公开(公告)号：WO2015095678A3

公开(公告)日：2015-09-17

申请号：PCT/US2014071448

申请日：2014-12-19

Applicant: MEVION MEDICAL SYSTEMS INC

Inventor： ZWART GERRIT TOWNSEND ,  JONES MARK R

IPC: A61N5/10 ,  G21K1/04 ,  G21K5/04 ,  H05H13/02

CPC classification number: A61N5/1043 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1077 ,  A61N5/1083 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/046 ,  G21K1/10 ,  H05H13/02 ,  H05H2007/004 ,  H05H2007/007 ,  H05H2007/122

Abstract: A particle therapy system includes a particle accelerator to output a particle beam; and a scanning system for the particle accelerator to scan the particle beam across at least part of an irradiation target. The scanning system is configured to scan the particle beam in two dimensions that are at an angle relative to a direction of the particle beam. A structure defines an edge. The structure is controllable to move in the two dimensions relative to the irradiation target such that at least part of the structure is between at least part of the particle beam and the irradiation target. The structure includes a material that inhibits transmission of the particle beam.

Abstract translation: 粒子治疗系统包括粒子加速器以输出粒子束; 以及扫描系统，用于粒子加速器扫描穿过至少部分照射目标的粒子束。 扫描系统被配置成以相对于粒子束的方向成角度的二维扫描粒子束。 结构定义了一个边。 该结构可控制成相对于照射目标在二维中移动，使得该结构的至少一部分位于至少部分的粒子束与照射目标之间。 该结构包括阻止粒子束透射的材料。

公开(公告)号：WO2014052709A2

公开(公告)日：2014-04-03

申请号：PCT/US2013062103

申请日：2013-09-27

Applicant: MEVION MEDICAL SYSTEMS INC

Inventor： GALL KENNETH P ,  ZWART GERRIT TOWNSEND ,  VAN DER LAAN JAN ,  MOLZAHN ADAM C ,  O'NEAL III CHARLES D ,  SOBCZYNSKI THOMAS C ,  COOLEY JAMES

IPC: H05H7/12

CPC classification number: H05H7/02 ,  A61N5/1077 ,  A61N2005/1087 ,  H05H7/12 ,  H05H13/02 ,  H05H2007/082 ,  H05H2007/122

Abstract: In an example, a synchrocyclotron includes a particle source to provide pulses of ionized plasma to a cavity; a voltage source to provide a radio frequency (RF) voltage to the cavity to accelerate particles from the plasma column outwardly; and an extraction channel to receive a beam of particles from the cavity for output from the particle accelerator. The particle source is configured to control pulse widths of the ionized plasma in order to control an intensity of the beam of particles. This example synchrocyclotron may include one or more of the following features, either alone or in combination.

Abstract translation: 在一个示例中，同步回旋加速器包括用于向空腔提供离子化等离子体的脉冲的粒子源; 电压源，向腔提供射频（RF）电压以向外加速来自等离子体柱的粒子; 以及提取通道，以接收来自空腔的粒子束以从粒子加速器输出。 粒子源被配置为控制离子化等离子体的脉冲宽度以控制粒子束的强度。 该示例同步回旋加速器可以单独或组合地包括以下特征中的一个或多个。

公开(公告)号：WO2015095678A2

公开(公告)日：2015-06-25

申请号：PCT/US2014/071448

申请日：2014-12-19

Applicant: MEVION MEDICAL SYSTEMS, INC.

Inventor： ZWART, Gerrit Townsend ,  JONES, Mark R.

IPC: A61N5/10

CPC classification number: A61N5/1043 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1077 ,  A61N5/1081 ,  A61N5/1083 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/046 ,  G21K1/10 ,  H05H13/02 ,  H05H2007/004 ,  H05H2007/007 ,  H05H2007/122

Abstract: A particle therapy system includes a particle accelerator to output a particle beam; and a scanning system for the particle accelerator to scan the particle beam across at least part of an irradiation target. The scanning system is configured to scan the particle beam in two dimensions that are at an angle relative to a direction of the particle beam. A structure defines an edge. The structure is controllable to move in the two dimensions relative to the irradiation target such that at least part of the structure is between at least part of the particle beam and the irradiation target. The structure includes a material that inhibits transmission of the particle beam.

Abstract translation: 颗粒治疗系统包括输出粒子束的粒子加速器; 以及用于粒子加速器的扫描系统扫描穿过至少部分照射目标的粒子束。 扫描系统被配置为以与粒子束的方向成一角度的二维扫描粒子束。 一个结构定义一个边。 该结构是可控制的，以相对于照射目标在两维中移动，使得结构的至少一部分在至少部分的粒子束和照射目标之间。 该结构包括抑制粒子束透射的材料。

公开(公告)号：WO2012031299A3

公开(公告)日：2012-08-16

申请号：PCT/US2011050561

申请日：2011-09-06

Applicant: VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH ,  STEPHANI THOMAS ,  BEHRENS UWE ,  ROECKEN HEINRICH ,  BAUMGARTEN CHRISTIAN ,  TIMMER JAN ,  HAO JAMES P

Inventor： STEPHANI THOMAS ,  BEHRENS UWE ,  ROECKEN HEINRICH ,  BAUMGARTEN CHRISTIAN ,  TIMMER JAN

IPC: A61N5/10 ,  H05H13/00

CPC classification number: H05H7/02 ,  A61N5/10 ,  A61N5/1077 ,  A61N2005/1087 ,  H01J3/14 ,  H05H13/005 ,  H05H2007/122 ,  H05H2277/11

Abstract: Systems and methods are provided to perform efficient, automatic adjustment of cyclotron beam currents within a wide range for multiple treatment layers within the same patient and treatment session; and to perform efficient, automatic cyclotron initialization, and calibration. In an embodiment, efficient adjustment is achieved by using beam current attenuation by an electrostatic vertical deflector installed in the inner center of the cyclotron. The beam current may, for example, be adjusted by the high voltage applied to the electrostatic vertical deflector, in front of each treatment the attenuation curve of the vertical deflector is recorded. Based on this attenuation curve, the vertical deflector voltage for the needed beam current of each irradiation layer is interpolated. In another embodiment, a process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron.

Abstract translation: 提供系统和方法以在相同的患者和治疗期内对多个治疗层在宽范围内执行高效的自动调节回旋束电流; 并执行高效的自动回旋加速器初始化和校准。 在一个实施例中，通过使用安装在回旋加速器内部中心的静电垂直偏转器的束电流衰减来实现有效调节。 束流例如可以通过施加到静电垂直偏转器的高电压来调节，在每次处理之前记录垂直偏转器的衰减曲线。 基于该衰减曲线，内插每个照射层所需射束电流的垂直偏转器电压。 在另一个实施例中，提供了一种过程，该过程允许在隔夜或维护强制关机后自动化回旋加速器的初始化。 在一个实施例中，定义了五个独立的回旋加速器系统状态，并且一个状态到另一个状态之间的转换可以例如通过回旋加速器的控制系统自动化。

公开(公告)号：WO2012031299A2

公开(公告)日：2012-03-08

申请号：PCT/US2011/050561

申请日：2011-09-06

Applicant: VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH ,  STEPHANI, Thomas ,  BEHRENS, Uwe ,  ROECKEN, Heinrich ,  BAUMGARTEN, Christian ,  TIMMER, Jan ,  HAO, James, P.

Inventor： STEPHANI, Thomas ,  BEHRENS, Uwe ,  ROECKEN, Heinrich ,  BAUMGARTEN, Christian ,  TIMMER, Jan

IPC: A61N5/10 ,  H05H13/00

CPC classification number: H05H7/02 ,  A61N5/10 ,  A61N5/1077 ,  A61N2005/1087 ,  H01J3/14 ,  H05H13/005 ,  H05H2007/122 ,  H05H2277/11

Abstract: Systems and methods are provided to perform efficient, automatic adjustment of cyclotron beam currents within a wide range for multiple treatment layers within the same patient and treatment session; and to perform efficient, automatic cyclotron initialization, and calibration. In an embodiment, efficient adjustment is achieved by using beam current attenuation by an electrostatic vertical deflector installed in the inner center of the cyclotron. The beam current may, for example, be adjusted by the high voltage applied to the electrostatic vertical deflector, in front of each treatment the attenuation curve of the vertical deflector is recorded. Based on this attenuation curve, the vertical deflector voltage for the needed beam current of each irradiation layer is interpolated. In another embodiment, a process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron.

Abstract translation: 提供系统和方法以在相同的患者和治疗期间内的多个治疗层的范围内对回旋加速器束电流进行有效的自动调节; 并执行有效的自动回旋加速器初始化和校准。 在一个实施例中，通过使用安装在回旋加速器的内部中心的静电垂直偏转器来使用束流衰减来实现有效的调节。 例如，通过施加到静电垂直偏转器的高电压来调节束电流，在每个处理前面记录垂直偏转器的衰减曲线。 基于该衰减曲线，对每个照射层所需的束电流的垂直偏转器电压进行插值。 在另一个实施例中，提供了一种过程，其允许在过夜或维护强制停机之后对回旋加速器的初始化进行自动化。 在一个实施例中，定义了五个独立的回旋加速器系统状态，并且一个状态与另一个状态之间的转换可以例如由回旋加速器的控制系统自动化。

公开(公告)号：WO2019043070A2

公开(公告)日：2019-03-07

申请号：PCT/EP2018/073259

申请日：2018-08-29

Applicant: ALCELI LIMITED

Inventor： HUNT, Steven

CPC classification number: H05H9/041 ,  H05H7/18 ,  H05H7/22 ,  H05H2007/122

Abstract: A linear particle accelerating structure is provided for accelerating protons using radio frequency, RF, radiation, the structure comprising at least two coupled resonant cavity units. Each resonant cavity unit comprising a corresponding resonant cavity with an input port and an output port for a beam of protons; and an RF input to receive an RF signal; an RF phase shifter to control the phase of the RF signal. The particle accelerating structure further comprises at least one RF phase shifter to adjust, in one or more of the respective cavities, a phase of the RF signal to expose the protons to an accelerating portion of the electric field for a first duration and to expose the protons to a decelerating portion of the electric field for a second duration, wherein the first duration is greater than the second duration and greater than zero and wherein the second duration is greater than or equal to zero.

公开(公告)号：WO2017123281A1

公开(公告)日：2017-07-20

申请号：PCT/US2016/047326

申请日：2016-08-17

Applicant: GENERAL ELECTRIC COMPANY

Inventor： PÄRNASTE, Martin ,  BÄCKLUND, Andreas ,  WALENIUS, Lars

IPC: H05H13/00 ,  H05H7/02 ,  H05H7/18

CPC classification number: H05H7/10 ,  H05H7/12 ,  H05H13/005 ,  H05H2007/025 ,  H05H2007/122

Abstract: Radio-frequency (RF) electrode for a cyclotron. The RF electrode includes a hollowed dee having first and second surfaces that oppose each other and define a gap therebetween. The hollowed dee is configured to be electrically controlled to direct a beam of charged particles through the gap and along an orbit plane of the cyclotron. The orbit plane extends parallel to the first and second surfaces through the gap. The RF electrode also includes a bridge structure that is coupled to and extends away from the hollowed dee. The bridge structure includes a side wall that defines an interior cavity of the bridge structure. The side wall has a particle opening therethrough that coincides with or is proximate to the orbit plane such that the particle opening receives neutral particles from an orbit of the charged particles.

Abstract translation: 用于回旋加速器的射频（RF）电极。 RF电极包括具有彼此相对的第一和第二表面并在其之间限定间隙的中空的凹部。 中空的电极被配置为被电控制以引导带电粒子束通过间隙并沿着回旋加速器的轨道平面。 轨道平面通过间隙平行于第一和第二表面延伸。 RF电极还包括桥接结构，该桥接结构连接到中空的凹部并远离凹部延伸。 桥结构包括限定桥结构的内腔的侧壁。 侧壁具有穿过其的粒子开口，其与轨道平面重合或接近轨道平面，使得粒子开口从带电粒子的轨道接收中性粒子。

公开(公告)号：WO2015107128A1

公开(公告)日：2015-07-23

申请号：PCT/EP2015/050719

申请日：2015-01-15

Applicant: THE QUEEN'S UNIVERSITY OF BELFAST

Inventor： KAR, Satyabrata

IPC: H05H7/04 ,  H05H15/00

CPC classification number: H01J29/58 ,  H01J27/022 ,  H01J27/24 ,  H01J29/803 ,  H01J29/84 ,  H05H7/04 ,  H05H7/08 ,  H05H7/12 ,  H05H15/00 ,  H05H2007/043 ,  H05H2007/046 ,  H05H2007/082 ,  H05H2007/122

Abstract: A system for focusing and accelerating a beam of electrically charged particles, for example protons. The system comprises: a beam generator; a charge pulse generator;and a focusing and accelerating device comprising a body with a core. The body defines a charge path extending along the body and beam generator directs a beam of electrically charged particles through the core. The charge pulse generator simultaneously delivers charge pulses to the charge path. The charge path may be helical in shape. Movement of the charge pulse along the path creates an electric field that simultaneously accelerates and focuses the beam.

Abstract translation: 用于聚焦和加速带电粒子束的系统，例如质子。 该系统包括：光束发生器; 充电脉冲发生器;以及包括具有芯体的聚焦加速装置。 主体限定沿主体延伸的电荷路径，并且光束发生器引导带电粒子束通过芯。 充电脉冲发生器同时向充电路径传送电荷脉冲。 充电路径可以是螺旋形的。 沿着路径的充电脉冲的移动产生同时加速并聚焦光束的电场。

公开(公告)号：WO2012175381A1

公开(公告)日：2012-12-27

申请号：PCT/EP2012/061178

申请日：2012-06-13

Applicant: SIEMENS AKTIENGESELLSCHAFT ,  HEID, Oliver

Inventor： HEID, Oliver

IPC: H05H7/18 ,  H05H7/22

CPC classification number: H05H7/18 ,  H05H7/22 ,  H05H2007/122 ,  H05H2007/227

Abstract: Die Erfindung betrifft einen Teilchenbeschleuniger (100) zum Beschleunigen eines helixförmigen Strahls (150) geladener Teilchen (151), die sich jeweils mit einer vorgegebenen Geschwindigkeit (v 1 ) gradlinig entlang einer vorgegebenen Achse (101) bewegen, umfassend: - eine kreiszylinderförmige HF-Kavität (110) mit einem ringförmigen Eintrittsspalt (113) und einem dem Eintrittsspalt (113) gegenüber liegenden ringförmigen Austrittsspalt (115) für den helixförmigen Teilchenstrahl (150), und - eine HF-Generatoreinrichtung (120) zum Erzeugen einer zirkular polarisierten elektromagnetischen Welle (160) innerhalb der HF-Kavität (110), wobei die zirkulär polarisierte elektromagnetische Welle ein in Richtung der Achse (101) orientiertes und synchron mit der Eintrittsstelle des helixförmigen Teilchenstrahls (150) in die HF-Kavität (110) um die Achse (101) rotierendes elektrisches Feld (161) umfasst. Ferner betrifft die Erfindung eine Beschleunigeranordnung sowie ein Verfahren zum Beschleunigen eines helixförmigen Strahls (150) geladener Teilchen (151).

Abstract translation: 本发明涉及用于带电粒子加速（151），其中的每一个移动在沿规定轴（101）的直线的预定速度（V1），其包括螺旋束（150）的粒子加速器（100）： - 圆柱形RF空腔 （110）具有环形入口间隙（113）和入口狭缝（113）的环形出口缝隙（115），用于螺旋粒子束（150）相对，以及 - 用于生成圆偏振电磁波的RF发生器装置（120）（160 ）（RF空腔110）内，所述圆偏振电磁波定向（在轴线101的方向上）和同步（与入口点的螺旋粒子束150）到RF空腔（110）围绕所述轴线（101） 旋转电场（161）包括。 此外，本发明提供了一种加速器装置和用于加速的方法涉及的带电粒子（151）的螺旋束（150）。