公开(公告)号：WO2021138979A1

公开(公告)日：2021-07-15

申请号：PCT/CN2020/076550

申请日：2020-02-25

Applicant: 南京大学

Inventor： 董磊 ,  韩丛薇

IPC: A61K35/747 ,  A61K35/745 ,  A61K35/742 ,  A61K35/741 ,  A61K9/50 ,  A61K47/46 ,  A61P35/00 ,  A61K33/06 ,  A61K33/00 ,  A61K33/12 ,  A61K9/5063

Abstract: 本发明公开了一种益生菌矿物材料复合制剂，为将厌氧培养的益生菌培养液与矿物材料悬液混合后继续培养得到的微球，所述益生菌为乳酸杆菌，双歧杆菌，粪肠球菌或枯草芽孢杆菌，所述矿物材料为蒙脱石，硅藻土，高岭土，凹凸棒土或黏土颗粒。并公开了益生菌矿物材料复合制剂及矿物材料在制备抑制恶性肿瘤生长药物中的应用以及相应的抑制恶性肿瘤生长药物。通过小鼠实验，发现益生菌矿物材料复合制剂及矿物材料对恶性肿瘤有明显的抑制作用。

公开(公告)号：WO2021246967A1

公开(公告)日：2021-12-09

申请号：PCT/SG2021/050319

申请日：2021-06-03

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： BRZOZOWSKA, Agata Maria

IPC: B01J13/14 ,  A23P10/35 ,  A23L29/219 ,  A23L29/231 ,  A61K47/36 ,  A61K9/48 ,  A61K9/5063 ,  B01J13/046

Abstract: The present invention relates to a method of producing an encapsulated oil-solubleactive ingredient dissolved in oil. The method comprises mixing an oil-soluble activeingredient dissolved in oil with a solution of OSA-modified starch and a pectin stocksolution under high shear condition to form an oil-in-water emulsion and graduallyforming a suspension of microcapsules, wherein each of the microcapsules comprisesa microcapsule wall formed from the OSA-modified starch from the solution of OSA-modified starch; and adding a solution containing a cross-linker into the suspension ofmicrocapsules to cause a cross-linking reaction so as to form a cross-linked wall oneach of the microcapsules, wherein each of the microcapsules comprises the oil-solubleactive ingredient dissolved in oil, encapsulated within the cross-linked wall consisting ofOSA-modified starch cross-linked with pectin, and wherein the microcapsules aredispersible in aqueous media. The invention further relates to an encapsulated productobtainable by the method of the present invention. The encapsulated product is free ofadditional surfactant.

公开(公告)号：WO2021191268A1

公开(公告)日：2021-09-30

申请号：PCT/EP2021/057555

申请日：2021-03-24

Applicant: INIBSA GINECOLOGÍA, S.A.

Inventor： SAURA I VALLS, Marc ,  NEBOT TROYANO, Joaquín ,  ROCA I JUANES, Ramon M. ,  MALDONADO VILLEGAS, Adrià ,  COLOMBO, Giuseppe

IPC: A61K9/50 ,  A61K31/4402 ,  A61K31/4415 ,  A61K9/48 ,  A61K9/5026 ,  A61K9/5063 ,  A61K9/5078 ,  A61K9/5084 ,  A61K9/5089

Abstract: A modified release multiple unit oral dosage form of doxylamine succinate and pyridoxine hydrochloride and a process for its preparation The present invention relates to modified release multiple unit oral dosage form comprising: a first plurality of modified release pellets of doxylamine comprising: a pharmaceutically acceptable inert nucleus; an inner active coating layer comprising a doxylamine; optionally an intermediate enteric release coating layer; and an external modified release coating layer; and a second plurality of modified release pellets of pyridoxine or a pharmaceutically acceptable salt thereof comprising: a pharmaceutically acceptable inert nucleus; an inner active coating layer comprising pyridoxine or a pharmaceutically acceptable salt thereof; and an external modified release coating layer; wherein the particle size of the pharmaceutically acceptable inert nucleus of the first and the second plurality of pellets is such that at least 90% of the inert nuclei have a particle size from 300 µm to 1700 µm and a particle size variability of not more than200 µm measured by analytical sieving. It also relates to a process for its preparation and its use in therapy.