COMPOSITIONS AND METHODS FOR PROTECTING ORGANS FROM ISCHEMIA/REPERFUSION INJURY ASSOCIATED WITH TRANSPLANTATION
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR PROTECTING ORGANS FROM ISCHEMIA/REPERFUSION INJURY ASSOCIATED WITH TRANSPLANTATION 审中-公开
    用于保护器官免于与移植相关的缺血/再灌注损伤的组合物和方法

    公开(公告)号:WO2017214039A1

    公开(公告)日:2017-12-14

    申请号:PCT/US2017/035960

    申请日:2017-06-05

    Abstract: The invention provides compositions and methods for protecting organs, such as lungs, from injury associated with transplantation. Specifically, the invention relates to secoisolaricirecinol diglucoside (SDG), including natural SDG, synthetic SDG (LGM2605), (S,S)-SDG, (R,R)-SDG and mixtures thereof, as well as related molecules, for protectinglungs from injury, such as ischemia/reperfusion injury, associated with transplantation.

    Abstract translation: 本发明提供了用于保护器官例如肺免于与移植相关的损伤的组合物和方法。 具体而言,本发明涉及包含天然SDG,合成SDG(LGM2605),(S,S)-SDG,(R,R)-SDG及其混合物以及相关分子的开环异喹啉二葡萄糖苷(SDG) 损伤,如与移植相关的缺血/再灌注损伤。

    COMPOSITION FOR TREATMENT OF OXIDATIVE STRESS AND CARDIOVASCULAR DISEASE
    5.
    发明申请
    COMPOSITION FOR TREATMENT OF OXIDATIVE STRESS AND CARDIOVASCULAR DISEASE 审中-公开
    用于治疗氧化应激和心血管疾病的组合物

    公开(公告)号:WO2016189345A1

    公开(公告)日:2016-12-01

    申请号:PCT/IB2015/000870

    申请日:2015-06-05

    Abstract: The present invention, in some embodiments, is a composition that includes 35 to 50 weight percent of a first vegetable oil having a saturated fatty acid content of 4% to 12%, 35 to 50 weight percent of a second vegetable oil having an alpha-linolenic acid content of 45 % to 65%, 0.005 to 0.15 weight percent of at least one of Vitamin A and Vitamin D, 2 to 10 weight percent of at least one phytosterol; and 0.02 to 0.2 weight percent of an antioxidant including, but not limited to, tocopherol, ascorbyl palmitate, Rosemary extract and mixtures thereof. The present invention further includes, in some embodiments, us of a composition for treating oxidative stress and cardiovascular diseases.

    Abstract translation: 在一些实施方案中,本发明是包含35至50重量%的饱和脂肪酸含量为4%至12%的第一植物油,35至50重量%的具有α- 亚麻酸含量为45%至65%,维生素A和维生素D中的至少一种为0.005至0.15%,至少一种植物甾醇为2至10%重量; 和0.02至0.2重量%的抗氧化剂,包括但不限于生育酚,抗坏血酸棕榈酸酯,迷迭香提取物及其混合物。 在一些实施方案中,本发明还包括用于治疗氧化应激和心血管疾病的组合物。

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