公开(公告)号：WO2023048596A1

公开(公告)日：2023-03-30

申请号：PCT/RU2022/050101

申请日：2022-03-28

Applicant: ЛАСКАВЫЙ, Владислав Николаевич

Inventor： ЛАСКАВЫЙ, Владислав Николаевич LASKAVYI, Vladislav Nikolaevich

IPC: A61K35/66 ,  A61K47/08 ,  A61P3/08 ,  A61P3/00

Abstract: Изобретения относится к биотехнологии, медицине и ветеринарии. Проблемой является создание комплексной системы поддержания и стабилизации нормального состояния гомеостаза организма человека и животных. Позволяет повысить эффективности профилактических мероприятий при защите от возможного заражения в очагах инфекций. Композиция содержит водорастворимую белковую фракцию с молекулярной массой 6-90 кДа, выделенную из продуктов разрушения возбудителя заболевания в количестве 0,4-0,6% и солевой буферный раствор или дистиллированную воду или физиологический раствор - остальное. Препарат содержит, мас.%: водорастворимая белковая фракция с молекулярной массой 6-90 кДа, выделенная из продуктов разрушения возбудителя заболевания в количестве 0,2-0,3%, растворитель - 49,7-49,8 %, солевой раствор муравьиного альдегида 0,00018-0,06% концентрации – остальное.

公开(公告)号：WO2022254230A1

公开(公告)日：2022-12-08

申请号：PCT/HU2022/050050

申请日：2022-06-04

Applicant: INSTITUTE OF EXPERIMENTAL MEDICINE ,  ZYMBIOSYS RESEARCH AND ÉS DEVELOPMENT LTD; ,  FERENCZI, Szilamér Imre ,  KOVÁCS, Krisztina

Inventor： KUKOLYA, József ,  BATÁNÉ VIDÁCS, Ildikó ,  NAGY, István

IPC: C12N1/20 ,  A61K35/66 ,  A61K35/747

Abstract: The present invention provides our new isolate Lactiplantibacillus plantarum SNI3 bacterial strain, deposited as NCAIM (P) B 001482, formulation based on SNI3 strain, application of formulation on male vertebrates, breeding male and human males to favorably change their behavior and lean body mass, to decrease body fat content and increase their reproductive fitness, sperm number and testosterone level.

公开(公告)号：WO2022251455A1

公开(公告)日：2022-12-01

申请号：PCT/US2022/031075

申请日：2022-05-26

Applicant: REVELATION BIOSCIENCES, INC.

Inventor： ROLKE, James, M. ,  MARSDEN, Robin, L. ,  LYNCH, Shannan, J. ,  STEPHENS, Jackson, R. ,  NINOSKY, Joseph, M.

IPC: A61K9/00 ,  A61P37/00 ,  A61K35/66 ,  A61K39/00

Abstract: The present disclosure provides a method of treating or preventing symptoms of allergic rhinitis or chronic nasal congestion in a subject by administering to the subject an MPLA compound.

公开(公告)号：WO2022192675A1

公开(公告)日：2022-09-15

申请号：PCT/US2022/019962

申请日：2022-03-11

Applicant: TENZA, INC.

Inventor： DEBNATH, Anik ,  SHETTY, Ameet

IPC: A01N63/32 ,  A61K35/66 ,  A61K36/06 ,  C07K14/39 ,  C07K14/395

Abstract: Provided herein are signal peptides that direct secretion of expressed payload proteins in yeast. Methods of using the signal peptides for therapeutic and non-therapeutic utilities are also provided. Compositions comprising yeast comprising the signal peptides and methods of using said yeast comprising the signal peptides for therapeutic and non-therapeutic utilities are also provided. Methods to design and generate the disclosed signal peptides are also provided.

公开(公告)号：WO2022076578A1

公开(公告)日：2022-04-14

申请号：PCT/US2021/053796

申请日：2021-10-06

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： GROVER, Madhusudan

IPC: A61K35/66 ,  A61K35/74 ,  A61K38/00 ,  A61K38/55

Abstract: This document relates to methods and materials involved in treating a mammal having a gastrointestinal disorder (e.g., an irritable bowel syndrome (IBS) such as post-infection IBS (PI-IBS)). For example, one or more protease inhibitors and/or one or more microorganisms that produce one or more protease inhibitors can be administered to a mammal having, or at risk of developing, a gastrointestinal disorder to treat the mammal.

公开(公告)号：WO2021257788A1

公开(公告)日：2021-12-23

申请号：PCT/US2021/037759

申请日：2021-06-17

Applicant: FLAGSHIP PIONEERING INNOVATIONS VI, LLC

Inventor： FISHER, Adam, Barclay ,  HUBBARD, Troy, Patrick ,  SPAULDING, Caitlin, Nicole ,  AMADO, Maier Steve, Avendano

IPC: A61K35/66 ,  C12N1/08 ,  C12N1/20

Abstract: The invention provides methods for manufacturing purified preparations of achromosomal dynamic active systems (ADAS), including highly active ADAS. These ADAS provided by the invention can be obtained by a variety of means. Various associated methods of making and using these ADAS are provided.

公开(公告)号：WO2021194040A1

公开(公告)日：2021-09-30

申请号：PCT/KR2020/016195

申请日：2020-11-17

Applicant: (주)메디톡스

Inventor： 최우진 ,  김태훈

IPC: C12N1/20 ,  A61K35/66 ,  A23L33/135 ,  A61P3/00 ,  C12R1/225 ,  A23V2002/00 ,  A23V2200/326 ,  A23V2200/332 ,  C12R2001/225

Abstract: 락토바실러스 살리바리우스 LMT15-14(수탁번호 KCTC14142BP) 및 락토바실러스 플란타룸 LMT19-1(수탁번호 KCTC14141BP)로 이루어진 군으로부터 선택된 미생물 또는 그 조합 또는 그 배양물 또는 추출물, 및 그의 용도를 제공한다.

公开(公告)号：WO2021178795A1

公开(公告)日：2021-09-10

申请号：PCT/US2021/021078

申请日：2021-03-05

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： WU, Mei X.

IPC: A61N5/067 ,  A61B18/18 ,  A61B18/20 ,  A61F7/02 ,  A61F7/08 ,  A61K35/37 ,  A61K35/66

Abstract: Low level light (LLL) can be used to restore a subject's gut microbiota to a state of health. The LLL can be applied directly to the subject's abdomen and/or back, or the LLL can be applied to a feces sample obtained from the subject, which is subsequently administered back to the subject. The subject may be suffering from guy dysbiosis resulting from a variety of different types of bodily stress, such as chemotherapy or radiation therapy.

公开(公告)号：WO2021067100A1

公开(公告)日：2021-04-08

申请号：PCT/US2020/052251

申请日：2020-09-23

Applicant: MARVELBIOME, INC.

Inventor： GOVINDAN, Jothi, Amaranath ,  JAYAMANI, Elamparithi ,  CHATTER, Priti, H.

IPC: A61K35/74 ,  A61K35/66 ,  A23L33/135 ,  C12N1/20 ,  A61K35/00

Abstract: Compositions are provided that extend the lifespan of a subject, and/or reduce or delay the onset of at least one age-associated symptom or condition. In some embodiments, compositions comprise: at least one bacterial strain or extract(s) or component(s) thereof and an excipient. In some embodiments, at least one bacterial strain comprises Gluconobacter spp., Acetobacter spp., Gluconoacaetobacter spp., Acidomonas spp., Ameyamaea spp., Asaia spp., Granulibacter spp., Kozakia spp., Neoasaia spp., Neokomagataea spp., Saccharibacter spp., Swaminathania spp., Tanticharoenia spp., or a combination thereof. Methods of making and using compositions disclosed herein are also provided.

公开(公告)号：WO2020181260A1

公开(公告)日：2020-09-10

申请号：PCT/US2020/021560

申请日：2020-03-06

Applicant: ANPAC BIO-MEDICAL SCIENCE CO., LTD.

Inventor： YU, He

IPC: A61K35/66 ,  A61K35/74 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28 ,  C12N15/113

Abstract: The present invention is generally directed to a method for diagnosis, prognosis, or treatment of a cancer, by detecting or upregulating lncRNA, LINC00472 . Particularly, LINC00472 is associated with the prognosis of ER-positive breast cancer and is involved in the interplay between ERα and NF-κB.