公开(公告)号：WO2021054927A2

公开(公告)日：2021-03-25

申请号：PCT/US2019/000039

申请日：2019-08-12

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： GUAN, Xiangming ,  NAJMI, Asidim ,  WANG, Shenggang ,  HUANG, Yue ,  SEEFELDT, Teresa ,  ALQAHTANI, Yahya

IPC: A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K47/28 ,  A61K38/00 ,  A61K47/20 ,  A61K47/6907 ,  A61K47/6911 ,  A61K49/0032 ,  A61K49/0082 ,  A61K49/0084 ,  A61K9/0019 ,  A61K9/1075 ,  C07K5/0215

Abstract: The present invention describes compositions containing cholesterol-linker-glutathione conjugates for targeting the brain by overcoming barrier entry to the CNS through the blood brain barrier (BBB), including micelle and liposome forms of such compositions. In addition, methods for treating subjects by administering such compositions are also disclosed.