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    METHOD OF ENCAPSULATION OF AN ACTIVE PROTEIN USING ELECTRODEPOSITION TECHNIQUES, |AN ANTIBACTERIAL COMPOSITION CONTAINING THE ACTIVE PROTEIN AND POLYMER AND ITS|USE FOR THE PRODUCTION OF VETERINARY MEDICINAL PRODUCTS
    2.
    发明申请
    METHOD OF ENCAPSULATION OF AN ACTIVE PROTEIN USING ELECTRODEPOSITION TECHNIQUES, |AN ANTIBACTERIAL COMPOSITION CONTAINING THE ACTIVE PROTEIN AND POLYMER AND ITS|USE FOR THE PRODUCTION OF VETERINARY MEDICINAL PRODUCTS 审中-公开

    公开(公告)号：WO2022009136A2

    公开(公告)日：2022-01-13

    申请号：PCT/IB2021/056130

    申请日：2021-07-08

    Applicant: BIOCELTIX SPOLKA AKCYJNA

    Inventor： BZDZION, Lukasz ,  GRZESIAK, Jakub ,  WRZESZCZ, Karol ,  JUNKA, Adam

    IPC: A61K35/28 ,  A61K8/11 ,  A61K45/06 ,  A61P31/04 ,  C07K14/47 ,  C11D3/37 ,  C11D17/00 ,  C07K14/4723 ,  C11D17/0039 ,  C11D3/3753

    Abstract: The subject of invention is a method of encapsulating an active protein using electrodeposition techniques, characterised in that it comprises the following steps: (a) establishing a primary mesenchymal cell culture containing 2,000-5,000 source tissue cells and a serum-supplemented culture medium; (b) maintaining the cell culture established in step (a) for 280-340 hours until the culture surface is fully covered by the cultured cells; (c) obtaining a culture fluid from the above of the cultured cells; (d) purifying the culture fluid obtained in step (c) from cell debris and suspended cells by centrifuging said fluid with a force of 300 to 1200 x g; (e) transferring the upper liquid phase from above the sediment to a new vessel; (f) gently mixing the purified liquid phase obtained in step (e) with an aqueous solution of polyvinyl alcohol; (g) adding ethyl alcohol to the mixture obtained in step (f) while stirring continuously; (h) the material obtained in step (g) is deposited on the collector surface by means of electro spinning or electrospraying. Another subject of invention is an antibacterial composition containing an active protein and a polymer, characterised in that it contains ethyl alcohol, wherein the active protein is a fibrous, fully water-soluble material containing proteins released by mesenchymal cells, including cathelicidin at an amount from 270 to 1230 pg/100mg of dry weight of the composition, and the polymer is an aqueous solution of polyvinyl alcohol. Another subject of invention is an use of the antibacterial composition according to invention for the preparation of veterinary medicinal products.

    WASCH- ODER REINIGUNGSMITTEL
    3.
    发明申请
    WASCH- ODER REINIGUNGSMITTEL 审中-公开

    公开(公告)号：WO2022207593A1

    公开(公告)日：2022-10-06

    申请号：PCT/EP2022/058195

    申请日：2022-03-29

    Applicant: HENKEL AG & CO. KGAA

    Inventor： FREY, Till ,  GEBERT-SCHWARZWAELDER, Antje ,  KREIS, Michael ,  KURTH, Oliver

    IPC: C11D3/37 ,  C11D3/20 ,  C11D17/00 ,  C11D11/00 ,  C11D11/0023 ,  C11D17/003 ,  C11D3/2065 ,  C11D3/3753

    Abstract: Die Erfindung betrifft Wasch- oder Reinigungsmittel, bevorzugt Geschirrspülmittel, insbesondere maschinellen Geschirrspülmittel, umfassend mindestens ein Gel, bevorzugt ein bei Raumtemperatur (20 °C) festes Gel, umfassend, jeweils bezogen auf das Gesamtgewicht des Gels: d) 2 bis 40 Gew.-%, bevorzugt 3 bis 20 Gew.-%, insbesondere 5 bis 18 Gew.-%, besonders bevorzugt 7 bis 16 Gew.-% PVOH und/oder dessen Derivate; e) 1 bis 60 Gew.-%, bevorzugt 10 bis 45 Gew.-% mindestens eines Polyalkylenglykols, bevorzugt mindestens eines Polyethylenglykols und/oder mindestens eines Polypropylenglykols, sowie Mischungen daraus; f) 30 bis 65 Gew.-% Glycerin.

    WASCH- ODER REINIGUNGSMITTEL
    4.
    发明申请
    WASCH- ODER REINIGUNGSMITTEL 审中-公开

    公开(公告)号：WO2022207590A1

    公开(公告)日：2022-10-06

    申请号：PCT/EP2022/058190

    申请日：2022-03-29

    Applicant: HENKEL AG & CO. KGAA

    Inventor： FREY, Till ,  KREIS, Michael ,  SCHMIEDEL, Peter ,  GEBERT-SCHWARZWAELDER, Antje

    IPC: C11D3/37 ,  C11D11/00 ,  C11D17/00 ,  C11D11/0023 ,  C11D17/003 ,  C11D3/3753

    Abstract: Die Erfindung betrifft spezielle Wasch- oder Reinigungsmittel, umfassend mindestens ein Gel, bevorzugt ein bei Raumtemperatur (20 °C) festes Gel, umfassend, jeweils bezogen auf das Gesamtgewicht des Gels, 3 bis 40 Gew.-%, bevorzugt 4 bis 20 Gew.-%, insbesondere 5 bis 18 Gew.-%, PVOH und/oder dessen Derivate; sowie a. mindestens einer Komponente mit einem Parameter r = 16,3 MPa1/2; sowie c. optional mindestens einen weiterer Aktivstoff, bevorzugt ausgewählt aus Farbstoffen, Glaskorrosionsinhibitoren, Parfüms, pH-Stellmitteln sowie weiteren Prozesshilfsmitteln; wobei mindestens eine der Komponenten gemäß a) oder b) bei 20 °C flüssig ist.

    METHOD OF ENCAPSULATION OF AN ACTIVE PROTEIN USING ELECTRODEPOSITION TECHNIQUES, AN ANTIBACTERIAL COMPOSITION CONTAINING THE ACTIVE PROTEIN AND A POLYMER, AND ITS USE FOR THE PRODUCTION OF MEDICATIONS INTENDED FOR HUMANS
    7.
    发明申请
    METHOD OF ENCAPSULATION OF AN ACTIVE PROTEIN USING ELECTRODEPOSITION TECHNIQUES, AN ANTIBACTERIAL COMPOSITION CONTAINING THE ACTIVE PROTEIN AND A POLYMER, AND ITS USE FOR THE PRODUCTION OF MEDICATIONS INTENDED FOR HUMANS 审中-公开

    公开(公告)号：WO2022009135A2

    公开(公告)日：2022-01-13

    申请号：PCT/IB2021/056129

    申请日：2021-07-08

    Applicant: BIOCELTIX SPOLKA AKCYJNA

    Inventor： BZDZION, Lukasz ,  GRZESIAK, Jakub ,  WRZESZCZ, Karol ,  JUNKA, Adam

    IPC: A61K35/28 ,  A61K8/11 ,  A61K45/06 ,  A61P31/04 ,  C07K14/47 ,  C11D3/37 ,  C11D17/00 ,  A61K8/34 ,  A61K8/64 ,  A61K8/8129 ,  A61Q17/005 ,  C07K14/4723 ,  C11D17/0039 ,  C11D3/3753

    Abstract: The subject of invention is a method of encapsulating an active protein using electrodeposition techniques, characterised in that it comprises the following steps: (a) establishing a primary mesenchymal cell culture containing 2,000-5,000 source tissue cells and a serum-supplemented culture medium; (b) maintaining the cell culture established in step (a) for 280-340 hours until the culture surface is fully covered by the cultured cells; (c) obtaining a culture fluid from the above of the cultured cells; (d) purifying the culture fluid obtained in step (c) from cell debris and suspended cells by centrifuging said fluid with a force of 300 to 1200 x g; (e) transferring the upper liquid phase from above the sediment to a new vessel; (f) gently mixing the purified liquid phase obtained in step (e) with an aqueous solution of polyvinyl alcohol; (g) adding ethyl alcohol to the mixture obtained in step (f) while stirring continuously; (h) the material obtained in step (g) is deposited on the collector surface by means of electro spinning or electrospraying. Another subject of invention is an antibacterial composition containing an active protein and a polymer, characterised in that it contains ethyl alcohol, wherein the active protein is a fibrous, fully water-soluble material containing proteins released by mesenchymal cells, including cathelicidin at an amount from 270 to 1230 pg/100mg of dry weight of the composition, and the polymer is an aqueous solution of polyvinyl alcohol. Another subject of invention is an use of the antibacterial composition according to invention for the preparation of medications intended for humans.

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