公开(公告)号：WO2021142039A1

公开(公告)日：2021-07-15

申请号：PCT/US2021/012379

申请日：2021-01-06

申请人： CYTOMX THERAPEUTICS, INC.

发明人： HUBERT, Rene ,  KEMBALL, Christopher ,  CHALLITA-EID, Pia

IPC分类号： A61P35/00 ,  C07K16/30 ,  A61K39/395 ,  A61K2039/505 ,  A61K47/6803 ,  A61K47/6869 ,  C07K16/3069 ,  C07K2317/33 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C07K5/0205

摘要： The invention relates generally to antibodies that bind PSMA, and methods of making and using these anti-PSMA antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

公开(公告)号：WO2022235636A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/027424

申请日：2022-05-03

申请人： MERSANA THERAPEUTICS, INC.

发明人： BURGER, Robert A.

IPC分类号： A61K31/555 ,  A61K47/68 ,  A61P35/00 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6869

摘要： Disclose herein are dosing regimens for a combination of carboplatin and a targeted NaPi2b antibody-drug conjugates for treating high grade serous ovarian cancer.

公开(公告)号：WO2021142199A1

公开(公告)日：2021-07-15

申请号：PCT/US2021/012611

申请日：2021-01-08

申请人： MERSANA THERAPEUTICS, INC.

发明人： LOWINGER, Timothy B. ,  DAMELIN, Marc I. ,  TOADER, Dorin

IPC分类号： A61K47/68 ,  A61P35/00 ,  C07K16/30 ,  A61K2039/505 ,  A61K38/07 ,  A61K47/545 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6843 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6869 ,  C07K16/3069 ,  C07K16/32 ,  C07K2317/92

摘要： The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.

公开(公告)号：WO2021142029A1

公开(公告)日：2021-07-15

申请号：PCT/US2021/012364

申请日：2021-01-06

申请人： CYTOMX THERAPEUTICS, INC.

发明人： SCHLEYER, Siew ,  MENDELSOHN, Brian, A. ,  CHALLITA-EID, Pia ,  JACKSON, Dowdy ,  KEMBALL, Christopher

IPC分类号： C07K5/02 ,  C07K16/00 ,  A61K47/68 ,  A61K2039/505 ,  A61K47/6803 ,  A61K47/6869 ,  A61P35/00 ,  C07K16/3069 ,  C07K2317/33 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C07K5/0205

摘要： The invention relates generally to novel compounds of the auristatin family, to novel linkers for coupling a payload to another molecule, such a target-binding molecule, to novel linker-toxin molecules, and to novel antibody molecules that allow controlled, site-specific conjugation.

公开(公告)号：WO2021262910A2

公开(公告)日：2021-12-30

申请号：PCT/US2021/038781

申请日：2021-06-23

申请人： REGENERON PHARMACEUTICALS, INC.

发明人： HAN, Amy

IPC分类号： A61K47/68 ,  C07K5/062 ,  A61P35/00 ,  C07K16/30 ,  A61K2039/505 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6855 ,  A61K47/6869 ,  C07K16/2869 ,  C07K16/3069 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/73 ,  C07K2317/92 ,  C07K5/021

摘要： Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein (e.g., antibody) drug conjugates thereof.

公开(公告)号：WO2021142043A1

公开(公告)日：2021-07-15

申请号：PCT/US2021/012383

申请日：2021-01-06

申请人： CYTOMX THERAPEUTICS, INC.

发明人： JACKSON, Dowdy ,  SHOSTAK, Yuriy ,  KEMBALL, Christopher ,  CHALLITA-EID, Pia

IPC分类号： A61K47/68 ,  C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  A61K2039/505 ,  A61K47/6803 ,  A61K47/6869 ,  C07K16/3069 ,  C07K2317/33 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C07K5/0205

摘要： The invention relates generally to antibodies that bind SLC34A2, and methods of making and using these anti-SLC34A2 antibodies in a variety of therapeutic, diagnostic and prophylactic indications.