公开(公告)号：WO2023025400A1

公开(公告)日：2023-03-02

申请号：PCT/EP2021/073793

申请日：2021-08-27

Applicant: SHIMADZU CORPORATION ,  SHIMADZU RESEARCH LABORATORY (EUROPE) LTD.

Inventor： DING, Li ,  RUSINOV, Aleksandr

IPC: H01J49/02 ,  H01J49/00

Abstract: A method of processing data determined from an image-charge/current signal representative of ions of a given charge state (Q) undergoing oscillatory motion of a respective oscillation frequency (f) within an ion analyser apparatus. A data set comprises a measured signal frequency (f0) common to a plurality of a measured image-charge/current signals and a plurality of estimated ion charge values corresponding to respective amplitudes of each one of the plurality of measured image-charge/current signals. An integer charge value ([Qi]) is generated corresponding to a said estimated ion charge value rounded to the nearest integer value. Using the integer charge value ([Qi]) a plurality of different candidate image-charge/current signal frequency values (fiCand) are calculating according to said selected measured signal frequency (f0) and according to a corresponding one of one or more different candidate charge states of ion (e.g., protonation) and/or of ion isotope or isotopologue. The calculated plurality of different candidate image-charge/current signal frequency values (fiCand) are compared to a plurality of different signal frequencies (f) of the measured image-charge/current signals and a score value is calculated representing a degree of similarity therebetween according to the comparison. The charge state (Q) of the ion undergoing oscillatory motion of said selected measured signal frequency (f0), is then determined to be equal to the integer charge value ([Q̂l]) if the score value matches or exceeds a threshold score value.

公开(公告)号：WO2022269471A1

公开(公告)日：2022-12-29

申请号：PCT/IB2022/055723

申请日：2022-06-20

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： FAUR, Manuel ,  GERA, Tiberiu ,  TUDOR, Andrei

IPC: H01J49/02 ,  G01N27/624 ,  H01J49/022

Abstract: Systems and methods are disclosed for RF amplitude auto-calibration for mass spectrometry. As non-limiting examples, various aspects of this disclosure provide in a mass spectrometer comprising an RF gain block, a peak detector, and a controller: applying a DC voltage to the coil using the controller; measuring a DC calibration voltage using the peak detector; applying an RF voltage to the RF gain block using the controller; measuring an RF calibration voltage; calculating an RF calibration factor based on the measured calibration voltages using the controller; and during operation, and applying a combined RF and DC signal to the RF gain block based on the RF calibration factor. The DC voltage may be generated utilizing a first signal sent from the controller to the RF gain block via a DC amplifier.

公开(公告)号：WO2022243776A1

公开(公告)日：2022-11-24

申请号：PCT/IB2022/054080

申请日：2022-05-03

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： SIMMONS, Douglas Arnold ,  BLOOMFIELD, Nic G. ,  JIN, Wen

IPC: H01J49/00 ,  H01J49/02

Abstract: A mass spectrometer that includes an MCP detector selects and analyzes a calibrant compound that has a first isotope and a second isotope with a known abundance ratio. The mass spectrometer measures the intensity of the first isotope that produces multiple-ion strikes at the MCP detector and the intensity of the second isotope that produces single-ion strikes at the MCP detector while the bias voltage of the MCP detector is stepped through a sequence of one or more different voltages. At each step, the ratio of the measured intensities is compared to the known abundance ratio for the two isotopes. When the measured ratio is within a predetermined threshold of the known abundance ratio, an optimum voltage for the MCP detector is calculated using one or more measured ratios calculated for voltages of the sequence of voltages.

公开(公告)号：WO2022214815A1

公开(公告)日：2022-10-13

申请号：PCT/GB2022/050871

申请日：2022-04-07

Applicant: HGSG LTD

Inventor： HOYES, John Bryan

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/42

Abstract: A charge detection mass spectrometer, CDMS, is described. The CDMS comprises: an electrostatic sector field ion trap and an inductive charge detector, wherein the electrostatic sector field ion trap is configured to define, at least in part, an ion path via the inductive charge detector; and a fragmentation device. A method is also described.

公开(公告)号：WO2022200090A1

公开(公告)日：2022-09-29

申请号：PCT/EP2022/056452

申请日：2022-03-14

Applicant: ATEQ

Inventor： MAY, Thierry

IPC: G01M3/20 ,  H01J49/02 ,  H01J49/30

Abstract: La présente invention se rapporte à un spectromètre de masse (10) pour la détection de fuites par gaz traceur, ledit spectromètre (10) comprenant: - un moyen d'ionisation (3) destiné à ioniser ledit gaz traceur; - au moins une source de champ magnétique (501) engendrant un champ magnétique (I) dépendant du courant électrique I alimentant ladite source (501) destiné au tri des éléments ionisés; - un moyen de détection (7) dudit gaz traceur ionisé; caractérisé en ce que ledit spectromètre comprend un moyen de réglage du champ magnétique (II), ledit moyen de réglage étant configuré pour permettre au moins deux réglages distincts, lesdits réglages présentant une sensibilité différente.

公开(公告)号：WO2021207494A1

公开(公告)日：2021-10-14

申请号：PCT/US2021/026383

申请日：2021-04-08

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JARRELL, Joseph A. ,  GILAR, Martin

IPC: H01J49/02 ,  G01N27/62 ,  G01N33/48

Abstract: An ion detector comprises a surface configured to receive one or more ions and a detector configured to detect one or more ions by detecting electromagnetic radiation scattered by one or more ions at the surface.

公开(公告)号：WO2021180653A1

公开(公告)日：2021-09-16

申请号：PCT/EP2021/055787

申请日：2021-03-08

Applicant: LEYBOLD GMBH

Inventor： ALIMAN, Michel ,  LAUE, Alexander

IPC: G01N27/622 ,  H01J49/02 ,  H01J49/26 ,  G01N15/06 ,  G01N15/14

Abstract: The invention relates to a particle detector (1), comprising: a measuring electrode (6) for measuring charged particles (2), a detection device (7) for detecting the charged particles (2) measured by the measuring electrode (6), and an evaluation device (8) for determining the number (QN) of charged particles (2) detected by the detection device (7). The detection device (7) has a charge amplifier (6) for converting a charge signal (Q(t)) generated by the charged particles (2) into a voltage signal (U(t)) and an amplifier device (10) for amplifying the voltage signal (U(t)).

公开(公告)号：WO2020117292A1

公开(公告)日：2020-06-11

申请号：PCT/US2019/013285

申请日：2019-01-11

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： JARROLD, Martin F. ,  BOTAMANENKO, Daniel

IPC: H01J49/02 ,  H01J49/42

Abstract: A charge detection mass spectrometer may include an ion source, an electrostatic linear ion trap (ELIT) including a charge detection cylinder disposed between a pair of coaxially aligned ion mirrors, means for selectively establishing electric fields within the ion mirrors configured to cause the trapped ions in the ELIT to oscillate back and forth between the ion mirrors each time passing through the charge detection cylinder, and means for controlling a trajectory of the beam of ions entering the ELIT to cause the subsequently trapped ions to oscillate with different planar ion oscillation trajectories angularly offset from one another about the longitudinal axis with each extending along and crossing the longitudinal axis in each of the ion mirrors or with different cylindrical ion oscillation trajectories radially offset from one another about the longitudinal axis to form nested cylindrical trajectories each extending along the longitudinal axis.

公开(公告)号：WO2019236143A1

公开(公告)日：2019-12-12

申请号：PCT/US2019/013284

申请日：2019-01-11

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： JARROLD, Martin F. ,  ALEXANDER, Andrew W. ,  TODD, Aaron R.

IPC: H01J49/02 ,  H01J49/42

Abstract: A charge detection mass spectrometer (CDMS) including charge detector reset or calibration may include an electrostatic linear ion trap (ELIT) having a charge detection cylinder disposed between first and second ion mirrors, a charge generator for generating free charges, a field free region between the charge generator and the charge detection cylinder, and a processor configured to control the charge generator to generate a target number of free charges and cause the target number of free charges to travel across the field-free region and into contact with the charge detection cylinder to deposit the target number of free charges thereon and thereby calibrate or reset the charge detection cylinder to a corresponding target charge level.

公开(公告)号：WO2019229469A1

公开(公告)日：2019-12-05

申请号：PCT/GB2019/051510

申请日：2019-05-31

Applicant: MICROMASS UK LIMITED

Inventor： BUCKLEY, Frank ,  SMITH, Roger

IPC: H01J49/40 ,  H01J49/02

Abstract: A drive unit for driving an acceleration electrode of a mass spectrometer is disclosed. The drive unit includes a power converter comprising a switching element and pulsing circuitry that can form output pulses suitable for driving an acceleration electrode of a mass spectrometer. The drive unit also includes a controller that is configured to synchronise operation of the switching element with the pulsing circuitry.