公开(公告)号：WO2010088258A3

公开(公告)日：2010-10-14

申请号：PCT/US2010022208

申请日：2010-01-27

Applicant: TRANSCEND MEDICAL INC ,  SILVESTRINI THOMAS A ,  DE JUAN EUGENE JR

Inventor： SILVESTRINI THOMAS A ,  DE JUAN EUGENE JR

IPC: A61F9/007

CPC classification number: A61F9/00781 ,  A61F2210/0019

Abstract: Described herein are devices and methods for treating eye conditions. Described is an ocular implant (105) including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber (ac), at least one outflow port communicates with the suprachoroidal space (schs) to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.

Abstract translation: 本文描述了用于治疗眼睛状况的装置和方法。 描述了一种眼部植入物（105），其包括细长构件，其具有形成流动路径的内腔，至少一个与流动通道连通的流入口以及与流动通路连通的至少一个流出口。 细长构件适于定位在眼睛中，使得至少一个流入口与前房（ac）连通，至少一个流出口与脉管外空间（schs）连通，以在前房和前房之间提供流体通路 当细长构件植入眼睛时的脉络膜间隙。 细长构件具有赋予细长构件刚性的壁材料。 选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。

公开(公告)号：WO2009158524A3

公开(公告)日：2010-03-11

申请号：PCT/US2009048703

申请日：2009-06-25

Applicant: TRANSCEND MEDICAL INC ,  SILVESTRINI THOMAS A ,  JOHN STEVEN ,  GARCIA JOSE ,  LILLY RICHARD S

Inventor： SILVESTRINI THOMAS A ,  JOHN STEVEN ,  GARCIA JOSE ,  LILLY RICHARD S

IPC: A61F9/007

CPC classification number: A61F9/00781

Abstract: Disclosed are devices, methods and systems for treatment of eye disease such as glaucoma. Implants (105) are described herein that enhance aqueous flow through the normal outflow system of the eye with minimal to no complications. The implant can be reversibly deformed to a first shape, such as a generally linear shape conducive to insertion. Upon insertion, the implant can deform to a second shape, such as a generally non-linear shape conducive to retention within the eye. The shape also improves fluid flow from the anterior chamber and prevents or reduces clogging.

Abstract translation: 公开了用于治疗诸如青光眼的眼睛疾病的装置，方法和系统。 本文描述了植入物（105），其以最少到没有并发症来增强通过眼睛的正常流出系统的水流。 植入物可以可逆地变形为第一形状，例如有利于插入的大致线性形状。 在插入时，植入物可以变形为具有有利于保留在眼睛内的大体非线性形状的第二形状。 该形状还改善了来自前房的流体流动并防止或减少了堵塞。

公开(公告)号：WO2006060380A3

公开(公告)日：2006-12-07

申请号：PCT/US2005043108

申请日：2005-11-30

Applicant: ACUFOCUS INC ,  SILVESTRINI THOMAS A

Inventor： SILVESTRINI THOMAS A

IPC: A61F2/14

CPC classification number: C23C14/0005 ,  A61F2/0059 ,  A61F2/14 ,  A61F2/15 ,  A61F2240/001 ,  A61F2250/0014 ,  C23C16/01

Abstract: A method is provided for making a mask (6200) configured to improve the depth of focus of an eye of a patient. A substrate (6000) is provided with a mask forming feature (6008). The mask forming feature comprises an annular surface (6020) that has a curved profile (6016) that corresponds to the curvature of a corneal layer of the eye. A release layer (6080) is formed on the annular surface. A mask layer (6100) of a biocompatible metal is formed above the release layer. The mask layer is separated from the substrate.

Abstract translation: 提供了一种用于制造掩模（6200）的方法，其被配置为改善患者眼睛的焦点深度。 衬底（6000）设置有掩模形成特征（6008）。 掩模形成特征包括具有对应于眼睛的角膜层的曲率的弯曲轮廓（6016）的环形表面（6020）。 释放层（6080）形成在环形表面上。 生物相容性金属的掩模层（6100）形成在剥离层的上方。 掩模层与基板分离。

公开(公告)号：WO2006113377A2

公开(公告)日：2006-10-26

申请号：PCT/US2006013944

申请日：2006-04-13

Applicant: ACUFOCUS INC ,  SILVESTRINI THOMAS A

Inventor： SILVESTRINI THOMAS A

IPC: A61L27/16 ,  A61F9/007

CPC classification number: A61F2/145 ,  A61F2/14 ,  A61F2/15 ,  A61F9/0008 ,  A61F9/00834 ,  A61L27/16 ,  A61L2430/16 ,  G02C7/02 ,  G02C7/04 ,  G02C7/165 ,  C08L27/16

Abstract: Disclosed are masks configured to be implanted in a cornea of a patient. In one embodiment, the body of the mask has a light transmitting portion, a light blocking portion disposed about the light transmitting portion, and an outer periphery surrounding the light blocking portion. The mask is adapted to reside between two intracorneal layers of a cornea. In a preferred embodiment, the mask is formed from a material comprising a highly fluorinated polymeric material and an opacification agent and is resistant to degradation upon exposure to ultraviolet light. In another embodiment, the mask is formed from a material which comprises a polyanionic compound. In some embodiments, the mask includes one or more wound healing modulator compounds to aid in proper healing following implantation.

Abstract translation: 公开了被配置为植入患者角膜的掩模。 在一个实施例中，掩模的主体具有光透射部分，围绕透光部分设置的遮光部分和围绕遮光部分的外周。 该面罩适于居住在角膜的两个角内层之间。 在优选的实施方案中，掩模由包含高度氟化的聚合物材料和不透明剂的材料形成，并且在暴露于紫外线时具有抗降解性。 在另一个实施方案中，掩模由包含聚阴离子化合物的材料形成。 在一些实施方案中，掩模包括一种或多种伤口愈合调节剂化合物，以在植入后辅助适当的愈合。

公开(公告)号：WO2004105588A3

公开(公告)日：2005-06-09

申请号：PCT/US2004016914

申请日：2004-05-28

Applicant: ACUFOCUS ,  CHRISTIE BRUCE ARTHUR ,  SILVESTRINI THOMAS A ,  HAHNEN KEVIN F ,  KNOPP CARL F

Inventor： CHRISTIE BRUCE ARTHUR ,  SILVESTRINI THOMAS A ,  HAHNEN KEVIN F ,  KNOPP CARL F

IPC: A61B20060101 ,  A61B3/15 ,  A61F2/14 ,  A61F2/16 ,  A61F9/00 ,  G02C7/04

CPC classification number: A61F2/15 ,  A61B3/152 ,  A61F2/14 ,  A61F2/147 ,  A61F9/007 ,  A61F2002/1699 ,  A61F2250/0023 ,  A61F2250/0067 ,  A61F2250/0098 ,  G02C7/04 ,  G02C7/165

Abstract: A mask (4200) configured to be implanted in a cornea of a patient to increase the depth of focus of the patient includes an anterior surface, a posterior surface, and a plurality of holes(4220). The anterior surface is configured to reside adjacent a first corneal layer. The posterior surface is configured to reside adjacent a second corneal layer. The plurality of holes extends at least partially between the anterior surface and the posterior surface. The holes of the plurality of holes are configured to substantially eliminate visible diffraction patterns.

Abstract translation: 构造成植入患者的角膜以增加患者的焦点深度的面罩（4200）包括前表面，后表面和多个孔（4220）。 前表面被配置为邻近第一角膜层。 后表面配置成邻近第二角膜层。 多个孔至少部分地在前表面和后表面之间延伸。 多个孔的孔构造成基本上消除可见的衍射图。

公开(公告)号：WO1995003747A1

公开(公告)日：1995-02-09

申请号：PCT/US1994008458

申请日：1994-07-28

Applicant: KERAVISION, INC. ,  SILVESTRINI, Thomas, A.

Inventor： KERAVISION, INC.

IPC: A61B19/00

CPC classification number: A61F2/147 ,  A61F9/0017 ,  A61F2250/0067 ,  A61L27/14 ,  A61L27/34 ,  A61L2430/16 ,  A61L27/54 ,  A61F2/14

Abstract: This invention is a pliable intrastromal corneal insert (10) designed to be inserted into an inter-lamellar channel made within the cornea of a mammalian eye. It is made of a physiologically compatible polymer and may be used to adjust corneal curvature and thereby correct vision abnormalities. The insert (10) or segment may also be used to deliver therapeutic or diagnostic agents to the corneal interior or to the interior of the eye. The insert (10) subtends at least a portion of a ring, or "arc", encircling the anterior cornea (33) outside of the cornea's field of view but within the cornea's frontal diameter. The invention also includes both a minimally invasive procedure for inserting one or more of the devices into the cornea (12) as well as the thus corrected eye.

Abstract translation: 本发明是一种柔韧的椎间盘内角膜插入物（10），其被设计成插入到在哺乳动物眼睛的角膜内形成的层间通道。 它由生理相容的聚合物制成，可用于调节角膜曲率，从而矫正视力异常。 插入物（10）或片段也可以用于将治疗剂或诊断剂递送到角膜内部或眼睛的内部。 插入件（10）对着至少一部分围绕前角膜（33）的环或“弧形”，其在角膜的视野外，但在角膜的正面直径内。 本发明还包括用于将一个或多个装置插入角膜（12）以及由此校正的眼睛的微创程序。

公开(公告)号：WO2012167167A3

公开(公告)日：2013-02-21

申请号：PCT/US2012040570

申请日：2012-06-01

Applicant: SILVESTRINI THOMAS A

Inventor： SILVESTRINI THOMAS A

IPC: A61F2/14

CPC classification number: A61F9/00781 ,  A61F2250/0024

Abstract: Disclosed are devices and methods for treatment of eye disease such as glaucoma. An implant is placed in the eye wherein the implant provides a fluid pathway for the flow or drainage of aqueous humor from the anterior chamber to the supraciliary or the suprachoroidal space, or to any space in the eye where drainage to that location will lower the intraocular pressure. The implant may include an elongate compressible structure and may be implanted in the eye using a delivery system that folds and or compresses the implant to provide a smaller cross-sectional area to allow a more minimally-invasive procedure. The compressibility of the implant is provided by a porous structure that may be collapsed by compression and delivered through a tube-shaped introducer.

Abstract translation: 公开了用于治疗诸如青光眼之类的眼部疾病的装置和方法。 植入物放置在眼睛中，其中植入物提供流体通道，用于从前房到上腔或脉管外空间或眼睛的任何空间的流动或排出房水，其中到该位置的排泄物将降低眼内 压力。 植入物可以包括细长的可压缩结构，并且可以使用折叠和/或压缩植入物以提供更小的横截面面积以允许更微创入的手术的递送系统将植入眼睛。 植入物的压缩性由多孔结构提供，多孔结构可以通过压缩而折叠并通过管状导引器输送。

公开(公告)号：WO2012167167A2

公开(公告)日：2012-12-06

申请号：PCT/US2012/040570

申请日：2012-06-01

Applicant: SILVESTRINI, Thomas A.

Inventor： SILVESTRINI, Thomas A.

CPC classification number: A61F9/00781 ,  A61F2250/0024

Abstract: Disclosed are devices and methods for treatment of eye disease such as glaucoma. An implant is placed in the eye wherein the implant provides a fluid pathway for the flow or drainage of aqueous humor from the anterior chamber to the supraciliary or the suprachoroidal space, or to any space in the eye where drainage to that location will lower the intraocular pressure. The implant may include an elongate compressible structure and may be implanted in the eye using a delivery system that folds and or compresses the implant to provide a smaller cross-sectional area to allow a more minimally-invasive procedure. The compressibility of the implant is provided by a porous structure that may be collapsed by compression and delivered through a tube-shaped introducer.

Abstract translation: 公开了用于治疗诸如青光眼之类的眼部疾病的装置和方法。 植入物放置在眼睛中，其中植入物提供流体通道，用于从前房到上腔或脉管外空间或眼睛的任何空间的流动或排出房水，其中到该位置的排泄物将降低眼内 压力。 植入物可以包括细长的可压缩结构，并且可以使用折叠和/或压缩植入物以提供更小的横截面面积以允许更微创入的手术的递送系统将植入眼睛。 植入物的压缩性由多孔结构提供，多孔结构可以通过压缩而折叠并通过管状导引器输送。

公开(公告)号：WO2009158517A3

公开(公告)日：2010-03-25

申请号：PCT/US2009048691

申请日：2009-06-25

Applicant: TRANSCEND MEDICAL INC ,  SILVESTRINI THOMAS A ,  JOHN STEVEN ,  GARCIA JOSE ,  LILLY RICHARD S

Inventor： SILVESTRINI THOMAS A ,  JOHN STEVEN ,  GARCIA JOSE ,  LILLY RICHARD S

IPC: A61B3/00 ,  A61F9/007 ,  A61F9/009

CPC classification number: A61B3/117 ,  A61F9/00781

Abstract: Described herein is a hand-held gonioscopic imaging system that can be used to continuously display, capture and record images of the iridocorneal angle within the eye during implantation procedures. The system can be used, for example, during device implantation procedures for the treatment of glaucoma such that landmark identification continues during implantation. Intuitive real-time images viewed through the imaging systems described herein appear to the user to move in the same horizontal orientation as the instrument is actually being moved. The systems described herein also provide independent illumination sources for the camera and the surgical microscope that also have independent illumination controls.

Abstract translation: 这里描述的是一种手持式前庭成像系统，其可以用于在植入过程期间连续地显示，捕获和记录眼睛内的虹膜角膜角度的图像。 该系统可用于例如在用于治疗青光眼的装置植入过程期间，使得在植入期间继续进行标记识别。 通过本文描述的成像系统查看的直观的实时图像对用户来说显示为与仪器实际移动时相同的水平方向移动。 本文所述的系统还为摄像机和手术显微镜提供独立的照明源，其也具有独立的照明控制。

公开(公告)号：WO0025704A9

公开(公告)日：2000-11-09

申请号：PCT/US9926087

申请日：1999-11-04

Applicant: KERAVISION INC ,  SILVESTRINI THOMAS A

Inventor： SILVESTRINI THOMAS A

IPC: A61F2/14

CPC classification number: A61F2/147 ,  A61F2/15

Abstract: An intracorneal implant has a geometry bounded by a ring-shaped section of a cone, approximating a section of a sphere. The intracorneal implant has at least one region of modified elasticity. Typically, the intracorneal implant will have two or more regions of modified elasticity circumferentially spaced around the implant. The regions of modified elasticity affect the cone angle of the implant within each region and hence the corrective power of each region on the cornea. The intracorneal ring implant can be used for correction of various refractive defects of the vision, in particular, astigmatism or astigmatism combined with myopia or hyperopia. The implant may be formed as a ring, split ring, gapped ring or one or more segments of a ring.

Abstract translation: 脊髓内植入物具有由锥体的环形截面限定的几何形状，近似于球体的一部分。 脊髓内植入物具有至少一个具有改良弹性的区域。 通常，椎间植入物将具有围绕植入物周向隔开的两个或更多个改性弹性区域。 修改弹性的区域影响植入物在每个区域内的锥角，从而影响角膜上每个区域的矫正力。 角内环植入物可用于矫正视力的各种折射缺陷，特别是与近视或远视相结合的散光或散光。 植入物可以形成为环，裂环，间隙环或环的一个或多个段。