01N21/6458 ,  G01N2015/1497

Abstract: Light from an object (152) moving through an imaging system (154) is collected, dispersed, and imaged onto a time delay integration (TDI) detector (148) that is inclined relative to an axis of motion of the object, producing a pixilated output signal. In one embodiment, the movement of the image object over the TDI detector (148) is asynchronous with the movement of the output signal producing an output signal that is a composite of the image of the object at varying focal point along the focal plane. In another embodiment, light from the object is periodically incident on the inclined TDI, producing a plurality of spaced apart images and corresponding output signals that propagate across the TDI detector (148). The inclined plane enables images of FISH probes or other components within an object to be produced at different focal point, so that the 3D spatial relationship between the FISH probes or components can be resolved.

Abstract translation: 来自移动通过成像系统（154）的物体（152）的光被收集，分散和成像到相对于物体的运动轴线倾斜的时间延迟积分（TDI）检测器（148），产生像素化的 输出信号。 在一个实施例中，图像对象在TDI检测器（148）上的移动与产生输出信号的输出信号的移动是异步的，该输出信号是沿着焦平面的变化焦点处的物体的图像的复合。 在另一个实施例中，来自物体的光周期性地入射到倾斜TDI上，产生多个间隔开的图像和跨越TDI检测器（148）传播的对应的输出信号。 倾斜平面使得可以在不同焦点处产生物体内的FISH探针或其他部件的图像，从而可以解决FISH探针或部件之间的3D空间关系。

公开(公告)号：WO01006209A1

公开(公告)日：2001-01-25

申请号：PCT/US2000/019325

申请日：2000-07-17

IPC: G01J3/45 ,  G01J3/28 ,  G01J3/453 ,  G01N21/35 ,  G01B9/02

CPC classification number: G01J3/453 ,  B01J2219/00587 ,  B01J2219/00707 ,  G01J3/2889

Abstract: A FTIR (100) spectrometer is used to illuminate the sample library in either step scan or rapid scan mode and IR light(s) emitted by the combination library is recorded by a focal plane array. The Fourier transform of the measured data is then taken.

Abstract translation: 使用FTIR（100）光谱仪以步进扫描或快速扫描模式照亮样品库，由组合库发射的IR光由焦平面阵列记录。 然后对测量数据进行傅里叶变换。

公开(公告)号：WO00062024A1

公开(公告)日：2000-10-19

申请号：PCT/US2000/003764

申请日：2000-02-14

IPC: G01J3/02 ,  G01J3/06 ,  G01J3/10 ,  G01J3/18 ,  G01J3/28 ,  G01J3/32 ,  G01J3/457 ,  G01N21/39 ,  G02B26/08 ,  G02B27/10

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/027 ,  G01J3/06 ,  G01J3/10 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/2889 ,  G01J3/32 ,  G01J3/457 ,  G01J2003/2866 ,  G01N21/39 ,  G01N2021/393 ,  G01N2021/6463 ,  G02B26/0841 ,  G02B27/1086

Abstract: A spectrometer (10) includes a two-dimensional array of modulatable microm-irrors (18), a detector (20), and an analyzer (22). The micro-mirrors are positioned for receiving individual radiation components forming a part of a radiation source. The micro-mirrors are modulated at different modulation rates in order to reflect individual radiation components at known and different modulation rates. The micro-mirrors combine a number of the reflected individual radiation components and reflect them to the detector. The detector receives the combined radiation components and creates an output signal. The analyzer is coupled to the detector to receive the output signal and to analyze at least some of the individual radiation components making up the combined reflection. By using a micro-mirror array that modulates the radiation components at different rates, all of the radiations components can be focused onto a single detector to maximize the signal-to-noise ratio of the detector.

Abstract translation: 光谱仪（10）包括可调制的微反应器（18），检测器（20）和分析器（22）的二维阵列。 微镜被定位成用于接收形成辐射源的一部分的各个辐射分量。 以不同的调制速率调制微镜，以便以已知和不同的调制速率反射各个辐射分量。 微反射镜组合了多个反射的单个辐射分量并将其反射到检测器。 检测器接收组合的辐射分量并产生输出信号。 分析器耦合到检测器以接收输出信号并分析构成组合反射的各个辐射分量中的至少一些。 通过使用以不同速率调制辐射分量的微镜阵列，所有辐射分量可以聚焦到单个检测器上，以使检测器的信噪比最大化。

公开(公告)号：WO1998002734A1

公开(公告)日：1998-01-22

申请号：PCT/US1997012202

申请日：1997-07-15

Applicant: MIRAGE TECHNOLOGIES

Inventor： MIRAGE TECHNOLOGIES ,  BRENAN, Colin, J., H. ,  HUNTER, Ian

IPC: G01N21/85

CPC classification number: G01J3/2889 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/31 ,  G01N21/65 ,  G01N21/85 ,  G01N21/8507

Abstract: A system for providing real-time control of a process that is monitored at a plurality of process locations by spectrometric techniques. The system utilizes an imaging spectrometer having an optical image input and a spectral image output. A plurality of modules are employed; one module is disposed in each process location. Each module has an illumination source for illuminating such location; a collector for collecting light that has been scattered at such location and directing such light to a collector output; and an optical fiber arranged to provide optical communication from the collector output to a pixel location of the optical image of the imaging spectrometer. In addition an optical transducer is placed in communication with the spectral image output of the imaging spectrometer. The optical transducer provides as an output, spectral data, associated with each pixel location of the optical image input and therefore associated with each process location, for the purpose of process control.

Abstract translation: 一种用于通过光谱技术在多个处理位置处监视的过程提供实时控制的系统。 该系统利用具有光学图像输入和光谱图像输出的成像光谱仪。 采用多个模块; 一个模块设置在每个处理位置。 每个模块都有一个用于照亮这样位置的照明源; 收集器，用于收集已经在该位置处散射并将这种光引导到集电极输出的光; 以及布置成提供从集电极输出到成像光谱仪的光学图像的像素位置的光学通信的光纤。 此外，光学换能器放置成与成像光谱仪的光谱图像输出通信。 为了过程控制的目的，光学换能器提供与光学图像输入的每个像素位置相关联并因此与每个处理位置相关联的输出光谱数据。