公开(公告)号：WO2017144959A1

公开(公告)日：2017-08-31

申请号：PCT/IB2016/053275

申请日：2016-06-03

Applicant: SERVIÇO NACIONAL DE APRENDIZAGEM INDUSTRIAL - SENAI. ,  BHIO SUPPLY INDÚSTRIA E COMÉRCIO DE EQUIPAMENTOS MÉDICOS LTDA ,  MJM PRODUTOS FARMACEUTICOS E DE RADIOPROTEÇÃO LTDA

Inventor： ROBERTO WALTER FERREIRA, Paulo ,  MACHADO DARTORA, Caroline ,  CRISTIANO SCHREINER, Jaime ,  CARLOS PELISSARO PASIN, Maicon ,  GALILEO ANELE FILHO, Ricardo ,  SANTOS KALIKOSKI, Rodrigo ,  MARTINS DA SILVA JÚNIOR, Edison ,  MIRANDA, Ivan ,  SARAIVA DOS SANTOS, Marcelo ,  FIALHO VIANA, Alice ,  COELHO LAMACHIA MADKE, Patrícia ,  RIBEIRO MADKE, Rafael ,  CARDOSO VIDAL, Salus ,  MACHADO NABINGER, Patrícia

IPC: B01D15/08 ,  A61K51/00 ,  G01N33/53 ,  G21G7/00 ,  B01D59/30

CPC classification number: A61K51/00 ,  B01D15/08 ,  B01D59/30 ,  G01N33/53 ,  G21G7/00

Abstract: É descrito um equipamento para marcação de moléculas com Gálio-68 que realiza a eluição de todos os geradores de Gálio-68 disponíveis atualmente no mercado, através de um mesmo circuito de marcação (CM) de uso único que permite a purificação do material radioativo, de forma que este não possua contaminantes metálicos, como o Fe 3+ e Zn 2+ que possam prejudicar a marcação da molécula, dita purificação ocorrendo através da passagem do eluato de Gálio-68 por uma coluna cromatográfica, e um sistema de filtração esterilizante do radiofármaco marcado com Gálio-68, de forma que dito radiofármaco seja estéril e apirogênico.

Abstract translation:

＆ 描述了一种G-68型钼标记设备，该设备通过一种单一洗脱方式洗脱市场上所有现有的G-68发生器 （CM）一次性电路，允许净化放射性物质，使其不含金属污染物，如Fe 3+ 这可能会损害分子的标记，所述纯化是通过G-68洗脱液通过柱子而发生的 色谱法和G-68标记的杀菌放射性药物，使得放射性药物稳定且无热原性。

公开(公告)号：WO1981001802A1

公开(公告)日：1981-07-09

申请号：PCT/JP1980000326

申请日：1980-12-25

Applicant: ASAHI CHEMICAL IND ,  MIYAKE T ,  OBANAWA H ,  TAKEDA K

Inventor： ASAHI CHEMICAL IND

IPC: B01D59/30

CPC classification number: B01D59/30 ,  Y10S423/07

Abstract: A process for separating carbon isotopes, which comprises contacting an aqueous solution containing acid dissociation type and non-dissociation type chemical species of carbon-containing acids with a solid phase anion exchange resin to thereby simultaneously conduct a carbon isotope exchange reaction between said acid dissociation type chemical species and non-dissociation type chemical species and adsorb said acid dissociation type chemical species on said anion exchange resin, thus C12 and C13 being separated into the solution phase and the solid phase, respectively, or vice versa, for the concentration of C13. This process is extremely effective and can be conducted inexpensively as compared with conventional separating processes by chemical exchange between gas and liquid phases, between gas and solution phases, or between solution and solution phases.

公开(公告)号：WO2020072891A2

公开(公告)日：2020-04-09

申请号：PCT/US2019/054678

申请日：2019-10-04

Applicant: BATTELLE ENERGY ALLIANCE, LLC

Inventor： SNOW, Mathew S. ,  WARD, Jessica L.

IPC: B01D59/30

Abstract: Systems and methods for efficient, effective, and safe separation and isolation of multiple isotopes ( e.g. , Mo, Zr, Ba, Sr, Te, and lanthanide isotopes) from fission products includes use of a plurality of chromatography columns, each containing a chromatographic resin formulated to target one or more particular isotopes. The system is operable in a "series" configuration to load the multiple columns by a single pass of the sample. Then, the system may be transitioned ( e.g ., using valves) to a "parallel" configuration in which multiple columns of the system may be operated simultaneously to elute targeted isotopes. Additional parallel operations of the columns, using different eluent compositions, may be used to elute different targeted isotopes. The system may be reconditioned in preparation for a subsequent sample.

公开(公告)号：WO99048586A1

公开(公告)日：1999-09-30

申请号：PCT/US1999/006294

申请日：1999-03-25

IPC: G21F9/06 ,  B01D15/04 ,  B01D59/12 ,  B01D59/26 ,  B01D59/30 ,  B01D59/50 ,  B01D61/00 ,  B01D61/36 ,  B01D63/02 ,  B01D63/06 ,  B01D69/00 ,  B01J49/00 ,  C02F1/42 ,  C02F1/44 ,  B01D59/00 ,  B01D61/58 ,  C02F9/00

CPC classification number: C02F1/44 ,  B01D59/12 ,  B01D59/26 ,  B01D59/50 ,  B01D61/00 ,  B01D61/36 ,  B01D63/02 ,  B01D63/068 ,  B01D2313/28 ,  C02F1/42

Abstract: A process and apparatus for treating the heavy hydrogen isotope content of the contaminated water by contacting the contamined water with a molecular separation material (28) including a support medium carrying a plurality of hydration sites having associated waters of hydration, whereby a portion of the waters of hydration are replaced with heavy hydrogen isotope water molecules from the contaminated water. The hydrogen isotope water molecule content of the contaminated water is thus decreased. The molecular separation material (28) is preferably a polymer, such as a polystyrene/divinyl benzene cross-linked polymer, having hydration sites with associated waters of hydration. Preferred hydration sites are obtained by reacting the polymer which has been sulfonated or phosphonated to create reactive sites, with a salt of, for example, aluminum, sodium, magnesium, copper, zinc, cobalt, iron, nickel, manganese, potassium and chromium. Before or during contact with the molecular separation material (28), the contaminated water may be brought into contact with a separation membrane (12) selectively permeable to light water molecules relative to hydrogen isotope water molecules, to remove light water molecules from the water, thereby increasing the concentration of said hydrogen isotope molecules.

Abstract translation: 通过使被检查的水与分子分离材料（28）接触来处理污染水的重氢同位素含量的方法和装置，所述分子分离材料（28）包括承载介质，所述支持介质具有多个具有相关联的水合水合物的水合位置，由此一部分水 的水合物被来自污染水的重氢同位素水分子代替。 因此污染水的氢同位素水分子含量降低。 分子分离材料（28）优选是聚合物，例如聚苯乙烯/二乙烯基苯交联聚合物，其具有水合位点和相关的水合水合物。 优选的水合位点是通过已经磺化或膦酸化以产生反应性位点的聚合物与例如铝，钠，镁，铜，锌，钴，铁，镍，锰，钾和铬的盐反应而获得的。 在与分子分离材料（28）接触之前或期间，污染的水可以与相对于氢同位素水分子选择性地透过轻水分子的分离膜（12）接触，以从水中除去轻水分子， 从而增加所述氢同位素分子的浓度。

公开(公告)号：WO1996000123A1

公开(公告)日：1996-01-04

申请号：PCT/US1995007621

申请日：1995-06-16

Applicant: WESTINGHOUSE ELECTRIC CORPORATION

Inventor： WESTINGHOUSE ELECTRIC CORPORATION ,  SNYDER, Thomas, S. ,  PETERSON, Steven, H. ,  UMESH, Nayak, P. ,  BELESKI, Richard, J.

IPC: B01D59/30

CPC classification number: B01D59/30 ,  G01N30/58

Abstract: A process for the partial or complete simultaneous separation of isotopes of erbium, especially high thermal neutron capture cross section erbium isotopes, using continuous, steady-state, chromatography in which an ion exchange resin is the stationary phase, an aqueous solution of ions based on a mixture of erbium isotopes is the feed phase, and an aqueous acid eluant solution is the mobile phase. The process involves the mobile phase eluting or desorbing the erbium isotopic solute adsorbed on the stationary phase under conditions such that each of the various naturally occurring isotopes of erbium is primarily eluted in an elution volume distinct from the elution volumes of the other isotopes. In a preferred embodiment, the conditions are such that at least one of the elution volumes contains essentially only one isotope of erbium. The process is preferably conducted in a continuous, steady-state manner, and in particular is preferably conducted in a continuous annular chromatograph (CAC) (10).

Abstract translation: 使用其中离子交换树脂为固定相的连续稳态色谱法，部分或完全同时分离铒的特别是高热中子俘获截面铒同位素的方法，基于 铒同位素的混合物是进料相，酸性洗脱剂水溶液是流动相。 该方法包括流动相洗脱或解吸吸附在固定相上的铒同位素溶质，其条件是使得铒的各种天然存在的各种同位素主要以与其它同位素的洗脱体积不同的洗脱体积洗脱。 在优选的实施方案中，条件使得洗脱体积中的至少一个基本上仅含有铒的一个同位素。 该方法优选以连续的稳态方式进行，特别优选在连续环状色谱仪（CAC）（10）中进行。

公开(公告)号：WO2022139398A1

公开(公告)日：2022-06-30

申请号：PCT/KR2021/019479

申请日：2021-12-21

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： CHOI, Kang Hyuk ,  PARK, Ul Jae ,  LEE, Jun Sig ,  KIM, A Ran

IPC: B01D59/26 ,  B01D59/30 ,  B01D15/36 ,  B01D15/18 ,  G21G1/00

Abstract: The present invention relates to a method of producing and refining carrier-free lutetium-177 using chromatography, and more specifically to a method of producing and refining carrier-free lutetium 1-77 using chromatography having excellent resolution of lutetium and ytterbium without a concentration gradient of an eluent.

公开(公告)号：WO2015110806A1

公开(公告)日：2015-07-30

申请号：PCT/GB2015/050130

申请日：2015-01-21

Applicant: NATIONAL NUCLEAR LABORATORY LIMITED

Inventor： STANLEY, Steven J ,  MYERS, Thomas O

IPC: G01N30/46 ,  B01L3/00 ,  G01N30/60 ,  B01D59/30

CPC classification number: G01N30/461 ,  B01D15/22 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502753 ,  B01L2200/04 ,  B01L2200/082 ,  B01L2200/16 ,  B01L2300/027 ,  B01L2300/0829 ,  B01L2300/0883 ,  B01L2400/0481 ,  B01L2400/0644 ,  B01L2400/0655 ,  B01L2400/0666 ,  G01N1/405 ,  G01N30/462 ,  G01N30/6095 ,  G01N30/74 ,  G21F9/12 ,  G21F9/30 ,  G21F9/34

Abstract: The invention provides an apparatus and system for the separation and optional analysis of the components of a sample of material, the apparatus and system comprising a cartridge comprising: at least one sample inlet port, at least one resin inlet port and a multiplicity of reagent and purge fluid input ports which are fluidically connected via a multiplicity of control valves to a multiplicity of chromatographic columns which are fluidically connected together in series; and a multiplicity of outlet ports wherein each outlet port additionally comprises an outlet valve which is adapted to control the flow of fluid through said outlet ports; wherein each of said multiplicity of chromatographic columns is aligned with one of said multiplicity of outlet ports so as to allow for fluid flow from said column through said outlet port. The system optionally additionally facilitates the analysis of the components. The invention additionally provides a method for the separation of the components of a sample of material which comprises the use of the apparatus and system of the invention. The apparatus, system and method of the invention are advantageously applied to the separation and analysis of radioactive materials.

Abstract translation: 本发明提供了一种用于分离和任选分析材料样品的组件的装置和系统，该装置和系统包括：筒，包括：至少一个样品入口，至少一个树脂入口和多个试剂， 清洗流体输入端口，其经由多个控制阀流体连接到串联流体连接在一起的多个色谱柱; 和多个出口端口，其中每个出口端口另外包括适于控制通过所述出口端口的流体流动的出口阀; 其中所述多个色谱柱中的每一个与所述多个出口端口中的一个对准，以便允许流体从所述色谱柱流过所述出口。 该系统可选地另外促进了组件的分析。 本发明另外提供了一种用于分离材料样品的组分的方法，其包括使用本发明的装置和系统。 本发明的装置，系统和方法有利地应用于放射性物质的分离和分析。

公开(公告)号：WO2008101311A1

公开(公告)日：2008-08-28

申请号：PCT/CA2007/000272

申请日：2007-02-22

Applicant: BIOVECTRA INC. ,  MONTHONY, James, F. ,  YANG, Li ,  KERSHAW, Kurt, E. ,  WINSLOW, Christopher, D. ,  RILEY, John, G.

Inventor： MONTHONY, James, F. ,  YANG, Li ,  KERSHAW, Kurt, E. ,  WINSLOW, Christopher, D. ,  RILEY, John, G.

IPC: C08L29/02 ,  B01D59/30 ,  C08F6/12 ,  C08G65/30 ,  G01N33/44

CPC classification number: C08F8/44 ,  B01D15/361 ,  B01J47/12 ,  C08F6/003 ,  C08G65/30 ,  C08G65/3326 ,  C08G65/3346 ,  G01N30/02 ,  Y10T436/255

Abstract: A process for purification of water soluble polymers is provided. A polymer of interest can be separated from a mixture of polymers, provided the polymer of interest differs from other polymers in the mixture in the number of reactive terminal groups. The process involves derivatizing polymers at the reactive terminal groups with a derivatizing molecule, bearing either (i) two or three cationic or anionic ionizable groups, and a group capable of covalent bonding to the reactive terminal groups or (ii) three or four ionizable groups, at least one of which is capable of covalent bonding to the reactive terminal groups; followed by ion exchange. The process allows removal of PEG from MPEG, and can be used for polymers having an average size greater than 9,000 Da Derivatization may be reversible in order to allow re-use of recovered contaminant polymers.

Abstract translation: 提供了一种用于纯化水溶性聚合物的方法。 感兴趣的聚合物可以从聚合物的混合物中分离出来，只要所关心的聚合物与反应性末端基团数目的混合物中的其它聚合物不同。 该方法包括用衍生化分子衍生化反应性末端基团的聚合物，该衍生化分子带有（i）两个或三个阳离子或阴离子可离子基团，以及能够与反应性末端基团共价结合的基团，或（ii）三个或四个可离子化基团 ，其中至少一个能够与反应性末端基团共价结合; 然后进行离子交换。 该方法允许从MPEG去除PEG，并且可以用于平均尺寸大于9,000Da的聚合物。衍生化可以是可逆的，以便允许再利用回收的污染物聚合物。

公开(公告)号：WO98032513A2

公开(公告)日：1998-07-30

申请号：PCT/US1998/001600

申请日：1998-01-28

IPC: G21G4/08 ,  B01D15/04 ,  B01D59/30 ,  B01J20/22 ,  B01J20/26 ,  B01J41/04 ,  B01J49/00 ,  C01G29/00 ,  C01G30/00 ,  C22B30/06 ,  B01J41/00 ,  G01N30/96

CPC classification number: C01G30/001 ,  C22B3/42 ,  C22B30/06 ,  Y02P10/234

Abstract: A method for separating Bi from a solution of radionuclides wherein the solution contains a concentration of the chloride ions and hydrogen ions adjusted to allow the formation of a chloride complex. The solution is then brought into contact with an anion exchange resin, whereupon Bi is absorbed from the solution and adhered onto the anion exchange resin in the chloride complex. Other non-absorbing radionuclides such as Ra, Ac, and Fr, along with HCl are removed from the anion exchange resin with a scrub solution. The Bi is removed from the anion exchange resin by washing the anion exchange resin with a stripping solution free of chloride ions and with a reduced hydrogen ion concentration which breaks the chloride anionic complex, releasing the Bi as a cation. In a preferred embodiment of the present invention, the anion exchange resin is provided as a thin membrane, allowing for extremely rapid adherence and stripping of the Bi. A preferred stripping solution for purification of Bi for use in medical applications includes sodium acetate, pH 5.5. A protein conjugated with bifunctional chelating agents in vivo with the Na0Ac, to receive the Bi as it is being released from the anion exchange resin.

Abstract translation: 一种从放射性核素溶液中分离Bi的方法，其中溶液含有调节氯离子和氢离子浓度以形成氯化物络合物。 然后使溶液与阴离子交换树脂接触，于是从溶液中吸收Bi并附着到氯化物络合物中的阴离子交换树脂上。 使用洗涤溶液从阴离子交换树脂中除去其它非吸收性放射性核素，例如225Aa，225Ae，和221Ce，以及HCl。 通过用不含氯离子的汽提溶液洗涤阴离子交换树脂和降低氢离子浓度，使阴离子交换树脂从阴离子交换树脂中除去，从而破坏了氯化物阴离子络合物，从而释放出Bi作为阳离子。 在本发明的一个优选实施方案中，阴离子交换树脂被提供为薄膜，允许极快的粘附和剥离。 用于纯化用于医疗应用的Bi的优选剥离溶液包括pH 5.5的乙酸钠。 与NaOAc体内与双功能螯合剂缀合的蛋白质，从阴离子交换树脂中释放出来接受<213> Bi。

公开(公告)号：WO2014172360A2

公开(公告)日：2014-10-23

申请号：PCT/US2014/034182

申请日：2014-04-15

Applicant: KURION, INC.

Inventor： DENTON, Mark S. ,  SHMAYDA, Walter T.

IPC: B01D59/30

CPC classification number: B01D59/28

Abstract: Systems, methods, and processes for a high throughput, low concentration processing of low activity tritiated light water include the electrolysis of at least some of the tritiated water to produce hydrogen and tritium gas. The hydrogen and tritium gas produced by electrolysis in some cases are combined with heated water vapor to increase throughput and passed through a liquid phase catalytic exchange column, which generally includes a catalyst that includes palladium coated with a hydrophobic polymer. As the hydrogen and tritium gas, along with heated water vapor, rise through the LPCE column, the tritium is retained on the catalyst. Deionized wash water passes down the column (i.e., in the opposite direction of the flow of the hydrogen gas and heated water vapor) and carries the retained tritium out of the LPCE column.

Abstract translation: 低活性氚化轻水的高通量，低浓度处理的系统，方法和方法包括至少一些氚化水的电解以产生氢和氚气。 通过电解产生的氢气和氚气在一些情况下与加热的水蒸汽结合以增加生产量并通过液相催化交换柱，其通常包括包含用疏水性聚合物涂覆的钯的催化剂。 由于氢气和氚气体以及加热的水蒸汽通过LPCE柱上升，氚保留在催化剂上。 去离子的洗涤水通过柱（即，在与氢气和加热的水蒸汽的流动的相反方向）下运送并将保留的氚输出LPCE柱。