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    BIOMIMETIC JOINT ON A CHIP
    1.
    发明申请
    BIOMIMETIC JOINT ON A CHIP 审中-公开

    公开(公告)号：WO2022225631A1

    公开(公告)日：2022-10-27

    申请号：PCT/US2022/021152

    申请日：2022-03-21

    Applicant: SOUTH DAKOTA BOARD OF REGENTS

    Inventor： WOOD, Scott ,  SARASWAT, Ram

    IPC: B01L3/00 ,  C12M3/00

    Abstract: A platform for culturing modular, biomimetic compositions such as tissues, cartilage, bone, synovial membrane, is accomplished through the use of a 3D printed platform with cell well, well plate frame with culture and analysis modules, coverglass bottoms for imaging, and cross-talk flow to connect tissue modules for paracrine signaling. Human chondrocytes can be generated and kept in a cell back and expanded to zonal models, osteoarthritis progression models. The use of titanium oxide nanotubes and can produce bone marrow stem cells differentiated toward osteoblasts. The synovial membrane can be modeled by an electrospun mesh, macrophages with an inducible phenotype (quiescent vs. wound repair vs. inflammatory).

    METHOD AND SYSTEM FOR MANUFACTURING MINERAL-REDUCED MICELLAR CASEIN CONCENTRATE
    4.
    发明申请
    METHOD AND SYSTEM FOR MANUFACTURING MINERAL-REDUCED MICELLAR CASEIN CONCENTRATE 审中-公开
    用于制造减少矿物含量的胶束酪蛋白浓缩物的方法和系统

    公开(公告)号：WO2017087878A1

    公开(公告)日：2017-05-26

    申请号：PCT/US2016/062899

    申请日：2016-11-18

    Applicant: SOUTH DAKOTA BOARD OF REGENTS

    Inventor： METZGER, Lloyd

    IPC: A61K38/17 ,  A23J3/10

    CPC classification number: A23J3/10 ,  A23C9/1422 ,  A23C9/1524

    Abstract: A method for forming a modified micellar casein concentrate includes providing a volume of skim milk. The method further includes performing a first filtration process on the volume of skim milk to form a micellar casein concentrate. The method includes mixing carbon dioxide with at least a portion of the micellar casein concentrate to solubilize one or more components of the micellar casein concentrate. The method includes performing an additional filtration process on the mixture of carbon dioxide and micellar casein concentrate to remove at least a portion of the one or more solubilized components of the micellar casein concentrate to form a modified micellar casein concentrate.

    Abstract translation: 用于形成改性胶束酪蛋白浓缩物的方法包括提供一定体积的脱脂牛奶。 该方法还包括对一定体积的脱脂乳进行第一过滤过程以形成胶束酪蛋白浓缩物。 该方法包括将二氧化碳与至少一部分胶束酪蛋白浓缩物混合以溶解胶束酪蛋白浓缩物的一种或多种组分。 该方法包括对二氧化碳和胶束酪蛋白浓缩物的混合物进行另外的过滤处理以除去胶束酪蛋白浓缩物的一种或多种可溶组分的至少一部分以形成改性的胶束酪蛋白浓缩物。

    HIGH SHEAR THIN FILM MACHINE FOR DISPERSION AND SIMULTANEOUS ORIENTATION-DISTRIBUTION OF NANOPARTICLES WITHIN POLYMER MATRIX
    5.
    发明申请
    HIGH SHEAR THIN FILM MACHINE FOR DISPERSION AND SIMULTANEOUS ORIENTATION-DISTRIBUTION OF NANOPARTICLES WITHIN POLYMER MATRIX 审中-公开
    高分子薄膜机用于聚合物基质中的纳米颗粒的分散和同时取向分布

    公开(公告)号：WO2016154342A1

    公开(公告)日：2016-09-29

    申请号：PCT/US2016/023820

    申请日：2016-03-23

    Applicant: SOUTH DAKOTA BOARD OF REGENTS

    Inventor： DASH, Ilchgerel ,  WINTER, Robb

    IPC: B32B5/16

    CPC classification number: B01F7/00816 ,  B01F3/14 ,  B01F15/065 ,  B01F2015/061 ,  B01F2215/0049 ,  B82Y40/00 ,  C08J3/203 ,  C08J5/005 ,  C08J2300/00

    Abstract: An improved a device and method for dispersion and simultaneous orientation of nanoparticles within a matrix is provided. A mixer having a shaft and a stator is provided. The shaft may have a rupture region and erosion region. Further, an orienter having an angled stationary plate and a moving plate are provided. The nanoparticles and the matrix are fed into the mixer. A rotational force is applied to the shaft to produce shearing forces. The shearing forces disperse and exfoliate the nanoparticles within the matrix. The dispersed mixture is outputted onto the moving plate. The moving plate is forced across the angled stationary plate to produce fully developed laminar shear flow. The fully developed laminar shear flow or the two-dimensional extensional drag flow orients the dispersed nanoparticles-matrix mixture.

    Abstract translation: 提供了一种用于分散和同时取向基质内的纳米颗粒的装置和方法。 提供具有轴和定子的混合器。 轴可能具有破裂区域和侵蚀区域。 此外，提供了具有倾斜的静止板和移动板的定向器。 将纳米颗粒和基质进料到混合器中。 旋转力施加到轴以产生剪切力。 剪切力分散和剥离基质内的纳米颗粒。 将分散的混合物输出到移动板上。 移动板被迫穿过倾斜的固定板，以产生完全发展的层流剪切流。 完全发展的层流剪切流或二维拉伸流动使得分散的纳米颗粒 - 基质混合物。

    POLYCARBONATES HAVING SUPERIOR DIELECTRIC PROPERTIES SUITABLE FOR ENERGY DENSE CAPACITORS
    6.
    发明申请
    POLYCARBONATES HAVING SUPERIOR DIELECTRIC PROPERTIES SUITABLE FOR ENERGY DENSE CAPACITORS 审中-公开
    具有适用于能量密度电容器的超级介电性能的聚碳酸酯

    公开(公告)号：WO2016137445A1

    公开(公告)日：2016-09-01

    申请号：PCT/US2015/017300

    申请日：2015-02-24

    Applicant: SOUTH DAKOTA BOARD OF REGENTS

    Inventor： BOYLES, David A. ,  BENDLER, John T. ,  FILIPOVA, Tsvetanka

    IPC: C08G64/10 ,  C07C39/367 ,  C07C39/42 ,  H01B3/42 ,  H01G4/18

    CPC classification number: C07C39/367 ,  C07C39/42 ,  C07C43/295 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C08G64/10 ,  H01B3/426 ,  H01G4/18 ,  H01G4/186 ,  H01G4/32

    Abstract: The present invention provides monomers, analogs, and/or derivatives of bisphenols substituted with one or more fluoromethyl groups. These monomers, analogs, and/or derivatives can be used to form oligomers and/or polymers, which in turn can be used to make compounds with dielectric properties suitable for dielectric materials, including for example, use in energy dense capacitors. In a preferred embodiment, the compounds can comprise a polycarbonate of a homopolymer, copolymer, and/or terpolymer of a bisphenol with one or more fluoromethyl substitution groups. In an aspect of the invention the compounds chosen can be selected based on various desired characteristics, including, for example, their energy density, glass transition temperature, dielectric loss, and/or dipole density.

    Abstract translation: 本发明提供了被一个或多个氟甲基取代的双酚的单体，类似物和/或衍生物。 这些单体，类似物和/或衍生物可用于形成低聚物和/或聚合物，其又可用于制备具有适合介电材料的介电特性的化合物，包括例如在能量密集电容器中使用。 在优选的实施方案中，化合物可以包含双酚与一个或多个氟甲基取代基的均聚物，共聚物和/或三元共聚物的聚碳酸酯。 在本发明的一个方面，所选择的化合物可以基于各种所需的特性来选择，包括例如它们的能量密度，玻璃化转变温度，介电损耗和/或偶极密度。

    COMPOSITIONS AND METHODS FOR TREATMENT OF CERVICAL AND OVARIAN CANCER
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATMENT OF CERVICAL AND OVARIAN CANCER 审中-公开

    公开(公告)号：WO2023283315A1

    公开(公告)日：2023-01-12

    申请号：PCT/US2022/036324

    申请日：2022-07-07

    Applicant: SOUTH DAKOTA BOARD OF REGENTS

    Inventor： HALAWEISH, Fathi T. ,  CHAUHAN, Subhash ,  JAGGI, Mena

    IPC: A61K31/353 ,  A61P35/00 ,  A61K31/4025

    Abstract: Provided are compositions and methods of using an anticancer agent for cancers, such as, ovarian and cervical cancer. The compositions and methods include ormeloxifene derivatives, a selective estrogen receptor modulator (SERM), for the treatment of ovarian and cervical cancers. The compositions and methods include various spectroscopy techniques and molecular modeling to produce derivative molecules comprising the ormeloxifene skeleton to enhance binding to key receptors implicated in cancer compared to ormeloxifene alone. The compositions and methods provide for reduced tumor volume and tumor weight compared to a placebo control.

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