公开(公告)号：WO2022002737A1

公开(公告)日：2022-01-06

申请号：PCT/EP2021/067283

申请日：2021-06-24

Applicant: W&M GMBH

Inventor： WEINBERG, Bernhard ,  MOITZI, Heinz ,  RENK, Oliver ,  PIPPAN, Reinhard

IPC: C21D7/02 ,  A61L27/04 ,  A61L27/38 ,  A61L27/40 ,  A61L27/42 ,  C22C38/00 ,  B22F5/00 ,  B22F5/06 ,  B22F7/00 ,  C22C1/04 ,  C22C33/02 ,  A61L27/427 ,  A61L31/124 ,  B22F3/105 ,  B22F5/006 ,  B22F7/008 ,  C21D7/10 ,  C21D9/0068 ,  C22C1/0408 ,  C22C1/0483 ,  C22C18/00 ,  C22C23/00 ,  C22C33/0264 ,  C22C38/002

Abstract: The present invention relates to a composite material, in particular a composite material of metals, a process for producing a composite material, and a medical device, in particular an implant, based on the composite material. The composite material comprises at least 5 vol-% of Fe and at least 1 vol-% of Mg or Zn, wherein the composite material comprises a Mg or Zn phase and an Fe phase, wherein the average size of the Mg or Zn phase in at least one dimension is less than 20 µm, in particular less than 10 µm. The medical device, in particular an implant, may be suitable for fixing of bone fractures (as well as fractions of a tendon or a ligament, etc.) and/or corrections and may be capable of exhibiting a targeted failure representing a complete paradigm shift in the treatment of bone fractures and the like.

公开(公告)号：WO2020186267A2

公开(公告)日：2020-09-17

申请号：PCT/US2020/022992

申请日：2020-03-16

Applicant: BIOMIMETIC THERAPEUTICS, LLC

Inventor： SUNDARARAJ, Sharath ,  SHOCKLEY, Robert K. ,  YOUNG, Conan S. ,  BROWNING, Carrie

IPC: A61L27/54 ,  A61L27/56 ,  A61L27/42 ,  A61F2/28 ,  A61B17/70 ,  A61B17/88 ,  A61K38/1858 ,  A61L2300/414 ,  A61L2430/02 ,  A61L2430/38 ,  A61L27/24 ,  A61L27/425 ,  A61L27/427

Abstract: The present disclosure provides improved compositions comprising a solution of a platelet-derived growth factor and a biocompatible matrix that are useful for bone fusion procedures, such as spine fusion procedures. The compositions advantageously comprise a the PDGF solution and biocompatible matrix in about a 2:1 volume to weight (mL:g) ratio such that the compositions can be readily applied to a site of bone fusion using a syringe or cannula. In particular embodiments, the composition is useful in conjunction with a spine fusion cage in a spine fusion procedure. The present disclosure also provides methods of performing fusion procedures, such as spine fusion, and kits for fusion procedures.

公开(公告)号：WO2021120353A1

公开(公告)日：2021-06-24

申请号：PCT/CN2020/071326

申请日：2020-01-10

Applicant: 上海贝奥路生物材料有限公司

Inventor： 卢建熙 ,  卢霄 ,  王臻

IPC: A61L27/56 ,  A61L27/42 ,  A61L2430/24 ,  A61L27/427

Abstract: 一种复合多孔生物陶瓷(12)的金属假体及其制备方法，通过采用医用金属材料制备金属框架(11)；在金属框架(11)内填充造孔剂，以获得造孔构架与金属框架(11)的复合体；将预制的陶瓷浆液灌入造孔构架与金属框架(11)的复合体中，以获得陶瓷坯体与金属框架(11)的复合体；去除陶瓷坯体与金属框架(11)的复合体中的造孔剂，并经烧结之后获得多孔生物陶瓷(12)和金属的复合体。所述金属假体同时具备金属的坚固性和耐用性和多孔生物陶瓷(12)优良的组织修复功能，能够达到外科植入假体的要求，且能够为患者量身定制多孔生物陶瓷(12)和金属的复合体的形态、尺寸、机械和生物性能，可行性高、重复性好以及实用性强，能够广泛应用于生物医学和兽医领域。

公开(公告)号：WO2020263398A1

公开(公告)日：2020-12-30

申请号：PCT/US2020/029767

申请日：2020-04-24

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  THE BRIGHAM AND WOMEN'S HOSPITAL. INC.

Inventor： LANGER, Robert, S. ,  TRAVERSO, Carlo, Giovanni ,  LIU, Jinyao ,  PANG, Yan

IPC: A61L27/02 ,  A61L27/20 ,  A61L27/42 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  A61L31/02 ,  A61L31/04 ,  A61L31/12 ,  A61L31/14 ,  A61B2017/00818 ,  A61L2400/06 ,  A61L2400/12 ,  A61L27/025 ,  A61L27/427 ,  A61L31/028 ,  A61L31/042 ,  A61L31/124 ,  A61L31/145 ,  A61L31/148

Abstract: The present disclosure provides methods of forming interlayer tissue cushions (e.g., submucosal cushions) using shear-thinning hydrogels comprising an anionic polysaccharide and layered silicate and subsequent use of the cushions for removing protrusions (e.g., lesions, such as polyps or tumors) from above the cushions. Further provided are uses, methods of treatment, and kits.