US10473894B2
An optical system may include: a first lens having positive refractive power facing an object, the first lens having a first convex face facing the object; a second lens having positive refractive power, the second lens having a second convex face facing the object; a third lens having negative refractive power, the third lens having a third concave face facing an image sensor; a fourth lens adjacent to the third lens; a fifth lens adjacent to the fourth lens, the fifth lens having a fourth face facing the object, the fourth face being convex where the fifth lens intersects the optical axis; and a sixth lens adjacent to the fifth lens. The characteristics of the optical system satisfy equation, 0.4
US10473892B2
The invention discloses a six-piece optical lens for capturing image and a six-piece optical module for capturing image. In order from an object-side surface to an image-side surface, the optical lens along the optical axis comprises a first lens with refractive power; a second lens with refractive power; a third lens with refractive power; a fourth lens with refractive power; a fifth lens with refractive power; a sixth lens with refractive power, and at least one of the image-side surface and object-side surface of each of the six lens elements is aspheric. The optical lens can increase aperture value and improve the imagining quality for use in compact cameras.
US10473890B2
An image sensor includes a pixel portion in which a plurality of unit pixels each having one micro lens and a plurality of photoelectric conversion portions are arrayed in a matrix, a signal readout portion that reads out signals accumulated in the photoelectric conversion portions and converts the read signals to digital signals, a signal processor that processes signals read out by the signal readout portion and has an image capture signal processor that performs signal processing for generating a captured image on signals read out by the signal readout portion and a focus detection signal processor that performs signal processing for focus detection on signals read out by the signal readout portion, and an output portion that outputs signals processed by the signal processor.
US10473873B2
A fiber optic enclosure system (100) includes an enclosure (102), a plurality of fiber optic adaptors (132), and a drawer (130). The enclosure (102) defines an enclosure chamber (108). The plurality of fiber optic adaptors (132) is arranged on the enclosure (102). The drawer (130) is used to route an optical fiber main cable (90) within the drawer (130). The drawer (130) is removably inserted into the enclosure chamber (108).
US10473868B2
Disclosed are optical plug connectors that can be converted from a first mating interface to a second mating interface that is different than the first mating interface. The optical plug connector comprises a plug body, a shroud, a ferrule and a first coupling member for securing the optical plug connector. The shroud comprises a first mating interface configuration that may be removed and replaced with a shroud having a second mating interface configuration.
US10473862B2
A steerable optical transmit and receive terminal includes a MEMS-based N×1 optical switch network. Each optical switch in the optical switch network uses an electrostatic MEMS structure to selectively position a translatable optical grating close to or far from an optical waveguide. In the close (“ON”) position, light couples between the translatable optical grating and the optical waveguide, whereas in the far (“OFF”) position, no appreciable light couples between the translatable optical grating and the optical waveguide. The translatable optical grating is disposed at or near a surface of the optical switch network. Thus, the translatable optical grating emits light into, or receives light from, free space. The steerable optical transmit and receive terminal also includes a lens and can steer a free space optical beam in a direction determined by which port of the N×1 optical switch network is ON.
US10473854B2
The present invention discloses a high-contrast photonic crystal AND logic gate, comprising a five-port two-dimensional photonic crystal, a nonlinear cavity unit and a Y-shape AND logic gate unit; and it includes a reference-light input port, two signal-input ports, a system signal-output port and an idle port; the nonlinear cavity unit is coupled with the Y-shape AND logic gate unit. The structure of the present invention, which is compact in structure and ease of integration with other optical logic elements, not only can realize the functions of the high-contrast photonic and logic gate, but also has high contrast of high and low logic output; and is widely applicable to optical communication bands.
US10473851B2
The present invention provides an optical film. The optical film includes a first light-guiding layer, a second light-guiding layer, and at least one light absorption member. The first light-guiding layer has a first light incident surface, a first light-emitting surface, and an accommodating recessed portion formed on the first light incident surface. The second light-guiding layer is disposed on the first light incident surface, and has a second light incident surface, a second light-emitting surface, and a light-guiding member formed on the second light-emitting surface. Each light-guiding member is disposed on each accommodating recessed portion respectively, and each light-guiding member has a top portion, a bottom portion, and a side surface connecting the top portion and the bottom portion. The side surface of the light-guiding member faces the inner wall surface of the accommodating recessed portion, and the bottom portion of the light-guiding member corresponds to the opening of the accommodating recessed portion. The light absorption member covers the side surface. The first light-guiding layer has a first refractive index, and the second light-guiding layer has a second refractive index less than the first refractive index.
US10473846B2
An illumination system includes a lightguide having light extractors. A first light source is disposed at an end face of the lightguide. Light emitted by the first light source is extracted from the lightguide by the light extractors and exits the lightguide primarily along a first direction different than the length direction. A second light source is disposed along the length of the lightguide. Light emitted by the second light source enters the lightguide from a first side surface and exits the lightguide from a different second side surface along a second direction different than the first and length directions. Light emitted by the second light source has a first divergence in a first plane before entering the lightguide through the first side surface and a different second divergence in the first plane after exiting the lightguide from the second side surface.
US10473840B2
An optical fiber covering structure includes an optical fiber and a covering layer surrounding the optical fiber. The covering layer includes a glass fiber layer formed with an assembly of glass fibers or a ceramic fiber layer formed with an assembly of ceramic fibers. The glass fibers or the ceramic fibers each contains at least one fluorescent material and/or at least one light-diffusing material.
US10473808B2
An acoustic logging tool includes a first acoustic transducer and a second acoustic transducer. At least a portion of the first transducer is parallel with the second transducer. The first and second acoustic transducers are configured to propagate an acoustic signal in the same direction. The first acoustic transducer is configured to generate an acoustic output having a different frequency than the second acoustic transducer.
US10473806B2
A seismic data collection system is disclosed. The system may include at least a first housing and a second housing. The first housing may be configured to detachably couple to the second housing. The system mays also include various components such as one or more seismic sensors, a clock, or memory. Each of the components may be arranged in one of the first housing or second housing.
US10473797B2
An apparatus for detecting radiation for obtaining density information of a structure, the apparatus including: at least one detector (10), the detector (10) including: a scintillator (12) including a scintillating material for emitting light in response to incident radiation (14), and a photodetector (16) for receiving light emitted by the scintillating material (12) and outputting an electrical signal in response to light received from the scintillating material (12), wherein the photodetector (16) includes at least one silicon photomultiplier (16a). The invention reduces the volume of the apparatus and therefore provides particular advantages for use in scanning pipelines and other structures located deep subsea.
US10473796B2
A scintillator module for a CT detector includes an array of pixelated scintillators extending in a first direction at a first spacing, and extending in a second direction at a second spacing, a reflector on the array and between the pixelated scintillators, the reflector having a first thickness and forming notches having a second thickness that is greater than the first thickness. The module includes an anti-scatter grid having plates, each plate extending along a length such that, when the CT detector is positioned in a CT system, the length of the plates extend approximately toward a focal spot. The plates are separated from one another at one of the first spacing and the second spacing, and two of the notches have a gap therebetween that engages one of the plates. An adhesive positioned in the gap to adhere the one plate to the reflector.
US10473794B2
A radiation detection device (10) comprising a data processor (14) arranged to be communicatively coupled to a position sensor (16) mounted on an unmanned vehicle and a solid state radiation sensor (18) mounted on the unmanned vehicle. The data processor is configured to receive position data from the position sensor, receive radiation data from the solid state radiation sensor and periodically associate the position data with radiation data to form combined data.
US10473791B1
The present invention provides a ground-based augmentation system (GBAS) integrity performance evaluation method based on a pseudorange error distribution model, including: an airborne receiver terminal performing GBAS integrity performance evaluation by acquiring pseudorange error sample data, including the following method steps: a) grouping the pseudorange error sample data; b) building a distribution model having a Gaussian kernel and quadratic Gaussian polynomial tails for each group of pseudorange error samples; c) calculating a weighted sum of the distribution model of each group of pseudorange errors, to obtain an overall pseudorange error distribution model; d) projecting the pseudorange errors to position domain errors; e) calculating a probability that a position domain error is greater than an alarm limit, to obtain an integrity risk probability value; and f) evaluating GBAS integrity performance. The method improves the calculation accuracy of the integrity risk probability value and enhances the effectiveness of integrity evaluation.
US10473783B2
An object is to provide a laser processing device and a laser processing system capable of measuring a distance between a work and a processing head accurately and simply and capable of checking the quality of processing in real time during the processing. Provided are: a photodetector that detects the intensity of a processing laser beam split by optical path splitting means, and outputs a detection signal having a signal intensity responsive to the detected intensity together with a time of detection of the intensity; a signal intensity comparing unit that compares the signal intensities of multiple detection signals received from the photodetector; and a detection time comparing unit that compares times of detection of multiple intensities. The signal intensity comparing unit measures a processing quality by comparing the signal intensity of a detection signal received from the photodetector responsive to an incident beam on a work and the signal intensity of a detection signal received from the photodetector responsive to a reflected beam from the work. The detection time comparing unit measures a distance between a laser processing device and the work by comparing times of detection of the intensities.
US10473782B2
A photoelectric conversion element includes a first photoelectric conversion unit configured to generate an electron serving as a signal charge, a second photoelectric conversion unit configured to generate a hole serving as a signal charge, a first floating diffusion region to which the electron generated in the first photoelectric conversion unit is transferred, a second floating diffusion region to which the hole generated in the second photoelectric conversion unit is transferred, an amplifying transistor including a gate electrically connected to the first floating diffusion region and the second floating diffusion region, a first charge ejection unit configured to eject the electron generated in the first photoelectric conversion unit, and a second charge ejection unit configured to eject the hole generated in the second photoelectric conversion unit, wherein the first photoelectric conversion unit and the second photoelectric conversion unit are arranged along a principal surface of a semiconductor substrate.
US10473780B1
In an example method, a vehicle configured to operate in an autonomous mode could have a radar system used to aid in vehicle guidance. The method could include a plurality of antennas configured to transmit and receive electromagnetic signals. The method may also include a one or more sensors configured to measure a movement of the vehicle. A portion of the method may be performed by a processor configured to: i) determine adjustments based on the movement of the vehicle; ii) calculate distance and direction information for received electromagnetic signals; and iii) recover distance and direction information for received electromagnetic signals with the adjustments applied. The processor may be further configured to adjust the movement of the autonomous vehicle based on the distance and direction information with adjustments applied.
US10473776B2
An antenna including: an array of individually-controllable elementary cells, each cell being capable of transmitting a radio signal by introducing into the signal a controllable phase shift selected from among at least two discrete phase-shift values; on the side of a first surface of the array, first, second, third, and fourth primary sources capable of respectively irradiating first, second, third, and fourth consecutive quadrants of the array; and a processing circuit capable of supplying a first signal representative of the sum of the signals S1, S2, S3, and S4 supplied, respectively, by the first, second, third, and fourth sources, a second output signal representative of difference S1+S2−S3−S4, and a third output signal representative of difference S1−S2−S3+S4.
US10473772B2
A system, comprising a processor; and a memory, the memory storing instructions executable by the processor to receive image data from a vehicle sensor installed in a vehicle, transform the image data into global coordinate data, estimate fractal dimension values of the global coordinate data, and determine calibrated parameters based on the fractal dimension values to operate the vehicle sensor.
US10473770B1
In some embodiments, a method for operating a light detection and ranging (LiDAR) system in an automobile provides a more accurate range estimate by combining multiple processed waveforms which are weighted according to their signal to noise ratios. At least one waveform is transmitted within a first time period, and reflected of an object. The reflected waveform is received and processed to improve the signal to noise ratio (SNR). The processing produces a higher number of output waveforms, such as through processing convolution. The SNR for each of the output waveforms is determined. An estimated range to the object from each output waveform is determined. The estimated ranges are then weighted according to their SNRs, and combined to provide an final determined range to the object.
US10473765B2
A photoelectric sensor includes a lens mounted to a light projecting element at a position that opposes a light projecting lens and configured such that the curvature in the direction perpendicular to a straight line passing through the center of the light projecting lens and the center of the light receiving lens is greater than the curvature in the direction parallel to the straight line passing through the center of the light projecting lens and the center of the light receiving lens.
US10473758B2
Devices and methods of providing response pulses in response to threat pulses are general described. The threat pulses are detected, identified and validity determined using reprogrammable firmware. Threat pulses are extracted from memory and the amplitude, frequency, phase, length and timing modified to generate a coherent set of superposed response pulses in response to the threat pulses. The modifications are calculated in situ using parameterization, rather than being based on tables. Multiple response pulses in response to different threat pulses are simultaneously generated, combined and transmitted in a single channel. Partial pulse capability and the capability to create a weighted and modulated composition of multiple response pulses is provided.
US10473757B2
This disclosure is directed to techniques for an FMCW radar system to determine an unambiguous radial velocity of a target. The radar system measures the Doppler shift in the received return signal reflected from the target, while the radar system simultaneously performs normal surveillance functions. Such a radar system may digitize the beat frequency that results from mixing the received return signal from a target the transmitted signal for a given frequency ramp. The radar system may divide the usable digitized samples at the output of an analog-to-digital converter (ADC) into a number of subsets and analyze the frequencies in each subset. Because each subset of samples covers a time interval that may be substantially less than the period of each frequency ramp, the radar system may extract without ambiguity the Doppler velocity of a target within as little as the period of single frequency ramp.
US10473756B2
A sensor includes a transmit antenna, a receive antenna, circuitry, and a memory. The transmit antenna includes N transmit antenna elements each transmitting a transmit signal. The receive antenna includes M receive antenna elements each receiving N receive signals including reflection signals reflected by an organism. The circuitry extracts a second matrix corresponding to a predetermined frequency range from an N×M first matrix representing propagation characteristics between each transmit antenna element and each receive antenna element calculated from the receive signals. The circuitry estimates the position of the organism by using the second matrix, and calculates a radar cross-section value with respect to the organism, based on the estimated position and the positions of the transmit antenna and the receive antenna. The circuitry then estimates the posture of the organism by using the calculated radar cross-section value and information indicating associations between radar cross-section values and postures of the organism.
US10473751B2
A controller of a collaboration endpoint generates a primary audio signal for an ultrasonic source audio signal produced by a source audio speaker, a reference audio signal for the ultrasonic source audio signal, and, based on the reference audio signal, a predicted signal that is predictive of the primary audio signal. The controller produces a prediction error of the predicted signal by comparing the primary audio signal with the predicted signal and determines whether the prediction error is indicative of a motion of one or more persons near the collaboration endpoint.
US10473747B2
A method for operating a transmit-receive point (TRP) includes generating a different spatial domain to time domain transform (STT) symbol for each antenna element in an antenna array, and transmitting the STT symbols using the antenna array to sweep a beam along a first plane in the time domain.
US10473742B2
A magnetic resonance imaging apparatus includes a radio frequency (RF) controller configured to, during a repetition time (TR) period among TR periods, apply at least one RF pulse corresponding to a first slice to an object, and apply a navigator RF pulse corresponding to a second slice adjacent to the first slice to the object, a data obtainer configured to, during the TR period, obtain first k-space data corresponding to the applied at least one RF pulse, and obtain second k-space data corresponding to the applied navigator RF pulse, and an image processor configured to generate navigator images, based on pieces of second k-space data that are obtained during the TR periods, the pieces comprising the second k-space obtained during the TR period, correct the first k-space data, based on the navigator images, and generate a magnetic resonance image of the first slice, based on the corrected first k-space data.
US10473741B2
A method to generate an attenuation correction map to compensate imaging errors in emission tomography resulting from the presence of hardware parts inside the imaging volume of an emission tomograph. Components of 3-dimensional CAD models of the hardware parts to be compensated are converted into voxels on a predetermined grid and assigned a filling factor per voxel. Image data sets of each component are multiplied with respective attenuation coefficients and thereafter superimposed to form an attenuation correction map. Thereby, in a simple and automatable way a profoundly exact, mostly noise-free and exactly reproducible attenuation correction map for attenuation correction in an emission tomography device may be generated.
US10473733B2
Magnetic field compensation device having a first bar-shaped flux concentrator and a second bar-shaped flux concentrator, wherein the first flux concentrator and the second flux concentrator are separated from one another in a y-direction, and the longitudinal axis of the first flux concentrator and the longitudinal axis of the second flux concentrator are arranged to be substantially parallel to one another. A control unit is in an operative electrical connection with the magnetic field sensor and the compensating coil, and the control unit is equipped to control the compensating current through the compensating coil using a measured signal from the magnetic field sensor in such a manner that, for an external magnetic field formed in the x-direction at the location of the magnetic field sensor, the magnetic field is substantially compensated.
US10473731B2
A reading circuit for a magnetic-field sensor, provided with a detection structure generating an electrical detection signal as a function of an external magnetic field, has a signal-conditioning stage, which is electrically coupled to the detection structure and generates an output signal as a function of the electrical detection signal; the reading circuit is provided with a full-scale-control stage that is able to select automatically a full-scale value for the signal-conditioning stage, as a function of the value of the external magnetic field, such as to prevent saturation of the same conditioning stage.
US10473727B2
Early power failure (EPF) detection circuit applies a rectified, unfiltered periodic waveform, at the frequency of the mains supply voltage to a threshold detector. During each cycle of the periodic waveform, the threshold detector produces a pulse voltage having a leading edge when the periodic waveform begins to exceed a threshold level associated with the threshold detector and a trailing edge when the periodic waveform ceases to exceed the threshold voltage. A microprocessor measures the length of the interval between the leading and trailing edges for indirectly measuring the magnitude (for example, RMS or peak) of the mains supply voltage. When the indirectly measured magnitude decreases below a minimum permissible, second threshold magnitude, a controlled power shutdown of the apparatus is initiated, such as by, for example, programs interrupt routine in the microprocessor.
US10473726B2
A battery management method includes verifying variance information of a physical quantity of each of a plurality of batteries, and identifying a target battery among the batteries based on the variance information. The battery management method also includes determining pack state information of a battery pack comprising the batteries based on state information of the target battery.
US10473725B2
A method for calculating a leakage current of a precipitate by using a voltage drop amount result measured in an aging process according to a discharge voltage of a normal cell and a profile according to a discharge voltage of a normal cell and directly presenting a low voltage expression level based thereon.
US10473719B2
A measurement instrument configured to perform an associated method separates two signals which are present on the same signal line at the same time (e.g., an incident signal and a reflected signal) so that it can measure each signal by itself. In an example, the method may include: receiving a first probed waveform from a first location on a signal line between a source device and a destination device while an output of the source device sends an incident signal to an input of the destination device via the signal line; receiving a second probed waveform from a second location on the signal line, while the output of the source device sends the incident signal to the input of the destination device via the signal line; and ascertaining from the first probed waveform and the second probed waveform the reflection coefficient at the input of the destination device.
US10473713B2
An interposer block, a chip package assembly test system and method for testing a chip package assembly are described herein. In one example, an interposer block for an integrated circuit chip package test system is provided. The interposer block includes a main body, a retainer plate, and a cover plate. A plurality of spring pins are each disposed in a respective one of a plurality of spring pin receiving holes formed in the main body. The retainer plate is coupled to the main body and captures the spring pins within the plurality of spring pin receiving holes. The cover plate is movably coupled to the main body. The cover plate has a plurality of spring pin clearance holes form therethrough that align with the plurality of spring pin receiving holes formed in the main body. A spring bias the cover plate away from the main body to a position where the spring pins not an exposed through a top surface the cover plate, and where the cover plate is movable towards the main body to a position that exposes the spring pins through the top surface of the cover plate.
US10473703B2
This invention relates to an apparatus, a method and a computer program for calculating one or more scattering parameters of a linear network, the network including a number of N ports adapted to provide electric connections. The apparatus is configured to calculate, and the method includes calculating, one or more scattering parameters of the linear network, which are related to a reference impedance, on the basis of a measured electrical response at one or more ports of the linear network to an incident wave applied at a port of the linear network, measured under the condition that one or more of other ports of the linear network face a reflection coefficient Γ with an amplitude ρ of 0.5 or larger. The computer program is adapted to perform such a method and runs on a computer.
US10473695B2
Provided is a current detection device in which, to a bus bar type shunt resistor, another member can be easily connected and fixed by means of rotational fastening of screw members. The current detection device is provided with: a pair of wiring members (11, 12) consisting of electrically conductive metal material; a resistor body (13) consisting of metal material having a smaller temperature coefficient of resistance than the wiring members and which is bonded to the wiring members; and a screw member (16) which is fixed to at least one of the wiring members and which is a separate member from the wiring members. One screw member (16) is fixed to one surface of the wiring members (11, 12), and another screw member (17) is rotationally fastened to the one screw member (16) sandwiching another member (18, 19) disposed on the other surface of the wiring members (11,12).
US10473694B2
A system for atomic force microscopy in which a sharp electrode tip of an flexing probe cantilever is positioned closely adjacent a sample being probed for its electrical characteristics. An optical beam irradiates a portion of the sample surrounding the probe tips and is modulated at a radio or lower modulation frequency. In one embodiment, a reference microwave signal is incident to the electrode tip. Microwave circuitry receives a microwave signal from the probe tip, which may be the reflection of the incident signal. Electronic circuitry processes the received signal with reference to the modulation frequency to produce one or more demodulated signals indicative of the electronic or atomic properties of the sample. Alternatively, the optical beam is pulsed and the demodulated signal is analyzed for its temporal characteristics. The beam may non-linearly produce the microwave signal. Two source lasers may have optical frequencies differing by the microwave frequency.
US10473687B1
A microelectromechanical systems (MEMS) accelerometer that has high sensitivity to motion along the z axis is discussed. The device includes two symmetrical sets of bilateral, diametrically opposed high aspect ratio flexures that tether a movable proof mass to the frame of the device. The flexures are designed in such a way as to restrict movement of the proof mass along the x and y axes but readily allow motion along the z axis. More specifically, when the device experiences an acceleration along the x or y axes, the proof mass is restricted from moving because some of the bilateral, diametrically opposed flexures are in compression and others are in tension.
US10473686B2
An inertia measurement module and three-axis accelerometer, comprising a first pole piece (4) located on a substrate and a mass block (1) suspendingly connected above the substrate via elastic beams (11, 12); the elastic beams (11, 12) includes a first elastic beam (12) and a second elastic beam (11), two ends of the second elastic beams (11) being connected to an anchor point (6) of the substrate, two ends of the first elastic beam (11) being connected to the mass block (1); a center of the first elastic beam (12) and/or the second elastic beam (11) deviates from a center of gravity of the mass block (1); the mass block (1) is further provided with a first movable electrode (9) and a second movable electrode (10) in a Y-axis and an X-axis direction; the movement of one axis in a plane of the inertia measurement module cannot be affected by an eccentric structure feature, such that both X-axis movement and Y-axis movement are linear movements, thus not intensifying an inter-axis coupling, and also not reducing displacement of a mass block on the X-axis and the Y-axis, thus improving capacitance detection precision.
US10473684B2
An approach is provided for determining movement information for at least one user device based, at least in part, on air pressure sensor data. The approach involves determining reference air pressure data associated with a reference set of devices. The approach also involves processing and/or facilitating a processing of the reference air pressure data to cause, at least in part, a classification of the reference air pressure data into one or more candidate movement status categories. The approach further involves determining air pressure sensor data associated with at least one user device. The approach also involves determining at least one movement status category for the at least one user device from among the one or more candidate movement status categories based, at least in part, on the classification.
US10473678B2
Wireless transmission of wheel rotation direction is disclosed. A disclosed apparatus includes a tone ring exhibiting a rotational asymmetry and a detector to measure a rotational direction of a wheel of a vehicle based on the rotational asymmetry and to measure a rotational speed of the wheel, where the detector or the tone ring is operatively coupled to the wheel. The disclosed apparatus also includes a wireless transmitter to transmit the rotational direction and the rotational speed to a receiver proximate or within an engine compartment of the vehicle.
US10473669B2
Methods of treating a subject with IBD with an anti-SMAD7 therapy, such as a SMAD7 antisense oligonucleotide, to reduce CRP levels are disclosed. Methods of treating and managing IBD in a subject using an anti-SMAD7 therapy, such as a SMAD7 antisense oligonucleotide, based on CRP levels are also disclosed. Also disclosed are methods of determining whether a subject with IBD is responsive or likely to be responsive to treatment an anti-SMAD7 therapy. Reduction of CRP levels may correlated with IBD remission or decreases in CDAI score. The present invention also relates to treatment of IBD using an anti-SMAD7 therapy (e.g., an antisense oligonucleotide) in combination with an additional agent. The invention also features related pharmaceutical compositions and kits.
US10473667B2
Embodiments herein provide methods, apparatuses, and systems for detecting, monitoring, measuring, and/or characterizing the activity of phosphoproteins such as tyrosine kinases (TKs) and downstream proteins in TK signal transduction pathways (e.g., TK pathway proteins). In various embodiments, the methods, apparatuses, and systems may use nanoparticles, such as quantum dots (QD), to detect and/or characterize the abnormally overactive TK signaling pathways that underlie tumorgenesis and tumor progression. In various embodiments, the QD-based methods, apparatuses, and systems may have a sufficiently high degree of sensitivity to enable the identification of new TK signaling pathway markers, for example for use in diagnosing, staging, monitoring, and/or prognosing cancers, or in evaluating the efficacy of cancer therapeutics.
US10473666B2
The present invention relates to dye compounds represented by Formulae I and II, which are described in the specification. The dye compounds of the present invention have markedly improved quantum yields and emit strong fluorescence compared to existing cyanine dyes. Due to these advantages, the dye compounds of the present invention can find applications in various fields, for example, as probes for various biological systems where optical imaging is required. Particularly, the dye compounds of the present invention can be used as mitotrackers capable of labeling and tracking mitochondria. Therefore, the dye compounds of the present invention can be used to quantitatively image mitochondria in live tissues and cells. Furthermore, the dye compounds of the present invention can be applied as pH probes for measuring the pH of live cells.
US10473655B2
Test devices are provided for determining the presence of a first ligand in a sample. In some embodiments depletion conjugates are used to deplete the ligands different from but related to the first ligands from the sample. In some embodiments, interim binding agents are used to enhance the test signal.
US10473648B2
Provided is a biosensor including a capillary unit having a capillary channel therein and a reagent disposed in the capillary channel, the reagent being configured to develop colors in a sample, and a measuring unit configured to measure a degree of color development of the sample in the capillary channel.
US10473647B1
Provided herein are compositions and methods for treating autoimmune diabetes such as type 1 diabetes (T1D), diagnosing autoimmune diabetes such as T1D, assessing treatment efficacy, and selecting subjects for treatment, e.g., using a peptide or epitope disclosed.
US10473644B2
A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.
US10473643B2
This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as potential therapeutically effective drugs by simplifying the pharmaceutical discovery and creation process through improvements in hit identification, lead optimization, biological profiling, and rapid elimination of toxic compounds. Implementation results in overall cost reductions in the drug discovery process resulting from the corresponding increases in efficiency.
US10473640B2
The present invention provides methods for selecting a suitable anticancer therapy, and for identifying and predicting response for the treatment of a gastric cancer.
US10473632B2
A sample injector configured to introduce a sample fluid into a mobile phase, wherein the mobile phase is to be driven by a mobile phase drive through a separation unit for separating compounds of the sample fluid in the mobile phase, wherein the sample injector comprises a metering device being operable for displacing fluid and for intaking a metered amount of the sample fluid into the sample injector, an injector valve being switchable for operating the sample injector selectively in a sample intake mode in which the metering device is operable to intake the sample fluid from a sample container, or a separation mode in which intaken sample fluid is driven between the mobile phase drive and the separation unit for separating the compounds, and a flow direction controller configured for defining an enabled flow direction of fluid displaced by the metering device and for defining a disabled flow direction.
US10473630B2
A preprocessing kit includes a separation device, a collecting container, and a skirt part. The skirt part is integrated with the separation device, and is provided to surround an outer circumferential surface of the separation device with a clearance being left from the outer circumferential surface so that a space having a closed upper side and an open lower side is formed between the outer circumferential surface of the separation device and the skirt part. The skirt part is provided in such a way that a lower end of the skirt part comes into intimate contact with a peripheral surface of an opening of the recess part when the collecting container containing the lower end of the separation device is fitted into the recess part.
US10473618B2
A residual chlorine measuring apparatus includes: a detection electrode that is immersed in a sample solution, the detection electrode being made of gold or platinum; a counter electrode that is immersed in the sample solution, the counter electrode being made of silver/silver chloride; a voltage applying device that applies an applied voltage between the detection electrode and the counter electrode; an ammeter that measures an oxidation-reduction current flowing between the detection electrode and the counter electrode; and an arithmetic controller that controls the voltage applying device and acquires the oxidation-reduction current measured by the ammeter.
US10473617B2
A multi-gas detection apparatus is configured such that electric power supplied from a power supply to a heater is controlled by pulse width modulation so as to control the temperature of a first solid electrolyte body. The multi-gas detection apparatus detects the concentration of ammonia by using a first ammonia detection section in which an electromotive force is generated between a first reference electrode and a first detection electrode in accordance with the concentration of ammonia in the exhaust gas. The multi-gas detection apparatus calculates the amount of a change (i.e., offset voltage) in the ammonia electromotive force caused by change in the output voltage of the power supply. The multi-gas detection apparatus corrects the ammonia electromotive force generated in the first ammonia detection section through use of the calculated change amount.
US10473615B2
Provided is a method of manufacturing a porous protective layer for a gas sensor. The porous protective layer according to one Example of the present invention is manufactured by a method of manufacturing a porous protective layer for a gas sensor including (1) a step of introducing a composition for forming a porous protective layer including a pore former and a ceramic powder, which includes particles having a degree of deformation of 1.5 or more expressed by the following Relational Formula 1 according to the present invention, onto a sensing electrode for a gas sensor, and (2) a step of sintering the introduced composition for forming a porous protective layer.
US10473608B2
A liquid sample measuring system includes a measuring device including a measuring section which measures biological information from liquid sample of a living subject within a housing in which a biosensor, on which the liquid sample of the biological body is deposited, is detachably mounted and a movement measuring section which measures movement information of the housing within the housing, and an administrating device including a movement determining section which determines whether or not a degree of the movement of the housing is within an allowable range by analyzing the movement information received from the measuring device.
US10473600B2
Various embodiments include a method for generating a pulse for use in nuclear magnetic resonance (NMR) logging. One such method generates the pulse by adjusting one or more of pulse parameters including a pulse shape, a pulse amplitude, a pulse phase, and/or a pulse frequency. The generated pulse produces a substantially uniform nuclear spin saturation or nuclear spin inversion response from a fluid. A wait time between the pulse transmission and an echo that indicates spin equilibrium has been achieved is substantially equal to a T1 time indicating characteristics of the fluid.
US10473592B2
Methods of determining and characterizing photosynthesis in plant parts of one or more plants includes capturing a plurality of images of the plant parts of the one or more plants with a sensor are provided. Fluorescence of the plant parts of the one or more plants can be measured by storing a sensor image of observed fluorescence. Light absorbed by the plant parts of the one or more plants can be estimated by observing red and/or infrared reflectance of the plant parts. A characteristic of photosynthesis such as linear electron flow in plant parts of the one or more plants can be derived using the measured fluorescence of the plant parts, the reflectance and the light absorbed by the plant parts, and/or the three-dimensional model comprising the plant parts of the one or more plants. Related apparatus and systems are also provided.
US10473584B2
Diffuse reflectance spectroscopy apparatus for use in analyzing a sample comprising a sample receiving location 2 for receiving a sample 3 for analysis; an illumination arrangement 4 for directing light towards a received sample; a detector 6 for detecting light reflected by a received sample; and collection optics 5 for directing light reflected by a received sample towards the detector. The illumination arrangement further comprises an interferometer 42 and a half beam block 45a, 45b which is disposed substantially at a focus in the optical path for blocking light which exits the interferometer, passes said focus, and is reflected from re-entering the interferometer. A half beam block 45a may be disposed in the optical path between the interferometer and the light source 41 for blocking light that exits the interferometer back towards the light source and is reflected by the light source from re-entering the interferometer and/or a half beam block 45b may be disposed in the optical path on the opposite side of the interferometer than the light source.
US10473581B2
A light source, calibration device and method of calibrating an imaging device is disclose. The calibration device includes the light source which includes an ultraviolet light layer that, in operation, generates ultraviolet light, and a quantum dot layer that absorbs the ultraviolet light and, in response, generates radiation within the near infrared region at a selected intensity. The near infrared light is received at the selected intensity at the imaging device and a sensitivity of the imaging device is altered to detect the near infrared light at the selected intensity provided by the light source.
US10473576B2
A system for analyzing a transparent particle including: an analysis pathway, including a first light source emitting an analysis light beam, and a first optical system focusing the analysis light beam in a focusing plane; and a position control pathway including a second light source, an image sensor, and a second optical system at least partially merged with the first optical system. The image sensor is offset relative to the image of the focusing plane by the second optical system. The system makes it possible to control correct positioning of the particle, even though it is transparent, and without disturbing the analysis pathway.
US10473574B2
There is provided an assembly and process for its preparation for predicting the permeability of chemical compounds, comprising a donor compartment for adding a composition comprising the compound; a barrier based on a support and a phospholipid layer adhering to the support; and an acceptor compartment for accepting the compound upon permeation of the barrier.
US10473558B2
An metallographic system comprising a programmable controller, a robotic arm, a specimen clamping or holding device, a sectioning saw, a mounting station, a polishing station, a specimen preparation station, and an analyzer for examining the specimen.
US10473557B2
A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.
US10473545B2
The present invention relates to an apparatus for controlling, measuring and reporting a physical quantity, more specifically to an apparatus that can be adapted to any valve of a container containing a fluid under pressure, more particularly a device that can be adapted to any valve of a container containing a gas or liquid under pressure. It has a particularly advantageous application in the general field of measuring the pressure of the output flow of fluid, in particular industrial or medicinal fluids contained in bottles. The machine comprises the support, electromechanical switch constituted by the dosing knob and the support for the dosing knob which incorporates the electronic circuitry for controlling the rate of fluid flow by pressure sensor for reading the output pressure of the fluid from the container and by the data processing system for processing the data obtained by the electromechanical switch and by the pressure sensor. This information can be viewed on the display or remotely transmitted.
US10473543B2
A method of making and confirming a fluid connection involves making a fluid connection including, at a female piece side, a female piece, and at a male piece side, a male piece axially inserted into the female piece and a shoulder opposing the female piece. By the fitment of a socket portion of an end attachment over the female piece, a bifurcated claw of the socket portion engages between the female piece and the shoulder. Via the bifurcated claw, a disconnection force is applied between the female piece side and the male piece side by pivoting a torque wrench supporting the end attachment.
US10473541B2
A device and system for detecting dynamic strain. The device comprises a longitudinally extending carrier and an optical fiber embedded along an outer surface of a length of the carrier. The optical fiber comprises at least one pair of fiber Bragg gratings (FBGs) tuned to reflect substantially identical wavelengths. The system comprises the device and an interrogator comprising a laser source and a photodetector. The interrogator is configured to perform interferometry by shining laser light along the optical fiber and detecting light reflected by the FBGs. The interrogator outputs dynamic strain measurements based on interferometry performed on the reflected light.
US10473540B2
A gas strut monitoring system includes a gas strut. The monitoring system further includes a knuckle assembly connected to a base end of the gas strut. The knuckle assembly includes at least one strain gauge and a deformable knuckle. The system also includes a controller in communication with the at least one strain gauge, which is configured to measure a deformation of the deformable knuckle via the strain gauge. The system evaluates, based on the measured deformation, an operative performance of the gas strut. The system then outputs signal to an output device that indicates a maintenance recommendation based on the operative performance of the gas strut.
US10473531B2
A temperature sensor includes a plurality of temperature coefficient voltage generators, one or more converters and at least one variable voltage or current source. The temperature coefficient voltage generators are used for generating multiple temperature coefficient voltages. The converters, coupled to the temperature coefficient voltage generators, are used for converting the temperature coefficient voltages to digital values. The at least one variable voltage or current source, each coupled to at least one of the temperature coefficient voltage generators, includes a first variable voltage or current source for outputting a first voltage or current in a first time period, and outputting a second voltage or current in a second time period, wherein the second voltage or current is different from the first voltage or current such that there exists a shift between a first voltage-temperature curve in the first time period and a second voltage-temperature curve in the second time period.
US10473529B2
The disclosed device is a hand-held probe thermometer which operates to display temperatures sensed by a temperature sensing probe, and a protective probe cover featuring one or more openings to allow for accurate airflow temperature measurements without removing the protective probe cover. The probe cover is also configured to function as a extendable handle for the duct thermometer to allow for an extended reach when taking measurements.
US10473526B2
The invention pertains to a method of spatially resolved detection of a gas substance in an area, comprising: imaging the area on a first image sensor, in a wavelength spectrum including an absorption wavelength peak corresponding to said gas substance; imaging the area on a second image sensor, to provide for each pixel of the first image a corresponding pixel of the second image for respective on- and off-peak wavelengths relative to the absorption wavelength; and providing a difference image as a function of the two pixel values of first and second image sensors to produce an image of the spatially resolved absorption wavelength corresponding to said gas substance.
US10473525B2
Disclosed is a method, system, and apparatus for optical emission measurement. The apparatus includes a collection system for collecting a plasma optical emission spectra through an optical window disposed at a wall of a plasma processing chamber. The optical system includes a mirror configured to scan a plurality of non-coincident rays across the plasma processing chamber; and a telecentric coupler for collecting an optical signal from a plasma and directing the optical signal to a spectrometer for measuring the plasma optical emission spectra.
US10473520B2
A light source device for calibrating an image sensor is provided. The light source device includes a light source unit for outputting light, a transform filter unit for controlling a color temperature according to a wavelength of the light received from the light source unit, and a plurality of diffusion plates for controlling a ratio of long-wavelength light to short-wavelength light, the long-wavelength light and the short-wavelength light being output from the light source unit.
US10473517B2
An acoustic emission source expansion apparatus integrated hydraulic engineering construction behavior fiber sensing device includes a base plate, a first side plate and a second side plate fixedly connected with two sides of the base plate, the top portion of the first side plate is connected with the top portion of the second side plate through an arc-shaped fiber-carrying channel, and a main common cavity is formed by the base plate, the first side plate, the second side plate and the arc-shaped fiber-carrying channel; a pair of sensing fibers is arranged in the arc-shaped fiber-carrying channel, the sensing fibers are tightly pressed in the arc-shaped fiber-carrying channel through a pressing block, the pressing block is provided with a plurality of springs, the springs tightly press the pressing block through a cover plate, and the cover plate is arranged on the first side plate and the second side plate.
US10473511B2
A sensor device configured to be attached to a drug delivery device and configured to illuminate the drug delivery device when attached, the sensor device comprising: a light guide having a first surface, a second surface opposed to the first surface, at least one side surface extending between the first and second surfaces and a light out-coupling structure configured to cause diffuse light to be emitted from the first surface when light is input into the light guide; at least one light source configured to in-couple light into the light guide; and an optical sensor arranged to receive light reflected from a surface of the drug delivery device.
US10473508B2
A device that measures fluid level in fuel storage tanks of mining trucks resistant to rapid filling includes an externally mounted sensor, a protective metallic tube, an anchorage system, and a pressure dissipator; and a remote monitor system that controls fluid level in fuel storage tanks of mining trucks includes a device that measures fluid level in fuel storage tanks of mining trucks including an externally mounted sensor, a protective metallic tube, an anchorage system and pressure dissipator, antennas, a Web server, remote means, and a power source.
US10473506B1
The present invention relates to oil level visualization system that is used in place of a conventional dipstick to measure oil level. The system may include a strip that has a tube attached thereto comprising an oil absorbent material. Oil from the oil reservoir is configured to absorb to the oil absorbent material and absorbing of the oil to the oil absorbent material is configured to provide a stain on the oil absorbent material visible to the naked eye. The present invention also relates to methods of using the same.
US10473504B2
A server system for remote monitoring includes a wireless communication interface, a processor, and a storage device. The wireless communication interface receives at least one data packet over wireless communications from a remote monitoring system. The processor processes the data packet including sensor information from a sensor coupled to the remote monitoring system. The storage device stores the sensor information.
US10473493B2
An oscillator-based sensor interface circuit comprises at least two oscillators, at least one of which is arranged for receiving an electrical signal representative of an electrical quantity being a converted physical quantity, phase detection means arranged to compare output signals of the at least two oscillators and for outputting a digital phase detection output signal in accordance with the outcome of the comparing, a feedback element arranged for converting a representation of the digital phase detection output signal into a feedback signal used directly or indirectly to maintain a given relation between oscillator frequencies of the at least two oscillators, detection means for detecting a difference between the at least two oscillators; and at least one tuning element arranged for receiving the detected difference and for tuning at least one characteristic of the oscillator-based sensor interface circuit.
US10473488B2
A magnetic measurement target is configured to be positioned inside a vehicle axle and to cooperate with at least two magnetic movement sensors to measure deformation of the axle. The magnetic measurement target includes a body with a fastener end for fastening to one end of the axle and a main portion. The main portion includes a slot formed in an axial direction to separate two longitudinal portions of the body. Each longitudinal portion of the body presents a target surface for which movement can be measured by a magnetic movement sensor.
US10473486B2
In one aspect, an integrated circuit (IC) includes a magnetic field sensor to detect speed and direction of angular rotation of a rotating magnetic structure. The magnetic field sensor includes at least two magnetic field sensing elements configured to sense changes in a magnetic field caused by rotation of the magnetic structure. The IC also includes an output port configured to provide an output signal of the magnetic field sensor. A duty cycle percentage of the output signal indicates the speed and the direction or indicates a fault.
US10473468B1
A system described herein may generate visual representations of physical locations, such as floors of office buildings, outdoor areas, or other types of places. The visual representations may be based on a node map, which may be generated based on data received from user devices and/or by owners or proprietors of business or other types of locations. The node map, for a given place, may indicate features of the place, such as architectural features (e.g., doors, walls, or rooms), visible features (e.g., wall hangings, signs, or other landmarks), Radio Frequency (“RF”) footprint features, or other features. The node map may indicate the likelihood of a given user device moving from one node to another node, and these likelihoods may be used to generate navigation instructions.
US10473467B2
A method for determining which level a vehicle is at when the vehicle is on a multi-level road system is to be implemented by a vehicle auxiliary system that includes a vehicle equipment unit and a server unit. The method includes the steps of: obtaining visual media data of surroundings of the vehicle generated by an image capturing module of the vehicle equipment unit; receiving reference data associated with surroundings of a vehicle in the multi-level road system from the server unit; and generating a recognition result indicating at which level the vehicle is by performing an image-matching technique on the visual media data and the reference data.
US10473463B2
In a technology for detecting the water level of a river by image processing, after an angle of view setting process, an area setting unit sets an arbitrarily defined certain range from the center of the set angle of view as a processing area. Then, a flow processing unit calculates, from the processing area, motion information and a flow direction, computes a flow density, determines a region having a high density and similar flow directions to be a flow of water currents, and deletes flows in the other directions. Thereafter, a graph-cut processing unit creates an object seed and a background seed for graph-cutting, and detects a water surface by automatic graph-cutting. After an edge extraction processing unit has performed edge extraction, a water level calculation processing unit determines an edge that satisfies a predetermined condition to be a water level line, and outputs a water level measurement result.
US10473459B2
A waveguide apparatus includes a planar waveguide and at least one optical diffraction element (DOE) that provides a plurality of optical paths between an exterior and interior of the planar waveguide. A phase profile of the DOE may combine a linear diffraction grating with a circular lens, to shape a wave front and produce beams with desired focus. Waveguide apparatus may be assembled to create multiple focal planes. The DOE may have a low diffraction efficiency, and planar waveguides may be transparent when viewed normally, allowing passage of light from an ambient environment (e.g., real world) useful in AR systems. Light may be returned for temporally sequentially passes through the planar waveguide. The DOE(s) may be fixed or may have dynamically adjustable characteristics. An optical coupler system may couple images to the waveguide apparatus from a projector, for instance a biaxially scanning cantilevered optical fiber tip.
US10473449B2
A single-chip off-axis magnetoresistive Z-X angle sensor and measuring instrument. The single-chip off-axis magnetoresistive Z-X angle sensor comprises a substrate located on an X-Y plane, at least one X-axis magnetoresistive sensor and at least one Z-axis magnetoresistive sensor, the X-axis magnetoresistive sensor and the Z-axis magnetoresistive sensor being located on the substrate. The X-axis magnetoresistive sensor and the Z-axis magnetoresistive sensor each comprise magnetoresistive sensing units and a flux concentrator, the magnetoresistive sensing units being electrically connected into a magnetoresistive bridge comprising at least two bridge arms. The Z-axis magnetoresistive sensor is a push-pull bridge structure, a push arm and a pull arm of the push-pull bridge structure being respectively located at positions equidistant from a Y-axis central line of the flux concentrator. The X-axis magnetoresistive sensor is a reference bridge structure, a reference arm and a sensitive arm of the reference bridge structure being respectively located on the Y-axis central line of the flux concentrator and a position more than half of the width of the flux concentrator away from the Y-axis central line. The single-chip off-axis magnetoresistive Z-X angle sensor is placed at an edge of a circular permanent magnet encoding disc and forms an angle measuring instrument. Angle measurement is achieved by measuring X-axis and Z-axis magnetic field components, the structure is compact and sensitivity is high.
US10473448B2
A device is configured to determine a relative deflection of two transmitter elements by a sensor element. The transmitter elements are arranged at the sensor element. The deflection of the transmitter elements with respect to one another at the sensor element can be determined based on a degree of overlap of conductive regions of the transmitter elements by the sensor element.
US10473436B2
A blast resistant barrier system includes a base, a support structure extending outward from the base, a protective barrier that is pivotally coupled with the support structure at a first point of the protective barrier, and a shear pin that is configured to couple a second point of the protective barrier to the support structure so as to constrain rotation of the protective barrier relative to the support structure. The shear pin is configured to shear upon a threshold amount of force being applied to a face of the protective barrier. Once the shear pin shears, the protective barrier is permitted to rotate relative to the support structure about the first point.
US10473431B2
When a shooter aims down the slide of semi auto handgun needs to align the front sight between the two posts of the rear sight. This is the hardest thing for an instructor to correct not being able to see what the student is looking at. This aid will provide a reference point for the shooter to keep the front sight below, this helps promote proper sight acquisition. This is a plastic hood that slides over top of the rear sight and over the slide. The shooter is able to shoot with this aid on the firearm.
US10473428B2
Representative implementations of devices and techniques provide a ankle holster assembly to mount and to support an implement (such as a handgun, for example) or an implement holster (such as a handgun holster, for example), or the like, in a variety of configurations. The ankle holster assembly includes a base having a receiver and a post having a shaft, the shaft arranged to be inserted into the receiver to removably couple the post to the base.
US10473422B2
A Flobert cartridge pistol with a barrel with a chamber, a slide, a receiver containing a hammer, a trigger, a decoupler, and an ammunition magazine in the handle of the pistol is disclosed. The double action trigger causes a Flobert round in the chamber to be fired, and the energy from the discharge of the round causes the slide to move back and the spent shell from the round to be ejected from the pistol, and engages a decoupling mechanism, which prevents the slide from cocking the hammer. The slide returns to its starting position, and the slide-return action strips a new round from the magazine and chambers the round, ready for firing.
US10473415B2
A muzzle brake device includes a main body having a receiver opening, a discharge opening, a central bore, and a plurality of discharge channels extending outward from the central bore at locations between the receiver opening and the discharge opening. A plurality of raised inlet members are disposed along the central bore and are in communication with the plurality of discharge channels. A separation distance between the channels is complementary to the length of the projectile to which the weapon on which the device is attached, and each of the discharge channels are arranged to emulate the vane of a turbine engine, so as to produce a mechanical force that counteracts the recoil of the weapon to which the device is attached.
US10473413B1
A portable descaling apparatus for creating a forceful fluid flow through passages of a heat exchanger may comprise a cart, a fluid tank mounted on the cart and having an interior configured to hold a quantity of fluid, a fluid pump mounted on the cart and being configured to pump fluid from the tank under pressure and a pump motor mounted on the cart and being connected to the fluid pump to operate the pump.
US10473410B2
A boiling heat transfer unit includes a substrate having a heat exchange region including a plurality of nucleating regions adjacent to feeder channels, wherein adjacent nucleating regions are separated by the feeder channels at a distance whereby vapor formed in the nucleating regions is moved away from the nucleating regions influencing liquid flow through the feeder channels towards the nucleating regions thereby establishing continuous self-sustaining separate vapor and liquid pathways increasing heat transfer due to developing region heat transfer in the feeder channels and enhancing overall boiling performance.
US10473398B2
A modular furnace, in particular for the oxidative stabilization of a carbon fiber starting material comprising a cuboidal furnace chamber, on the upper face of which first deflecting rollers are arranged in a mutually spaced and parallel manner and on the lower face of which second deflecting rollers are arranged in a mutually spaced and parallel manner such that the carbon fiber starting material runs upwards and downwards in a laterally adjacent and slightly spaced manner so as to meander vertically in the area of the furnace chamber. A carbon fiber inlet locking device and a carbon fiber outlet locking device are provided on the upper face of the furnace chamber, and an air guiding device is connected to the furnace chamber. A supply air portion of the air guiding device is connected to a vertical air inlet side of the furnace chamber, and a discharge air portion of the air guiding device is fluidically connected to a furnace chamber vertical air outlet side opposite the vertical air inlet side. The air guiding device has an air drive device between the supply air portion and the discharge air portion.
US10473389B2
A refrigeration appliance including both a user interface and door position sensor. The same devices and sensors are for both functions. The user interface is mounted on a door or mullion in such a way that all or nearly all of the input devices on the user interface are activated simultaneously or nearly simultaneously when a door is closed so that the user interface can distinguish this action from user inputs in which only one or two input devices are activated at a time. Likewise, when all input devices are inactivated nearly simultaneously, the user interface may know that a door has been opened.
US10473379B2
A refrigerator includes a heat exchange chamber, first inlets arranged on side surfaces of a first storage chamber and configured to introduce cold air in the first storage chamber into the heat exchange chamber, and second inlets arranged on side surfaces of a second storage chamber and configured to introduce cold air in the second storage chamber into the heat exchange chamber.
US10473375B2
Apparatus for controlling a cryogenic cooling system is described. A supply gas line (3A) and a return gas line (3B) are provided which are coupled to a compressor (1) and to a mechanical refrigerator (2) via a coupling element (4). The coupling element is in gaseous communication with the supply (2A) and return gas lines and supplies gas to the mechanical refrigerator (2). The pressure of the supplied gas is modulated by the coupling element in a cyclical manner. A pressure sensing apparatus (6) monitors the pressure in at least one of the supply and return gas lines. A control system (5) is used to modulate the frequency of the cyclical gas pressure supplied by the coupling element in accordance with the pressure monitored by the pressure sensing apparatus. An associated method of controlling such a system is also described.
US10473373B2
A microchannel heat exchanger has an upper portion connected in fluid communication with a header, a lower portion connected in fluid communication with the header at a location that is vertically lower on the header than the upper portion, and a sight glass on the header. The sight glass can be horizontally aligned with a top of the second portion. The sight glass can be served as a visual aid when charging the microchannel heat exchanger with a refrigerant at a predetermined level. When an indicator indicates that refrigerant is mixed vapor and liquid, refrigerant can be added into the microchannel heat exchanger. When the indicator indicates that the refrigerant is liquid, the charging process can be stopped.
US10473372B2
A method for charging a field refrigeration system including an evaporator, a condenser, a compressor, and an expansion device includes calculating a field subcooling of the field refrigeration system as a function of a measured field liquid line pressure and a measured field liquid line temperature. A charge adjustment percentage can be calculated as a function of the field subcooling, a measured field indoor wet bulb temperature, and a measured field outdoor dry bulb temperature. A refrigerant adjustment weight can be determined based on the charge adjustment percentage. A field refrigeration system charge can be adjusted by the refrigerant adjustment weight.
US10473369B2
A refrigeration system includes a compressor configured to compress a refrigerant, a condenser, and an evaporator. A heat exchanger is disposed downstream of the condenser and upstream of the evaporator, and disposed downstream of the evaporator and upstream of the compressor, the heat exchanger configured to facilitate heat exchange between the refrigerant supplied from the condenser and the refrigerant supplied from the evaporator. A first expansion device is disposed downstream of the heat exchanger and upstream of the evaporator, and a second expansion device is disposed downstream of the condenser and upstream of the heat exchanger. The second expansion device is configured to cool the refrigerant passing therethrough to cool the refrigerant in the heat exchanger supplied from the evaporator to the compressor.
US10473367B2
A heat pump apparatus, including: a two-cylinder compressor including: an electric motor; two compression units to be driven by the electric motor, the two-cylinder compressor being structured to switch between two operation modes including single operation in which one of the compression units is brought into a non-compression state, and parallel operation in which both the compression units are brought into a compression state; an inverter drive control device supplying drive power to the electric motor of the two-cylinder compressor; an operation mode detecting-determining unit determining a current operation mode based on an electric signal acquired from the inverter drive control device; and a capacity control device determining a rotating frequency of the electric motor so that a temperature of a target object is brought close to a set value, to thereby control the inverter drive control device based on a result of determination of the operation mode detecting-determining unit.
US10473364B2
A heat pump system comprises a compressor, a first heat exchanger, a second heat exchanger, a mode switching valve, a throttling element and a reservoir, wherein the throttling element is arranged on a flow path between the first heat exchanger and the second heat exchanger; and which further comprises a mode switching flow path in which a first flow path and a second flow path are arranged, the reservoir is arranged on the second flow path and each flow path is controllably opened or closed to realize different functional modes.
US10473362B2
The invention, in some embodiments, relates to solar energy collectors, and methods of use thereof. In some embodiments, the invention relates to liquid-air transpired solar energy collectors, and methods of use thereof. In some embodiments, the invention relates to thermal energy transfer systems that comprise solar energy collectors, and methods of use thereof. In some embodiments of the invention, methods of constructing solar energy collectors are provided.
US10473359B2
A fan includes: an impeller including a main plate having a first plane, a plurality of first blades each formed the first plane, and a shroud formed integrally with the plurality of first blades; a fan case; a drive source; and a rotation shaft. The first blades each include a linearly protruding region that is linearly increased in height from an outer circumferential side to an inner circumferential side, and a curvedly protruding region that is curvedly increased in height from the outer circumferential side to the inner circumferential side, the height extending in a direction in which each first blade protrudes. The linearly protruding region is welded to the main plate. Accordingly, a highly durable fan can be implemented that allows sufficient durability to be maintained even under a high temperature environment or an acid environment.
US10473356B2
An indoor unit of an air conditioner includes a guide member provided below an air discharge port of a blower fan and upstream of the heat exchanger. The guide member has a guide portion disposed to face an end surface upstream of the heat exchanger, and the guide portion is a plate body whose cross-section has a linear shape parallel to the end surface when cut along a plane including a rotation axis of the blower fan. Thus, provided is the indoor unit of the air conditioner capable of more uniformly guiding air from the blower fan in a height direction of the heat exchanger by the compact and inexpensive guide member.
US10473349B2
A system and method for introducing external air into an enclosure having an exhaust fan for removing internal air at an outflow rate. A sensor measures a quantifiable characteristic which is indicative of the outflow rate. Based on the measured quantifiable characteristic, a controller determines a speed of a makeup air fan that results in the inflow rate matching the outflow rate, and opens a damper and runs the makeup air fan at the determined speed. For example, the sensor may measure an amount of electrical current flowing to the exhaust fan, and low and high speed exhaust fan values are stored in a memory, and corresponding low and high makeup air fan speeds are set. The controller then controls operation of the makeup air fan based on the amount of current flowing to the exhaust fan and the corresponding makeup air fan speed to match the inflow and outflow rates.
US10473335B2
A combined furniture and heating device having a concealable electric fireplace insert installed within a fireplace compartment of a furniture apparatus is provided. The electric fireplace insert has a front surface from which simulated flames are viewable when an opening of the fireplace compartment is uncovered so that the furniture apparatus is configured in its open configuration. The furniture apparatus includes a concealing panel removably installable over the opening configure the device in a concealed configuration so that the electric fireplace insert and its simulated flames viewable at its front surface are at least partially concealed. Power to a heating apparatus of the electric fireplace insert is turned on and off by a disabling device as the concealing panel is alternated between the open and concealed configurations. The disabling device can include a switch or a thermistor.
US10473333B2
The invention proposes a vortex generating arrangement, especially for a pre-mixing burner of a gas turbine, having an air conducting channel of predetermined height extending between two essentially parallel channel walls and having a predetermined direction of air flow, and having a plurality of vortex generators arranged in the channel. An improved mixing is achieved by the vortex generators each having the shape of a triangular plate, which is arranged essentially perpendicular to the channel walls and oriented relative to the direction of air flow with a predetermined off-axis angle ≠0°, and a first side of the triangular plate being oriented perpendicular to the channel walls.
US10473323B2
A loading tube has Japanese cotton placed within a polymer tube. The tube has a hollow, cylindrical form with a tip and an opposite tail. The Japanese cotton advances through the tube exiting at the tip and withdrawing from the tail. The tube has a sidewall with a thickness and an inner diameter suitable for containing Japanese cotton and then advancing it into an atomizer. The outer diameter of the tube cooperates with an aperture in the coil of the atomizer. The tip and the tail have a rim with a square cut. The tube has its size that relates its length to its inner diameter, and to its thickness within a range. The tube utilizes polypropylene for its construction. Alternative fibrous material may be substituted for Japanese cotton.
US10473319B2
A lighting device is provided, comprising at least one LED module, which is connected to a retainer, and a driver that is electrically connected to the LED module, wherein the driver is at least partially cast by a potting material wherein the driver is connected to the retainer via an adaptor board that is positioned in between the driver and the retainer.
US10473318B2
An LED fixture (200) that facilitates effective heat dissipation of an array of LEDs, having improved thermal performance; and is easy to mount or dismount. The LED fixture (200) includes a heat sink (202) having a hollow configuration, and a plurality of fins (204) extending circumferentially and outwardly from the heat sink (202). The LED fixture (200) further comprises a base (206) configured at an operative bottom portion of the heat sink (202), and a driver housing (208) connected to an operative top surface of the heat sink (202). The base (206) is configured to support an array of LEDs. The driver housing (208) is configured to accommodate a plurality of LED drivers. The driver housing (208) and the base (206) are arranged in a spaced apart configuration.
US10473317B2
A vertically disposed HID lamp fixture for growing plants, which includes a housing having an interior, an exterior, a top hole, and a lower lip defining a light opening towards the plants, further including an inlet duct and outlet duct for the forced air cooling embodiment, a socket tower having an upper flange and a lower flange, the upper flange affixed around the perimeter of the top hole securing the socket tower to the housing, a reflector having an aperture, the lower flange affixed around the perimeter of the aperture suspends the reflector within the housing such that an isolation chamber is formed between the exterior side of the reflector and the interior of the housing, a HID lamp removably engages within the socket tower longitudinally extending substantially downward and through the aperture vertically disposed above the light opening sealed by a compressively held glass sheet.
US10473310B2
A lighting assembly can be quickly and efficiently mounted to a crown of a drilling rig derrick in order to provide wide-area illumination of the derrick and surrounding work location. An adjustable support frame member can be operationally attached to a hand rail of a derrick crown using fixed-length bracket members, adjustable-length bracket members and/or a combination(s) thereof. Lighting-emitting light source elements are adjustably attached to the support frame, and can be selectively aimed to direct light as desired.
US10473306B2
In an example embodiment, a lighting fixture comprising a lighting device and a mounting bracket is provided. The lighting device comprises a front cover, a back cover, a frame, and at least one LED mounted within the interior of the lighting device. The frame has an interior edge that is in contact with a perimeter of the front cover and a perimeter of the back cover. The front cover, the back cover, and the frame define the interior of the lighting device. At least one of the frame and the back cover comprises one or more attachment mechanisms. The mounting bracket comprises a junction box mounting element configured for securing the mounting bracket to a junction box or a mounting surface, and one or more attachment mechanism mating elements configured to mate with the one or more attachment mechanisms when the lighting device is rotated within the mounting bracket to secure the lighting device into the mounting bracket.
US10473297B1
A lighting system may include a plurality of suspenders and a beam configured to provide light in at least one direction. The suspenders may structurally support the beam from a ceiling and may provide electrical power and dimming control signals to the beam. The beam may include a plurality of light engines for emitting light. The light engines may be single sided or dual sided, and may transmit electrical power among each other. The dual sided light engines may emit light upwardly and downwardly from the beam, and the single sided light engines may emit light downwardly.
US10473291B2
Disclosed herein is a filament bulb with uniform luminance, which decreases the dark area at the top portion of the filament bulb and increases the luminance efficiency, and includes the following components, a bulb casing, a filament unit, a reflector ring, a driver, and a bulb cap. The bulb casing is connected with the bulb cap, and together, the two define an interior space. The driver is disposed in the bulb cap, whereas the filament unit is disposed within the interior space and the bottom of the filament unit is electrically connected with the driver. The reflector ring surrounds the exterior of the bottom of the filament unit, and is configured to reflect the light emitted from the filament unit to decrease the dark area at the top portion of the filament bulb.
US10473289B2
Embodiments include: a light emitting diode for emitting light; and a lens array including first to fourth lenses sequentially arranged in line in a first direction, wherein the first to fourth lenses are each convex lenses, the first lens and the fourth lens are the same in shape, the second lens and the third lens are the same in shape, the first and second lenses are each arranged in convex configurations in the first direction, the third and fourth lenses are each arranged in convex configurations in the direction opposite to the first direction, and the first direction is a direction oriented toward the first lens from the light emitting diode.
US10473288B2
A daylight portable lamp for inspecting painted surfaces, in particular in the course of paint repair work on motor vehicles, includes at least a head part with a light-exit opening, through which the light that can be produced by the daylight portable lamp can leave, and a sleeve, which surrounds the light-exit opening and is produced from an elastic, preferably rubber-elastic, material, arranged at the light-exit opening.
US10473285B2
A lighting module for a motor vehicle headlight including at least one light source and optical elements for forming at least one light pattern, characterized in that each light pattern is divided into an upper portion and a lower portion which are lit simultaneously and inseparably, the upper portion being delimited transversely by two vertical edges for each of which the light intensity decreases according to a first determined gradient, and the lower portion being delimited transversely by two vertical edges for each of which the light intensity decreases according to a second determined gradient lower than the first determined gradient.
US10473284B2
In described examples of an automotive headlamp, a first illumination source outputs a first color light, and a second illumination source outputs a second color light different from the first color light. A digital micromirror device receives the first color light and the second color light and reflects the first color light and the second color light. A projection optics receives reflected light from the digital micromirror device and outputs a beam from the automotive headlamp having a color that is a combination of the first and second colors. A controller controls intensity and duration of the first illumination source and the second illumination source, controls a pattern on the digital micromirror device, and spectrally tunes the color of the output beam.
US10473277B1
A lighted wire fishing device for installing wire includes a rod that is resilient. The rod is semiflexible so that the rod is configured to be used to fish a wire through a structural element of a structure. A housing is coupled to and extends from a first end of the rod. The housing defines an interior space. A power module is coupled to the housing and is positioned in the interior space. A plurality of bulbs is coupled to the rod and extends from proximate to the first end to proximate to a second end of the rod. The plurality of bulbs is operationally coupled to the power module. The power module is positioned to selectively power the bulbs to illuminate an area proximate to the rod so that the rod and the wire are visible to a user.
US10473273B1
A lamp is provided that includes a housing including a light projecting end and a base having an electrical connector for connection with a lamp fixture; and a light engine including light emitting diodes (LEDs) that is positioned at the light projecting end of the housing. A driver assembly may be in electrical communication with the electrical connector of the base of the housing. In some embodiments, an inductive connection is positioned between the driver assembly and the light engine. The inductive connection may include a transmission coil in the driver assembly, and a receiver coil in the light engine that provides for the transfer of energy magnetically from the driver assembly to the light engine.
US10473272B2
A lighting device comprises a holder for LED filaments. The holder has a first electrically conductive holding structure and a second electrically conductive holding structure. Each holding structure comprises an essentially longitudinal connection section and an attachment section essentially perpendicular to the connection section.
US10473270B2
Leak detection user interfaces are provided. In general, a user interface for a pipeline management system can be configured to provide information regarding one or more pipelines to a user. The information can include data gathered using one or more sensors sensing various parameters. The information on the user interface can include results of analysis of the gathered data, such as notifications that the gathered data indicates an anomaly with a pipeline. The notifications of anomalies can be provided on the user interface in real time with the data analysis. Accordingly, the user can trigger one or more corrective actions such as notifying maintenance personnel local to a location of the identified anomaly, remotely controlling the pipeline with the anomaly to close valve(s) and/or other equipment to prevent fluid flow in the pipeline in the area of the detected anomaly, etc.
US10473268B2
A gas supply apparatus includes; a compressor unit including a compression section compressing hydrogen gas and storing pressure accumulators with the compressed hydrogen gas and a drive portion including an electric motor as drive source and driving the compression section; and a control unit controlling the electric motor. The electric motor has output characteristics where rated torque can be maintained against rotational speed changes in a standard rotation region, rotation region at or below standard speed, and output torque decreases from the rated torque as electric motor rotational speed increases in an overspeed region, rotation region above the standard speed. The control unit performs, in at least part of a storage process where the compression section stores the pressure accumulators with the hydrogen gas until set pressure is reached, overspeed operation control for allowing driving of the electric motor in the overspeed region.
US10473266B2
A high-pressure tank in which a liner can be formed using the conventionally used material, a decrease in the volumetric efficiency within the liner can be suppressed, and influence of a temperature rise due to adiabatic compression on the liner can be significantly alleviated. The tank includes a liner that suppresses permeation of gas; a valve device that allows the inside of the liner and the outside of the tank to communicate with each other and blocks communication therebetween; and an inner container with a through-hole disposed within the liner such that a gap is formed between the inner container and an inner periphery of the liner. The first communication channel of the valve device connects with a pipe extending in the gap and having holes therein. Gas supplied to the valve device is supplied into the gap from the holes in the pipe, and fills the inner container in a high-pressure state from the gap through the through-hole in the inner container.
US10473261B2
Installation of a removable tripod foot is facilitated by a cross-axis aperture in the foot and loosening of the threaded connection of the foot and the tripod's leg is resisted by a resilient element engaging interfacing surfaces of the foot and the leg.
US10473256B2
A pipe lining apparatus having a resin-impregnated reinforcement filament that is helically wound onto the inner surface of a tubular first lining layer disposed within a pipe by an inverted filament winding apparatus, the apparatus having a spring-loaded, articulated frame which maintains an orbiting applicator assembly.
US10473253B2
A bell end adapter arrangement facilitates assembly of conduit sections through which associated electrical wiring and/or cables are routed. The arrangement includes a bell end adapter assembly having an outer bell end adapter, and an inner sleeve portion fixed within the outer adapter. The adapter assembly particularly facilitates routing of wiring from a conduit section positioned within a concrete slab or like flooring element, with the adapter assembly configured to be inserted into the slab and joined to the conduit section disposed within the slab. The adapter assembly has a outwardly flared, bell-shaped open mouth which is configured to receive a second conduit section through which wiring form the first conduit section is routed.
US10473240B2
A hose mounting assembly that includes a mounting member having a base and a main body portion. The main body portion includes first and second ends, a curved tie tunnel defined therethrough, and a curved mounting surface. The base includes a first connection opening defined therethrough.
US10473222B2
A low drag fluid seal. The fluid seal includes a lip separated from the rotor shaft, during operation, by a gap, the gap being sufficient narrow, radially, to prevent liquid from seeping through the gap at an unacceptable rate, but sufficiently wide, radially, to avoid unacceptably high viscous drag. Fluid that seeps through the gap accumulates in a recovery cavity and is recovered.
US10473218B2
A sealing system includes a first-housing, a second-housing, and a seal. The first-housing defines a mating-surface. The second-housing defines a seal-gland having an inner-wall, a base, and an outer-wall. The second-housing has a perimeter-flange. The seal includes a continuous beam of compliant material compressed within the seal-gland. The seal defines a captured-end disposed within the seal-gland and a free-end extending beyond the second-housing. The seal defines an inner-flange, an outer-flange, a web, and a lip. The lip extends radially outward from and generally perpendicular to the free-end of the outer-flange and is disposed between the perimeter-flange and a portion of the mating-surface. When the second-housing is attached to the first-housing, the inner-flange and the outer-flange forcibly engages the mating-surface of the first-housing, the inner-wall, the base, and the outer-wall of the seal-gland. The lip is compressed between the perimeter-flange and the portion of the mating-surface.
US10473215B2
An elongated fluid actuator arrangement includes a cylinder body comprising a first and second end portion. A piston body comprising a piston force area forming portion and a sleeve portion, which extends through said first and second end portions and exposes first and second outer section outside the cylinder body. A piston rod extends coaxially through said sleeve portion. The arrangement comprises a first and second extendable and contractible cover member each joined to the cylinder body and to the respective sleeve portion outer section.
US10473202B2
A torque transmission apparatus, including: a first vibration damper with a first input part arranged to receive torque from an engine, a first output part and at least one first spring engaged with the first input and output parts; and a torque converter including a cover non-rotatably connected to the first output part, an impeller with at least one first blade and an impeller shell non-rotatably connected to the cover, a turbine with at least one second blade and a turbine shell, an output hub and a planetary gear set including a first component non-rotatably connected to the turbine shell or a second component non-rotatably connected to the output hub.
US10473201B2
A double eccentric positioning apparatus uses two equal offset eccentric bushings to accurately position a tool (such as a drill bushing) in two dimensions. Miniature servo motors and precise gearing control the rotation of each eccentric bushing, which controls the direction of the offset vectors. The offset vectors are used to determine the final position of the drill bushing. The desired rotation angles can be mathematically calculated based on desired position. The inner eccentric bushing is located concentric to the offset of the outer eccentric bushing. This allows any position, within a radius of two times the eccentric offset, to be achieved. The use of worm gearing on the eccentric bushings prevents back-driving of the servo motors, due to the lead angle of the worm gears, and the friction between the worm wheel and worm gear.
US10473191B2
The present disclosure provides a planetary gear train of an automatic transmission including: input and output shafts, first to fifth planetary gear sets respectively having first to third, fourth to sixth, seventh to ninth, tenth to twelfth, and thirteenth to fifteenth rotational elements, a first shaft connected with the second rotational element and the input shaft, a second shaft connected with the fourteenth rotational element and the output shaft, a third shaft connected with the ninth and thirteenth rotational elements, a fourth shaft connected with the tenth and fifteenth rotational elements, a fifth shaft connected with the third and seventh rotational elements, a sixth shaft connected with the sixth rotational element, a seventh shaft connected with the fifth, eighth, and eleventh rotational elements, an eighth shaft connected with the first and fourth rotational elements, and a ninth shaft connected with the twelfth rotational element.
US10473171B2
A torque tube for a brake assembly may include a tube portion having a first centerline axis, a conical back-leg portion extending from the tube portion in a radially outward angled orientation relative to the first centerline axis, and a lip portion disposed at a radially outward end of the conical back-leg portion. The lip portion may have added structural material to improve the structural properties of the torque tube to prevent or mitigate damage that would otherwise be caused by friction-induced vibrations.
US10473164B2
A motoring system for a gas turbine engine having: a reduction gear train having an input and an output; an electric motor operably connected to the input; a clutch operably connected to the output, the clutch in operation engages and disengages the reduction gear train; and a mechanical shaft fuse operably connecting the output to the clutch, the mechanical shaft fuse in operation shears when torque on the mechanical shaft fuse is greater than or equal to a selected value. The mechanical shaft fuse includes a plurality of through holes.
US10473154B2
Embodiments disclosed herein are directed to tilting pad bearing assemblies, bearing apparatuses including the tilting pad bearing assemblies, and methods of using the bearing apparatuses. The tilting pad bearing assemblies disclosed herein include a plurality of tilting pads. At least some of the superhard tables exhibit a thickness that is at least about 0.120 inch and/or at least two layers having different wear and/or thermal characteristics.
US10473147B2
The socket assembly includes a housing with an inner bore that extends from a closed end to an open end. A ball portion of a ball stud is received in the inner bore. A shank portion projects through the open end. A backing bearing is disposed in the inner bore and is movable in a radial direction relative to the housing. The backing bearing presents a first bearing surface which is in sliding contact with the ball portion. A radial ring with an annular shape is also disposed in the inner bore of the housing and presents a second bearing surface which is in sliding contact with an equator of the ball portion. An exit bearing is in the inner bore, and the exit bearing has a curved third bearing surface that is in sliding contact with an opposite hemisphere of the ball portion from the first bearing surface.
US10473144B2
The disclosed embodiments describe a method for producing a bent tubular shaft for a tubular shaft instrument as well as a tubular shaft produced in such manner as well as a tubular shaft instrument with such a bent tubular shaft. The tubular shaft is produced by providing a hollow shaft component and an actuating rod. The actuating rod in this case has at least one bending area in which flexible segments and support segments alternate. The at least one bending area of the actuating rod is provided with a friction-reducing layer before it is inserted into the shaft component in order to create a tubular shaft. The tubular shaft is then bent in an area that corresponds to the at least one bending area of the actuating rod.
US10473138B2
A lightweight construction fastener 30 has two basic elements, a clip body 40 including a connected fastening element 32. The clip body 40 has a first leg 41 and a second leg 42, which are arranged located opposite one another and which are connected to one another by a web 45 on one end. The fastening element 32 includes a flat base plate 34 with two protrusions 35, 36, and a cylindrical holding part 33. On its outer side, the second leg 42 has two frames 43, 44 with apertures 46, 47. They are provided to accommodate the protrusions 35, 36 of the fastening element 32, so that the fastening element is held in the clip body 40 with play, but in a captive manner. The frames 43, 44 are substantially arranged at right angles to the longitudinal axis LA, which is why the orientation of the two protrusions 35, 36 is also oriented along the axis LA.
US10473136B2
A seating assembly for a vehicle comprises: a cushion comprising an outer edge and a plurality of snap-fit-fasteners; and a carrier comprising an outer edge surface and a plurality of snap-fit receivers near the outer edge surface of the carrier arranged to receive the plurality of snap-fit fasteners; wherein the plurality of snap-fit receivers have received and are retaining the plurality of snap-fit fasteners such that the cushion is interconnected with the carrier; and wherein the plurality of snap-fit fasteners and plurality of receivers are arranged to prevent the edge of the cushion from rolling up. The cushion further comprises a lip having an inward facing surface; wherein the cushion at least partially surrounds the carrier with at least a portion of the inward facing surface of the lip facing the outer edge surface of the carrier.
US10473134B2
An enlarged head fastener device and method for manufacturing the same is described. The enlarged head fastener device includes a shank and a head. The head extends outwardly from the shank in a transverse plane to define a head periphery. The head has an anterior side and a posterior side. The anterior side includes a bearing surface and a convergent transition portion that reinforces the head. The convergent transition portion extends between a large end adjacent the bearing surface to a small end adjacent the shank. At least one ridge formation projects from the anterior side of the head providing additional reinforcement. The ridge formation extends continuously between an outboard end positioned on the anterior side of the head adjacent the head periphery and an inboard end positioned on the shank. The head may be centered or offset relative to the shank.
US10473132B2
Apparatus for coupling first and second tubular members includes a first ring coupled to the first tubular member and having a castellated annular first surface with teeth extending in a first direction, and having a projecting tab extending in a second direction opposite the first. The tab is received in a recess in the first tubular member and has a beveled surface. A key is configured to be disposed in the first recess, and has a beveled surface that engages the beveled surface of the tab. A through-bore in the key is aligned with a fastener-receiving bore in the first tubular member and a fastener is disposed in the aligned bores. A second castellated annular surface coupled to the second tubular member has teeth meshing with the teeth of the first castellated annual surface.
US10473126B2
In a control unit of a hydraulic control device, a workload calculation unit calculates the amount of workload cut in a first pump when supply of first oil from the first pump to a continuously variable transmission mechanism through a check valve is switched to supply of second oil from a second pump to the continuously variable transmission mechanism. A workload determination unit determines whether the amount of workload loss of an ACG is more than the amount of workload cut. A motor controller stops a motor or decreases a rotation number if the workload determination unit determines that the amount of workload loss is more than the amount of workload cut.
US10473121B2
The present disclosure provides a turbocharger which reduces noise generated from the wastegate. The turbocharger includes a turbocharger housing, a rotary assembly, and a wastegate door. The turbocharger housing defines a wastegate opening, a resonator proximate to the wastegate opening, a compressor inlet, a compressor outlet, a turbine inlet, and a turbine outlet. The rotary assembly includes a turbine and a compressor attached to one another by a shaft wherein the rotary assembly is disposed in the turbocharger housing. The wastegate door may be moveably affixed to the turbocharger housing.
US10473114B2
The present invention relates to a compressor assembly for a turbocharger. The compressor assembly may comprise a spiral housing with a flow channel which is designed to convey a fluid which can be sucked up from outside the compressor assembly, a compressor outlet flange which is fluidically connected to the spiral housing via the flow channel, and an injection device designed to introduce a fluid from outside the compressor assembly into the flow channel, wherein the injection device is arranged outside the flow channel of the spiral housing.
US10473111B2
A gas turbine engine includes a fan having a plurality of fan blades configured to rotate about a central axis of the gas turbine engine. Each fan blade is configured to pivot about a pitch axis that extends radially away from the central axis to vary a pitch of the fan blade.
US10473110B2
A centrifugal compressor including: a impeller; a wall portion having an opposed surface that is spaced apart from and opposed to a back surface of the impeller; an insertion hole, which is formed in the wall portion, and is configured to receive a shaft inserted into the insertion hole; a bearing, which is provided in the insertion hole or apart from the impeller with respect to the insertion hole, and is configured to axially support the shaft through interposition of grease being a lubricant inside; an electric motor which is provided on a side opposite to the impeller over the wall portion; and an opposed hole, which is formed in the wall portion, is disclosed. The opposed hole has one end opened in the opposed surface and another end opened at a position opposed to a stator of the electric motor on a side opposite to the impeller.
US10473103B2
An impeller assembly with an impeller and a cutter bar plate is used in a chopper pump system which handles liquid material sometimes entrained with large debris and stringy matter. The debris and matter present clogging hazards, which are reduced by a combination of scissoring between sharpened impeller blades and shearing fingers, and between cutting wings and shearing fingers. To make the cutting feature more aggressive, sharpened edges along two of the scissoring edges of the shearing fingers are utilized. Preferably, the sharpened edges are either the result of machined v-notches on the cutting surface of the shearing fingers or of a casted part having a cupped surface. Generally speaking, the impeller assembly comprises an impeller attached to a rotatable pump shaft and includes a back shroud.
US10473099B2
A modular system of reciprocating pumps is to be designed in such a way that any type of said reciprocating pumps can be economically assembled and tested on a flexible assembly device. The magnetic part is a pre-assembled subassembly that can be tested separately and is overmolded with plastic material; the connection point to the pump part has a given connecting contour that allows different types of pump parts of the modular system to be connected; and the pump part is a pre-assembled subassembly that can be tested for the displaced volume thereof. Feed pumps and metering pumps for fuels and aqueous reagents.
US10473093B2
The present invention relates to a soft actuator moving linearly against external stimuli whose expansion and contraction can be actively controlled, suggesting that the actuator of the invention overcomes the problems of the conventional soft actuators, The soft actuator of the present invention can be repetitively driven quickly and accurately by controlling heating and cooling by using thermoelectric effect and, the soft actuator of the present invention can realize bending, tensioning, compression, and rotational driving of a tubular device containing a driver.
US10473087B2
A Multi Axes Wind Turbine of the present invention comprises a multi axes turntable assembly in rotations with a mounted assembly of pairs of planet and sun airfoils for generating a net of substantial powers from generally straight flowing applied wind or airflow. Planet airfoils, been in a fixed rotational orientation relative to and in rotation around a stationary sun rotor, are always facing against applied wind. Different from planet airfoils, sun airfoils are in radial alignment to and in rotation around the sun rotor, and are rotated by applied wind from any direction. In combination, paired planet and sun airfoils alternate as wind shields in rotations around a stationary sun rotor to greatly enhance powers generated while greatly reduce powers lost. A Multi Axes Wind Turbine operated in reverse is a multi-axes tower fan to propel a substantial volume of generally straight flowing wind or airflow.
US10473085B2
A trailing-edge segment of a wind-turbine rotor blade for increasing a profile depth of the rotor blade of a wind turbine. The trailing-edge segment of a wind-turbine rotor blade comprises at least one inner blade segment, having an inner blade shell, at least one middle blade segment, having a middle blade shell. In this case, the at least one middle blade segment and the at least one inner blade segment can be coupled to each other via a coupling means, and the coupling means has at least one shell element, having two inner sides that are parallel to each other and form a receiving space, designed to receive at least one of the inner blade shell or middle blade shell, and the two inner sides each being realized such that they can be connected to at least one of the inner blade shell or middle blade shell, in such a manner that a force acting upon the trailing-edge segment of a wind-turbine rotor blade is introduced centrically into the coupling means.
US10473084B2
Device for generating energy making use of the current of a river (2), with a self-floating paddlewheel (13) and an electric generator set (17) that is coupled to the paddlewheel (13), whereby the device (1) is provided with an immersed housing (3) with an open bottom (4) in which the paddlewheel (13) is rotatably affixed and whereby there is a unit (10) to control the flow of the river (2) at the level of the paddlewheel (13), whereby the speed of the generator set (17) is kept constant by controlling the water level (9) in the housing (3) by placing its internal space (7) under pressure and/or by controlling the aforementioned unit (10).
US10473074B2
A method for molding a connector which includes a connecting element having a cylindrical body and, one arm extending along an arm axis for the L-shaped connector or, two arms extending along two different arm axes for the T-shaped connector, the body being capable of being connected to an injector, and each arm being capable of being connected to the end of a pipe. The molding method includes a) providing a mold having a cavity for a T-shaped connecting element, the cavity including a cavity for a body and two cavities for arms and b) arranging an insert in the cavity for one of the two arms when an L-shaped connecting element is to be molded.
US10473072B2
A fuel pump to fuel tank attachment assembly for a vehicle includes a retainer ring firmly attached to a portion of the fuel tank. The retainer ring is formed of the same material as the material of the fuel tank. A lock ring is positioned over, and secured to the retainer ring. A flange of the fuel pump is positioned and clamped between the retainer ring and the lock ring. The retainer ring and the lock ring circumferentially engage the flange of the fuel pump, in the mounted position of the assembly.
US10473067B1
An air shutoff valve for use on an internal combustion engine includes a gate that is moveable between armed and triggered positions by springs when a release pin is retracted and allows a spring loaded retention pin to retract and release the gate, which is also spring loaded, to drop. The release pin is operated by an actuator.
US10473057B2
A thrust reverser system is provided with an axial centerline. This thrust reverser system includes a first translating element, a second translating element and an actuator mechanism. The actuator mechanism is attached to the first translating element and the second translating element. The actuator mechanism is configured to translate the first translating element along the axial centerline at a first rate. The actuator mechanism is configured to translate the second translating element along the axial centerline at a second rate, which may be different than the first rate.
US10473056B2
A ferrous piston for gasoline powered engines having dimensions which achieve reduced mass and improved performance is provided. The piston crown has a thickness of less than 4 mm and includes valve pockets with an axial clearance between the valve pockets and an uppermost ring groove of less than 1.5 mm. The pin bosses have an axial thickness of less than 3.7% of a bore diameter, which is the largest outer diameter of the piston, measured between a pin bore and the crown at 1 mm from an inner face forming the pin bore. Each pin boss has a radial thickness of less than 3% of the bore diameter measured between the pin bore and a lower end of the pin boss. An undercrown surface presents a projected area of less than 45% of a total piston bore area, wherein the total piston bore area is πBD2/4, BD being the bore diameter.
US10473047B2
An engine includes an exhaust gas control apparatus that is configured to store NOx and react NOx with a reduction agent. A control device for the engine includes an electronic control unit. The electronic control unit is configured to: (i) execute a rich spike control, the rich spike control is a control executed to temporarily change an in-cylinder air-fuel ratio from a leaner air-fuel ratio than the stoichiometric air-fuel ratio to the stoichiometric air-fuel ratio or a richer air-fuel ratio than the stoichiometric air-fuel ratio, and (ii) vary an overlap amount of an intake valve and an exhaust valve such that the overlap amount is less during execution of the rich spike control than during non-execution of the rich spike control, in an operation range where a pressure of the intake port becomes higher than a pressure of the exhaust port.
US10473031B2
Systems and methods for preventing fuel leakage in a gas turbine engine are provided. A fuel accumulation system includes a control valve section fluidly coupled to a fuel manifold passage and an accumulator valve section fluidly coupled at a first side to the control valve section. The control valve section is configured to control expansion of a fluid flowing in the fuel manifold passage. The accumulator valve section is configured to receive fluid expanded in the fuel manifold passage via the control valve section.
US10473030B2
An aircraft engine includes a rotating structure and a casing circumferentially surrounding the rotating structure. The aircraft engine further includes an acoustic panel for noise reduction circumferentially surrounding the rotating structure. The acoustic panel is disposed proximal the casing. Furthermore, the acoustic panel includes a plurality of acoustic panel members. In addition, the acoustic panel is secured to the casing by at least one securement mechanism such that the acoustic panel is substantially circumferentially fixed relative to the casing.
US10473028B2
A clutched compressor section of a gas turbine engine coupled to a rotor shaft. The clutched compressor section includes at least one decoupleable rotor stage, the decoupleable rotor stage switchable between a coupled condition and a decoupled condition with a clutch mechanism, the coupled condition coupling the decoupleable rotor stage with the rotor shaft, the decoupled condition decoupling the decoupleable rotor stage from the rotor shaft.
US10473024B2
A turbocompound unit for converting energy of an exhaust gas from an internal combustion engine to torque increase of a crankshaft of the internal combustion engine includes a turbine arrangement and an arrangement configured to operatively connecting the turbine arrangement to the crankshaft is a hydrodynamic coupling and freewheeling arrangement. The turbocompound unit further includes a brake arrangement, wherein the brake arrangement and the freewheeling arrangement are located on an opposite side of the hydrodynamic coupling in relation to the turbine arrangement.
US10473023B2
A vehicle thermal management system includes an engine, a coolant pump, a first heat exchanger, a first valve in communication with the first heat exchanger, a second valve having a plurality of outlets, a second heat exchanger in communication with a first of the plurality of outlets, a third heat exchanger in communication with a second of the plurality of outlets, a bypass fluid conduit in communication with a third of the plurality of outlets, and a controller that determines a first potential benefit based upon a loss function of the second heat exchanger, determines a second potential benefit based upon a loss function of the third heat exchanger, compares the first potential to the second potential, and proportionally distributes flow between the first heat exchanger, the second heat exchanger, the third heat exchanger, and the bypass fluid conduit based upon the comparison.
US10473017B2
An exhaust-gas aftertreatment system for an internal combustion engine, having a catalyst device, which is designed to catalytically react at least one exhaust-gas component with a reactant, and a reactant-metering device, which is arranged upstream of the catalyst device along a flow path of the exhaust gas through the exhaust-gas aftertreatment system. The reactant-metering device has at least one exhaust-gas flow nozzle.
US10473015B2
A pressure sensor includes: a housing; a substrate that is fixed within the housing, that includes a first side that is in contact with a fluid of an exhaust aftertreatment system, and that flexes based on a pressure of the fluid; a first voltage divider that is connected between a first reference potential and a ground potential and that varies a first potential based on flexing of the substrate; and a second voltage divider connected in parallel with the first voltage divider between the first reference potential and the ground potential and that varies a second potential based on flexing of the substrate. A pressure control module is configured to selectively switch switches to connect and disconnect different reference potentials to and from an amplifier, to sample an output of the amplifier, and to convert samples of the output of the amplifier into corresponding digital values.
US10473008B2
A system and method for activating on a user interface an indicator of a condition of a lubricant in a machine module. The system may comprise a controller and a user interface. The controller may be configured to, for each of a first time window and a second time window: receive a plurality of lubricant characteristics and measured lubricant temperatures, calculate an adjusted lubricant characteristic, and determine a slope based on the plurality of adjusted lubricant characteristics. The controller may further determine a change in slope, and generate a signal to activate the indicator on the user interface based on the change in slope, wherein, if the change in slope exceeds a threshold, the indicator is a lubricant changed indicator.
US10473005B2
A lubrication structure for an internal combustion engine includes a crankcase, an oil pump, and a relief valve. The crankcase is configured by connecting an upper crankcase on a mating surface of a lower crankcase, and has an oil pan. The oil pump and the relief valve are installed in the lower crankcase. The oil pump sucks oil in the oil pan through a suction passage, and discharges the oil into a discharge passage. The relief valve performs a valve-opening operation according to pressure of oil in the discharge passage to return surplus oil in the discharge passage to the suction passage through a surplus passage. These passages are formed in the lower crankcase. A relief valve housing section housing the relief valve, and the surplus passage allowing the relief valve housing section and the suction passage to communicate with each other, are provided to communicate with the mating surface.
US10473003B2
A valve drive for an internal combustion engine may include a cam shaft, at least one cam follower, and at least one adjusting device. The at least one adjusting device may include a first adjustable engagement element and a second adjustable engagement element. The first engagement element may not contact a first guide in an initial position, and may cooperate with the first guide in a switching position. The second engagement element may not contact a second guide of a slide guide in an initial position, and may cooperate with the second guide in a switching position. The at least one adjusting device may further include a switching arrangement that may include a first control element mounted to the first engagement element and a second control element mounted to the second engagement element. The first control element and the second control element may be controllable via the switching arrangement.
US10472998B2
A rocker arm includes an outer arm with an outer follower and an inner arm which selectively pivots relative to the outer arm, the inner arm having an inner follower. A lost motion spring biases the inner arm to pivot relative to the outer arm. A lock pin which slides between a coupled position and a decoupled position. A pivot shaft includes a first portion a second portion centered about a first pivot shaft axis and a third portion located between the first portion and the second portion that is centered about a second pivot shaft axis which is parallel to, and laterally offset from, the first pivot shaft axis. The third portion supports the inner arm.
US10472992B2
The disclosed apparatus and control system produces a single, on demand, energetic gaseous working fluid from any heat source. Working fluid in a liquid phase is released into a heat exchange tube in the form of very fine droplets or atomized mist, where it is rapidly heated to its gaseous phase. The gaseous working fluid can continue to absorb heat before exiting the heat exchange tube to perform work. The disclosed system controls the release of working fluid into the heat exchange tube and/or the heat energy to which the tube is exposed, resulting in a flow of energetic gaseous working fluid that can be quickly adjusted in response to changing conditions without a large pressure vessel.
US10472991B2
A foreign substance removal apparatus for a gas turbine includes a combustor casing having a first cooling air passage formed in a tangential direction of a combustor in a gas turbine in order to move cooling air into the combustor, a first foreign substance collection unit disposed on a flow path in the first cooling air passage in order to primarily filter foreign substances contained in the cooling air, a second cooling air passage extending radially toward a turbine blade in a circumferential direction of a torque tube located in the combustor, and a second foreign substance collection unit disposed on a flow path in the second cooling air passage and communicating with the second cooling air passage to secondarily filter foreign substances contained in the cooling air introduced through the first cooling air passage.
US10472989B2
According to some embodiments, a ceramic matrix composite (CMC) hanger sleeve is provided for retaining a ceramic matrix composite shroud panel. The sleeve may be connected to an upper hanger by a retainer or a casing. The hanger sleeve includes a radially inward opening with a flowpath panel disposed therein. When the CMC flowpath panel is worn due to time, rubs or both, the panel may be replaced without need to replace the entire assembly.
US10472981B2
A gas turbine engine component according to an exemplary aspect of the present disclosure includes, among other things, a body having a first outer face meeting a second outer face at an intersection, the body having a plurality of apertures extending from an opening in the first outer face to an opening on the second outer face; and a coating filling at least a portion of the plurality of apertures.
US10472978B2
A gas turbine engine fan blade apparatus is disclosed comprising a reverse pitch rotatable mounting and an aerofoil part. The aerofoil part comprises radially inner and radially outer portions that are separated by an interface extending from a leading edge of the aerofoil part to a trailing edge of the aerofoil part. The reverse pitch rotatable mounting locates the radially inner and radially outer portions with respect to one another. The reverse pitch rotatable mounting and separation at the interface permit relative pitch change rotation between the radially inner and radially outer portions such that one of the radially inner and radially outer portions is rotatable to a reverse pitch configuration by comparison with the other portion.
US10472969B2
A cooling structure for a turbine includes a plurality of disks configured to rotate integrally with blades, the disks being arranged along a rotational axis; and the disks have disk holes defined therein and arranged in a circumferential direction for supplying cooling air for cooling the blades to downstream disks. At least one of the disk holes is set such that, when a rotational direction of the disk is defined as a positive direction and a direction opposite the rotational direction is defined as a negative direction, an outlet absolute circumferential velocity vector which is a component in the rotational direction of a velocity vector of the cooling air at an outlet of the disk hole is smaller than an inlet absolute circumferential velocity vector which is a component in the rotational direction of a velocity vector of the cooling air at an inlet of the disk hole.
US10472958B2
Techniques for determining properties of a spotting fluid include positioning a member of a test apparatus into a prepared mudcake sample at a specified depth, the mudcake sample associated with a drilling fluid and including a specified thickness; circulating a flow of the spotting fluid to contact the prepared mudcake sample in a test cell; soaking the prepared mudcake sample in the spotting fluid for a specified time duration; subsequent to the specified time duration, detecting a force exerted on the member relative to a displacement distance of the member from the specified depth in the mudcake sample during removal of the member from the mudcake sample; recording, with the test apparatus, the detected force relative to the displacement distance; and determining, with the test apparatus, one or more properties associated with the mudcake sample based on the recorded force relative to the displacement distance.
US10472957B2
Systems, computer-implemented methods, and non-transitory computer-readable medium having a stored computer program provide characterization of multiphase fluid flow (MPF) using approximate entropy calculation techniques to enhance measuring and monitoring of a flow regime in a segment of pipe for hydrocarbon-production operations. The systems and methods can be optimized using principal component analysis.
US10472951B2
A downhole ultrasonic transducer (10) used to transmit and/or receive ultrasonic waves in a hydrocarbon well where a fluid is present comprises: a metal housing (11) defining an internal cavity (12) isolated from the fluid of the hydrocarbon well (100) by a membrane wall (13) made of metal or metal alloy; a piezoelectric element (14) mounted inside the internal cavity (12), the piezoelectric element (14) having a front side (20) mechanically coupled on the membrane wall (13); wherein: the internal cavity (12) is at a pressure unrelated to a hydrocarbon well pressure; a back side (21) of the piezoelectric element (14) is arranged to be free to oscillate in the internal cavity (12) so as to generate a high acoustic impedance mismatch between the piezoelectric element (14) and the internal cavity (12) at the back side (21) and to maximize acoustic transmission at the front side (20); and a thickness (ei) of the membrane wall (13) is such that there is a common resonance between the membrane wall and the piezoelectric element thereby achieving high acoustic transmission through the membrane wall (13), and such that the membrane wall (13) is suitable to resist to the hydrocarbon well pressure.
US10472948B2
Techniques and apparatus are provided for improved diagnostics of downhole dynamometer data for control and troubleshooting of reciprocating rod lift systems. A method for pump fillage determination for a reciprocating rod lift system is provided. The method generally includes measuring downhole data during a pump cycle, wherein the downhole data comprises a first plurality of data points associated with an upstroke of the pump cycle and a second plurality of data points associated with a downstroke of the pump cycle, each data point comprising a rod position value and an associated rod load value; converting the data points to non-dimensional data points, calculating non-dimensional slope values between non-dimensional data points; and determining pump fillage based, at least part, on the calculated non-dimensional slope values.
US10472944B2
A drilling system and associated systems and methods for monitoring, controlling, and predicting vibration of a drilling operation. The vibration information can include axial, lateral or torsional vibration of a drill string.
US10472942B2
A method and system in which foams are used (instead of, or in addition to, NCG) to maintain pressure in a mature chamber during blowdown operations of a SAGD process or other enhanced oil recovery process. The foam occupies the depleted void space within the mature chamber after injection ceases, maintaining pressure, and improving blowdown performance. This use of the foam in the method and system also improves the performance of less mature chambers that are being operated at higher pressure adjacent to the mature chamber in blowdown. Foaming agents, such as metal carbonates, bicarbonates, and hydroxides, surfactants or any other colloidal foams, aerosols, hydrosols, emulsions or dispersions can be utilized. The method and system can be utilized in conjunction with other known art, such as heat scavenging in the chamber, or enhanced oil recovery utilizing foams, to displace oil in the chamber.
US10472935B2
The present invention concerns a feedback control method for adjusting the proppant concentration in a fracturing fluid that is utilized in stimulation of an underground formation.
US10472934B2
A downhole drill pipe may comprise a transducer disposed therein, capable of converting energy from flowing fluid into electrical energy. A portion of a fluid flowing through the drill pipe may be diverted to the transducer. After passing the transducer, the diverted portion of the fluid may be discharged to an exterior of the drill pipe. To generate electrical energy while not obstructing the main fluid flow from passing through the drill pipe, the transducer may be disposed within a lateral sidewall of the drill pipe with an outlet for discharging fluid exposed on an exterior of the lateral sidewall.
US10472932B2
An overtensioning fastening tool to maintain control of oil and gas equipment and prevent migration upon failure. The overtensioning fastening tool is comprised of one or more flapper components, housed in a primary enclosure, a hydraulic deployment system and/or electric deployment system, housed in a secondary enclosure, a sensor, and a manual activation component. The overtensioning fastening tool is designed to grip and hold equipment and tooling, such as cables.
US10472930B2
A downhole actuator typically for a downhole tool such as a valve, and typically for incorporation in a string of tubulars in an oil or gas well has a central axis with radially movable counterweights on opposite sides of the axis, which move radially outward to change the activation state of the actuator. The counterweights are supported by link arms which control the movement of the counterweights in response to centrifugal force created by rotation of the body, for example, during rotary drilling operations of the string. Radial outward movement of the counterweights typically transmits axial forces between sleeves at the upper and lower ends of the counterweights, so when the counterweights move radially outward, the upper and lower sleeves approach one another, which typically triggers the actuator.
US10472905B2
A tong and method, in which the tong includes a first plate, and a gear that is rotatable relative to the first plate. The gear defines a slot laterally therethrough. An inner surface of the gear includes at least three cam surface. The tong also includes at least three jaws coupled to the first plate such that the at least three jaws are radially movable with respect to the first plate and are prevented from circumferential movement with respect thereto. The at least three jaws are engageable with the at least three cam surfaces such that rotation of the gear relative to the first plate causes the at least three jaws to move in a radial direction between an extended position and a retracted position.
US10472903B2
A fingerboard that includes a first finger having a longitudinal axis and proximal and distal ends, a latch assembly mounted on the distal end of the finger, the latch assembly including first and second opposed bearing faces defining a first gap therebetween, a latch having first and second latch ends, the first latch end being pivotably mounted in the first gap so as to allow the latch to pivot between open and closed positions in a plane normal to the longitudinal axis of the first finger, and third and fourth opposed bearing faces defining a second gap therebetween, the second longitudinal space positioned to receive the second end of corresponding latch on an adjacent finger. The latch assembly may be detachably mounted on the finger.
US10472898B2
A superabrasive-impregnated earth-boring rotary drill bit includes cutting features extending outwardly from a bit body in a nose region of the drill bit. The cutting features comprise a composite material including superabrasive particles embedded within a matrix material. The cutting features extend from an outer surface of the bit body by a relatively high average distance. Methods of forming a superabrasive-impregnated earth-boring rotary drill bit include the formation of cutting features that extend outwardly from a bit body of a drill bit in a nose region of the drill bit. The cutting features are formed to comprise a particle-matrix composite material that includes superabrasive particles embedded within a matrix material. The cutting features are further formed such that they extend from the outer surface of the bit body by a relatively high average distance.
US10472891B2
A hydraulic gentle vibration speed-enhancing drilling tool has an upper joint, a power assembly, a flow regulating valve assembly and a force transmission assembly. The upper end of an outer shell of the power assembly is in threaded connection with the upper joint of the drilling tool, at the lower end thereof, internal steps having outer octagonal structure are arranged to limit the lower joint; a middle section of the lower joint is of outer octagonal structure, with the lower end in threaded connection with an adapter; and the power assembly is of turbine set structure or screw-type mud motor structure for producing driving force under the action of hydraulic force and driving an upper rotating shaft. The upper rotating shaft is arranged on a load bearing ring, and the lower end thereof is in threaded connection with a lower rotating shaft.
US10472880B2
Certain example embodiments of this invention relate to insulating glass (IG) units including three substantially parallel spaced apart glass substrates, wherein at least two of the surfaces include low-emissivity (low-E) coatings and at least some of the non-low E coated surfaces have antireflective (AR) coatings disposed thereon. In certain example embodiments, low-E coatings are provided on the second and fifth surfaces of the IG unit, and each internal surface of the IG unit that does not support a low-E coating does support an AR coating. Additional AR coatings may be provided on one or both of the outermost surfaces in certain example embodiments. In some cases, the center substrate need not be heat treated because of the reduced absorption enabled by providing the low-E coatings on the two outermost substrates, as well as the reduced heat accumulation in the center lite itself and in the two adjacent spacers.
US10472876B2
A window regulator (1) provided in a door (9) of a vehicle to raise and lower a windowpane (90) in the door (9) includes a guide rail (20) arranged along the travel direction of the windowpane (90), a wire (3) extending along the longitudinal direction of the guide rail (20), and a traveling body (4) that is guided by the guide rail (20) and travels together with the windowpane (90). The traveling body (4) includes a drum (40) with a part of the wire (3) wound thereon, a motor (5) generating a drive force that rotates and drives the drum (40), and a housing (6) that holds the drum (40) and the motor (5). The motor (5) is more outwardly situated in a vehicle width direction than the guide rail (20) in the door (9).
US10472874B2
A pneumatically actuated gate assembly, and a kit for making the assembly are provided. The assembly comprising: a gate with an at least one hinge; a battery; a compressed gas cylinder; a first support pivotally supporting the gate with the hinges; a second support; a latch movably mounted on the gate; a keeper for releasable engagement with the latch, the keeper mounted on the second support; a compressed gas system in fluid communication with the compressed gas cylinder; a gate pneumatic system in fluid communication with the compressed gas system, and including a gate pneumatic ram pivotally attached to the first support at a proximal end and attached to the gate at a distal end; a latch pneumatic system in fluid communication with the compressed gas system, and including a latch pneumatic ram attached to the gate and the latch; and a controller, wherein the compressed gas system is configured to provide a controllable pressure of gas to the gate pneumatic system and the latch pneumatic system under control of the controller. A method of using the assembly is also provided.
US10472861B2
A knob claim lock has been developed. The knob clamp lock includes a frame piece with two slots and a shackle opening that fits over a lock piece with two tabs and a matching shackle opening. The tabs and slots fit together to make sure the shackle openings align to allow the knob clamp lock to be secured.
US10472857B2
A locking cap having a push button reset and method for operating the locking cap having a push button reset are disclosed. The locking cap with a push button reset system is a deterrent to keep medications in the correct hands.
US10472854B2
A method for creating a key and a female lock part for a lock, whereby just a few parts are used to create a high number of unique locks. A coding part and a blank are affixed to each other to create the key or female lock part. Coding part and blank each have a contact surface, which, when brought together, can rotate continuously relative each other. The coding part is placed on the blank at a desired rotational position and affixed in that position, either by welding or adhesively. To create a lock with a unique lock function, two coding parts with mating contact surfaces are each attached to a blank, The key and female lock part so made function only with each other. In this way, the same basic coding part and basic blank can be used to create a large number of different locks.
US10472851B1
An improved fence anchor device for securing fence fabric extending along a fence structure. The fence anchor device includes an elongated stake having a tine end imbedded within the ground, and a clasp end positioned proximate the fence fabric. A tether is rotatably captured within a keeper provided in said clasp end, and the tether includes a first angled leg having a first hook end, and a second angled leg having a second hook end spaced apart at a distance that corresponds with a distance between a first fence link and a second fence link located along the fence fabric.
US10472842B2
An automated parking turntable includes a driver walking unit with a rack having multiple loading forks and a vehicle conveyor for loading and unloading a vehicle to and from the rack. The automated parking turntable further includes a rotating plate having a vehicle standby unit in which a vehicle stands by opposite a driver getting on/off door, the rotating plate rotating to change the front/rear/left/right direction of the vehicle. Multiple fork bars are formed on the vehicle standby unit of the rotating plate and arranged in parallel with each other at a predetermined interval so as to be perpendicular to the direction of movement of the vehicle in the outer straight range of the rotating plate. The multiple fork bars include front and rear fork groups spaced from each other to support the front wheels and rear wheels of the vehicle, respectively.
US10472836B2
The present disclosure relates to reinforcement devices, systems and methods for use in constructing new structures, including post frame structures. Specifically, the present disclosure relates to reinforcement devices, systems and methods for replacing traditional wood and/or precast concrete columns utilized in building a new construction foundation, with a height adjustable foundation column assembly constructed from a corrosion resistant material. The present disclosure also relates to reinforcement devices, systems and methods useful for reinforcing existing post frame structures, particularly those with framing elements requiring repair.
US10472831B1
An insulation support system preferably includes an edge-folded ceiling liner sheet, an encapsulated package and a plurality of compressible thermal spacers. The edge-folded ceiling liner sheet includes opposed folded-up edges. The folded-up edges have sufficient length to clear pinch points along structural beams. The edge-folded ceiling liner sheet is fan-folded for retention in the encapsulated package. A pressure absorbing expansion spacer prevents roof or wall panel rumble noises and may be applied directly to roof or wall structural members, or may include a snap clip bonded to a pressure absorbing expansion spacer material. A bottom of the pressure absorbing expansion material is bonded to a top of the snap clip. The snap clip is attached to flanges of purlins or girts eliminating the need for stand-off roof panel clips, rigid thermal blocks and severe compression of an extra layer of blanket fiber glass insulation.
US10472828B2
In various embodiments, a tile system for mounting structures to a roof may comprise a base assembly, a fastener, a seal, a flashing, and a mounting bracket. The fastener may be installable on the base assembly. The seal may be installable on the fastener. The flashing may be configured to replace a roof tile. Moreover, a protrusion may be field formed in the flashing during installation of the tile system by driving the fastener through the flashing in response to the base assembly being positioned on the roof surface. The bracket may be installable on the fastener and configured to compress the flashing against the seal and the base assembly.
US10472810B2
An inflow fitting for the filling of a cistern comprises a housing, an outlet pipe, and a water passage formed in the housing and outlet pipe and having an entry and an exit, a float-controlled valve, which is disposed in the water passage and which shuts off the water passage or opens it up in the filling operation, and a float, which cooperates with the valve, for controlling the valve, wherein the float has a cavity that is fillable with water, and at least one buoyancy chamber. The inflow fitting further comprises a supplemental water tap, branched off from the water passage, for filling the said cavity in order to provide an additional weight. In the water passage, in the region of the supplemental water tap, is arranged at least one backflow element, with which a backflow can be provided in the region of the supplemental water tap for the pressure-independent removal of supplemental water.
US10472805B1
A hydraulic drive unit of a hydraulic excavator is configured to include a first hydraulic pump (P1) that discharges a hydraulic oil for activating a boom cylinder (36) and the like, a first electric motor (M1) that drives the first hydraulic pump (P1), a hydraulic pump for revolution (P2) that discharges a hydraulic oil for activating a revolution motor (26), a second electric motor (M2) that drives the hydraulic pump for revolution (P2), and a motor control device (150) that controls the rotation of the first electric motor (M1) and that of the second electric motor (M2). The motor control device (150) is configured such that when the revolution of the revolving body is not activated by the revolution motor (26), control to deactivate the second electric motor (M2) is performed.
US10472802B2
A leak prevention apparatus for an operator cabin of a construction equipment is provided which, in the case of the construction equipment being washed, or rainfall during the running of the construction equipment, can prevent water from leaking into the operator cabin includes a leakage prevention apparatus for an operator cabin of a construction equipment including a first plate which is fixed to the frame of an operator cabin of a construction equipment, a second plate which is connected to the first plate and diverges from the first plate in the opposite direction to a lower glass of the operator cabin, and a damper which is mounted on the second plate and is formed displaceably toward the lower glass of the cabin so as to control the pressure which presses the lower glass.
US10472800B2
An apparatus for backfilling a trench and, more particularly, an apparatus for laying a pipeline bed layer in a trench and for laying a pipeline bedding layer once a pipeline is laid in the trench. The apparatus comprises a multi-deck screen vibrating unit. The upper deck screen comprises finger tines or a grizzly arrangement.
US10472798B2
A work vehicle grade control system for a vehicle having a plurality of pneumatic tires, a frame supported by the plurality of tires, and a grader blade configured to move with respect to the frame to grade a surface. The grade control system includes an actuator operatively connected to the grader blade, wherein the actuator is configured to move the grader blade with respect to the frame based on one or more tire pressures. The grade control system includes control circuitry configured to identify a current grade of the surface; identify a position of the grader blade with respect to the surface; identify the one or more tire pressure of one or more of the plurality of tires; and adjust the position of the grader blade with respect to the frame based on the identified current grade and the identified tire pressure of the one or more plurality of pneumatic tires.
US10472791B1
Certain aspects of removing submerged piles of offshore production platforms can be implemented as methods. A top deck of a fixed offshore platform installed on a mudline of a body of water is removed. An upper structure of the fixed offshore platform is removed. The upper structure is below the top deck. A lower structure is secured to the mudline by one or more structural piles remaining. The one or more structural piles, which are housed within one or more members of the lower structure, are driven below the mudline. The lower structure of the fixe offshore platform is removed. The one or more structural piles are left below the mudline.
US10472789B2
The invention relates to an arrangement for vertically introducing drainage ribbons into a subsoil, comprising an hollow mandrel and a drainage ribbon that is fed through the mandrel, wherein the mandrel comprises a permanent section with a first elongate mandrel profile and a mandrel drive, and a replacement section at the end of the mandrel, wherein the replacement section comprises a second elongate mandrel profile that is joint with the end of the first mandrel profile by means of a weld, a bottom face at the bottom end of the second mandrel profile, and a push bar and a spring that biases the push bar towards its extended position with respect to the bottom face, wherein the mandrel drive comprises a drive cable that extends through the hollow mandrel and that is at one end operatively connected with the push bar by means of a releasable coupling.
US10472781B2
The present invention provides an anchor pile and installation method for the same, which includes insertion hole portions and guide portions formed in the side surface of a hollow pipe. In a state where a resistance member formed of a material that can be elastically deformed is stored within the pipe, the anchor pile is driven into the ground. When an auxiliary tool is used to pull up the resistance member in a vertical direction within the pipe after the anchor pile is driven into the ground, the protrusion portions of the resistance member slide on the guide portions and are deformed so as to be opened and extended toward the insertion hole portions. The protrusion portions of the resistance member are protruded from the insertion hole portions toward the ground and function to provide the resistance force of the anchor pile in the ground.
US10472779B2
A road finisher including an undercarriage, a chassis, a hopper, a paving screed, and a lifting device for lifting the chassis relative to the undercarriage at least in a rear region of the road finisher. The lifting device comprises a rocker mounted rotatably around an undercarriage rotational axis at an undercarriage-side bearing surface and rotatably around a chassis rotational axis at a chassis-side bearing surface. The lifting device further comprises a length-variable adjustment member connecting a chassis-side link point to a rocker-side link point and configured to change a distance between the chassis-side link point and the rocker-side link point by changing its length to selectively lift or lower the chassis relative to the undercarriage. A distance between the chassis rotation axis and the undercarriage rotation axis is greater than a distance between the chassis rotation axis and the chassis-side bearing surface.
US10472777B1
A tow point assembly for attaching a screed to a traction unit of a paver, the tow point assembly including a tow arm having a forward end and a rearward end adapted to be secured to the screed, a tow point support adapted to be secured to the traction unit, and a tow point lift mechanism. The tow point lift mechanism has a first end adapted to be secured to one of the traction unit and the tow point support, and a second end connected to the forward end of the tow arm. The forward end of the tow arm defines a pull point axis where the traction unit pulls the screed and a pivot axis where the tow arm pivots relative to the traction unit. The pull point axis and the pivot axis are coaxial.
US10472772B2
A system for a screwless rail fastening includes a spring element and a supporting collar. The spring element has a bearing section, a curved section, a holding-down section, aligned in the opposite direction to the bearing section, a curved section curved in the direction of the bearing section, and a locking section aligned transversally to the bearing section. The supporting collar includes a fastening section for retaining the supporting collar on the foundation, a carrier section supported by the fastening section, a bearing recess formed on the carrier section for mounting of the bearing section, and a locking head supported by the carrier section on which a counter-bearing for the locking section is formed so that the locking section is retained in a position relative to the bearing section of the spring element.
US10472763B2
The present invention relates to an artificial leather using polyester, the artificial leather comprising: a base substrate layer made of a polyester fabric; an adhesive layer deposited on one surface of the base substrate layer and made of a polyester copolymer; and a skin film layer deposited on one surface of the adhesive layer and made of a polyetherester-based block copolymer.
US10472756B2
The invention relates to a tank for washing a warp thread, provided with a device for intensifying the washing effect set in rotation inside the tank. Each device includes a body having cylindrical geometry, having circular cross section, which has a plurality of longitudinal bars arranged along the cylindrical side surface of the device. Between each pair of adjacent bars a longitudinal slit is defined. The body also has a pair of end elements extending radially, forming the opposite bases of the body and configured to support and enclose the bars. The body also has a pair of opposite rotation pins, obtained on the respective outer surfaces of the end elements and that extend along an axial direction and parallel to the direction of extension of the bars. The body also has a tangential turbodynamic flow generator, arranged inside the body and configured to intensify the interchange between the washing liquid and the warp thread through the longitudinal slits during the rotation of the device.
US10472752B2
A sewing machine including a detection portion that detects a movement amount of a workpiece, a sewing machine motor that serves as a driving source for vertical movement of a needle bar, and a control device that controls the sewing machine motor based on the detection result by the detection portion and performs control to maintain a constant stitch pitch. The control device lengthens a period for obtaining an output of the detection portion when the movement amount of the workpiece per unit time based on the detection result by the detection portion is decreased, and shortens the period for obtaining the output of the detection portion when the movement amount of the workpiece per unit time based on the detection result by the detection portion is increased.
US10472743B2
A dipped and heat-set aramid cord, comprising a plurality of cord plies having a spacing between the plurality of cord plies, wherein a TASE at 2.0% elongation of the aramid cord is less than 2.0 cN/dtex; wherein the spacing between the plurality of cord plies is more than 10% and less than 80% of a cord diameter (D) of the cord plies.
US10472738B2
A method for producing a flame-proofed fiber by performing a flame-proofing treatment on a carbon-fiber precursor fiber bundle with a heat treatment furnace including a gas supply blowout nozzle, including: a nozzle body including an inclined plate that guides a gas flowing straightly from a gas inlet port to a rectification board; and the rectification board which rectifies the flow of the gas to blow out toward a yarn from a gas outlet port, where a gas introduction direction in the nozzle is different from a gas blowing out direction, a gas guiding zone is between the inclined plate and the rectification board and includes a guide plate in a space between the gas inlet port and the rectification board and divides the gas supplied from the inlet port into two or more streams, and at least one of between the inclined plate and the guide plate or between the guide plates, an upstream passage width W1 perpendicular to a gas flowing direction inside the gas passage and any downstream passage width W2 satisfy W1≥W2.
US10472736B2
An epitaxial wafer includes a silicon carbide film having a first main surface. A groove portion is formed in the first main surface. The groove portion extends in one direction along the first main surface. Moreover, a width of the groove portion in the one direction is twice or more as large as a width of the groove portion in a direction perpendicular to the one direction. Moreover, a maximum depth of the groove portion from the first main surface is not more than 10 nm.
US10472731B2
A method of forming a semiconductor structure is disclosed. A substrate is provided with a pad metal and a fuse metal formed thereon. A liner and an etching stop layer are formed at least covering a top surface of the fuse metal. A dielectric layer is formed on the substrate and a passivation layer is formed over the dielectric layer. A pad opening and a fuse opening are defined in the passivation layer. A first etching step is performed to remove the dielectric layer from the pad opening and the fuse opening to expose a top surface of the pad metal from the pad opening and an upper surface of the etching stop layer from the fuse opening respectively. A second etching step is performed to remove the etching stop layer from the fuse opening until an upper surface of the liner is exposed.
US10472729B2
A method is provided for manufacturing a blade. The blade comprises an airfoil (100) having: a root end and a tip (106); a metallic substrate (102) along at least a portion of the airfoil; and an anodized layer (154). The method comprises roughening the tip to form protrusions (158′; 402′) and anodizing to form the anodized layer so that the protrusions form an abrasive (156; 400).
US10472723B2
Provided is a method of preventing reverse current flow through an ion exchange membrane electrolyzer, which method is capable of preventing a reverse current from being generated after stopping operation of the ion exchange membrane electrolyzer.A method of preventing reverse current flow through an ion exchange membrane electrolyzer 100, the ion exchange membrane electrolyzer 100 having an anode chamber 107 housing an anode, a cathode chamber 110 housing a cathode, an anode solution-supplying manifold 121 to feed anode solution to the anode chamber 107, and a cathode solution-supplying manifold 124 to feed cathode solution to the cathode chamber 110. After stopping operation of the ion exchange membrane electrolyzer 100, injected is a low electrical conductivity material with an electrical conductivity lower than that of the anode solution or the cathode solution to at least one of an anode solution-supplying pipe 127 which supplies the anode solution to the anode solution-supplying manifold 121 from an anode solution tank 123 and a cathode solution-supplying pipe 128 which supplies the cathode solution to the cathode solution-supplying manifold 124 from a cathode solution tank 123.
US10472720B2
The present disclosure relates generally to the field of conversion coating. More specifically, the present disclosure relates to improved methods for improving efficiency of chromium conversion coat processing lines.
US10472719B2
A nozzle for supplying a fluid includes a tubular part including a tubular passage thereinside and a fluid discharge surface having a plurality of fluid discharge holes formed therein along a lengthwise direction of the tubular passage. A partition plate is provided in the tubular passage and extends along the lengthwise direction so as to partition the tubular passage into a first area including the fluid discharge surface and a second area without the fluid discharge surface. The partition plate has distribution holes whose number is less than a number of the plurality of fluid discharge holes in the lengthwise direction. A fluid introduction passage is in communication with the second area.
US10472709B2
An electroformed binary copper alloy comprising copper and X, where X is selected from the group consisting of Cr, Fe, W, Mo, B, Co, Ag, and P, having a yield strength of at least 600 MPa and an electrical conductivity of at least 20% IACS is disclosed.
US10472708B2
A method of hot forming an aluminum alloy component may include heating the aluminum alloy component in a heating furnace to a solutionizing temperature, cooling the aluminum alloy component to a desired forming temperature, deforming the aluminum alloy component into a desired shape in a forming device while the aluminum alloy component is at the desired forming temperature, maintaining a constant temperature during the deformation of the aluminum alloy component, and quenching the aluminum alloy component to a low temperature below a solvus temperature.
US10472707B2
An Al—Zn—Mg—Cu alloy with improved damage tolerance-strength combination properties. The present invention relates to an aluminum alloy product comprising or consisting essentially of, in weight %, about 6.5 to 9.5 zinc (Zn), about 1.2 to 2.2% magnesium (Mg), about 1.0 to 1.9% copper (Cu), preferable (0.9 Mg−0.6)≤Cu≤(0.9 Mg+0.05), about 0 to 0.5% zirconium (Zr), about 0 to 0.7% scandium (Sc), about 0 to 0.4% chromium (Cr), about 0 to 0.3% hafnium (Hf), about 0 to 0.4% titanium (Ti), about 0 to 0.8% manganese (Mn), the balance being aluminum (Al) and other incidental elements. The invention relates also to a method of manufacturing such as alloy.
US10472703B2
The metal alloy is a possible replacement for/alternative to cupronickel cladding material used on currently-circulating clad coins. In the preferred embodiment, the (steel) metal alloy cladding material comprises 73-77% iron, 22-26% nickel, 0.2-0.5% carbon, and 1-5% manganese. The cladding material has an International Annealed Copper Standard (IACS) conductivity of less than 2%, a permeability of approximately 1.0-1.1, and a hardness value of 50-70 HRC 15 T (Rockwell Hardness). In alternative embodiments, the steel alloy comprises a monolithic coin or a core that may be plated with other metals.
US10472698B2
A brazed joint having excellent tensile strength (TSS and CTS) and a method of production of the same are provided. A sheet combination 200 comprised of steel sheets 210, 220 between which a brazing filler metal 230 is clamped is heated at a temperature of the Ac3 point of the steel sheet (matrix material) or more. The Ar3 point of the regions near the brazing filler metal at the steel sheets is made higher than the Ar3 point of the steel sheets (matrix material), then the quenching start temperature X is made a temperature of the Ar3 point of the steel sheet (matrix material) or less and hot stamping is performed to produce a brazed joint.
US10472680B2
Provided herein are methods and computer-readable storage media related to cell-free DNA and uses thereof to determine risk of a condition, such as transplant rejection or cancer, in a subject.
US10472675B2
Under one aspect, a device is provided for use in luminescent imaging. The device can include a photonic superlattice including a first material, the first material having a first refractive index. The first material can include first and second major surfaces and first and second pluralities of features defined through at least one of the first and second major surfaces, the features of the first plurality differing in at least one characteristic from the features of the second plurality. The photonic superlattice can support propagation of a first wavelength and a second wavelength approximately at a first angle out of the photonic superlattice, the first and second wavelengths being separated from one another by a first non-propagating wavelength that does not selectively propagate at the first angle out of the photonic superlattice.
US10472672B2
The invention relates to an automatic response/light measurement device and a method therefor, and the purpose is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size. The device is configured to have: a container group in which a plurality of reaction containers are arranged; a measurement mount provided with a plurality of coupling ends that are joinable with apertures of the reaction containers, and have light guide portions that optically connect with the interior of the joined reaction containers; a mount transfer mechanism; a measuring device having a measuring end having at least one light guide portion that is optically connectable to the light guide portions of the coupling ends, that is able to receive light based on an optical state within the reaction containers; an on-mount measuring end transfer mechanism; and a measurement control portion.
US10472651B2
In various embodiments, method and devices for delivering large cargos (e.g., organelles, chromosomes, bacteria, and the like) into cells are provided. In certain embodiments method of delivering a large cargo into eukaryotic cells, are provided that involve providing eukaryotic cells disposed on one side of a porous membrane; providing the cargo to be delivered in a solution disposed in a reservoir chamber on the opposite side of the porous membrane; and applying pressure to the reservoir chamber sufficient to pass the cargo through pores comprising said porous membrane wherein said cargo passes through cell membranes and into the cells.
US10472644B2
The present invention relates to protein expression in plants, particularly the large-scale production of recombinant polypeptides in whole Nicotiana tabacum plants. The use of preselected combination of N. tabacum varieties and Agrobacterium strains, optionally including one or more improvements to the transient expression-based methods of the invention, enables the production of large quantities of a heterologous polypeptides economically and in a short period of time.
US10472640B2
A method of real-time prognosis of a flooding phenomenon in a packed column includes steps as follows. An online data collection step is conducted, wherein a plurality of values of the pressure drop are collected from the packed column under operation. A calculation step is conducted, wherein the values of the pressure drop are used to calculate a plurality of values of a steadiness index. A statistical step is conducted, wherein a value of a monitoring statistic is calculated based on the values of the steadiness index. A control step is conducted, wherein the value of the monitoring statistic is compared to a control limit, and an alarm is triggered when the value of the monitoring statistic is greater than the control limit.
US10472637B2
Control Devices are disclosed including RNA destabilizing elements (RDE), RNA control devices, and destabilizing elements (DE) combined with Chimeric Antigen Receptors (CARs) or other transgenes in eukaryotic cells. Multicistronic vectors are also disclosed for use in engineering host eukaryotic cells with the CARs and transgenes under the control of the control devices. These control devices can be used to optimize expression of CARs in the eukaryotic cells so that, for example, effector function is optimized. CARs and transgene payloads can also be engineered into eukaryotic cells so that the transgene payload is expressed and delivered after stimulation of the CAR on the eukaryotic cell.
US10472627B2
Small interfering RNA (siRNA) knock down antisense transcripts, and regulate the expression of their sense partners. This regulation can either be discordant (antisense knockdown results in sense transcript elevation) or concordant (antisense knockdown results in concomitant sense transcript reduction).
US10472619B2
Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.
US10472613B2
The present invention relates to a method to modulate the level of activation of an engineered immune cell (such as a Chimeric Antigen Receptor T-cell) for immunotherapy. The present invention also relates to cells obtained by the present method, preferably comprising said modulable/tunable chimeric antigen receptors for use in therapeutic or prophylactic treatment.
US10472610B2
Provided is a method for generating pancreatic bud cells, having the step of culturing PDX1+/NKX6.1− cells in a medium containing KGF, EGF and a BMP inhibitor. The culturing step may be performed in suspension cultures or in adherent cultures. When the cells are cultured in adherent cultures, the cells may be cultured in a medium further containing a ROCK inhibitor or a nonmuscle myosin II inhibitor.
US10472607B2
The present invention discloses a culture medium and method for inducing differentiation of pluripotent stem cells into neuroepithelial cells. The culture medium comprises at least two agents for neural induction, wherein the agents includes a Wnt signal agonist and a Smad2/3 inhibitor and the culture medium is a feeder free culture. The method is to culture pluripotent stem cells in the culture medium to differentiate into neuroepithelial cells. The neuroepithelial cells can further differentiate into mature neurons for practical applications, including regeneration medicine and drug discovery for neural disorders.
US10472603B2
Systems, devices, and methods of the present disclosure assist with management of tubes and hoses during surgical procedures. The systems, devices, and methods provide for the proper opening and closing of tubes to facilitate performance of steps in a surgical procedure. Systems, devices, and methods of the present disclosure control fluid delivery to and from a medical device, including devices for tissue processing and cleaning.
US10472597B2
A multi-phase unit-dose cleaning product comprising: i) an amine-containing cleaning active selected from the group consisting of aminocarboxylic complexing agent, amine oxide surfactant and mixtures thereof; and ii) an oxidizing agent wherein at least 30% of the amine-containing cleaning active is in a different phase from the oxidizing agent.
US10472592B1
Embodiments of the present disclosure provide a system for purifying fats, oils, and grease from wastewater. The system may include a trash pump configured to pump the wastewater into the system, a grinder pump positioned downstream of the trash pump and configured to grind materials in the wastewater to form a process mixture, a plurality of heat exchangers positioned downstream of the grinder pump and configured to heat the process mixture, a shaker tray positioned downstream of the grinder pump and configured to remove solids from the process mixture, a decanter positioned downstream of the shaker tray and configured to remove solids from the process mixture, and a centrifuge positioned downstream of the decanter and configured to remove liquids and solids from the process mixture to form purified FOG.
US10472582B2
The invention is directed to a process and apparatus for removing hydrogen sulfide from a gas stream comprising biogas. In accordance with the invention the gas stream is contacted with an oxidizing agent present in a vessel, whereby said hydrogen sulfide is oxidized into elemental sulfur and said oxidizing agent is reduced, wherein oxygen containing gas is also fed to said vessel, wherein said oxygen oxidizes at least part of said reduced oxidizing agent.
US10472581B2
A process and apparatus for quenching a hydrocracked stream to prepare it for hydroisomerization. A fractionated hydroisomerized stream is recycled to quench a hot hydrocracked stream prior to hydroisomerization. Sufficient quenching can inactivate the hydroisomerization catalyst bed. The hydroisomerization catalyst bed can be heated back to hydroisomerization temperature and can actively hydroisomerize again.
US10472579B2
Process scheme configurations are disclosed that enable conversion of crude oil feeds with several processing units in an integrated manner into petrochemicals. The designs utilize minimum capital expenditures to prepare suitable feedstocks for the steam cracker complex. The integrated process for converting crude oil to petrochemical products including olefins and aromatics, and fuel products, includes mixed feed steam cracking and gas oil steam cracking. Feeds to the mixed feed steam cracker include light products and naphtha from hydroprocessing zones within the battery limits, recycle streams from the C3 and C4 olefins recovery steps, and raffinate from a pyrolysis gasoline aromatics extraction zone within the battery limits. Feeds to the gas oil steam cracker include unconverted oil intermediates from vacuum gas oil hydrotreating.
US10472564B2
The present invention discloses a delayed fluorescence compound and the organic electroluminescent device employing the delayed fluorescence compound as the delayed fluorescence dopant material, the delayed fluorescence host material, or the phosphorescent host material in the light emitting layer, and/or used in the hole blocking layer and/or the electron transporting layer of the organic EL device, which thereby displays good performance.
US10472562B2
A quantum dot-polymer micronized composite includes a first polymer matrix; a plurality of quantum dots dispersed in the first polymer matrix; and at least one of an additive selected from a clay particle embedded in the first polymer matrix and a metal halide dispersed in the first polymer matrix, wherein the quantum dot-polymer micronized composite has an average particle size of less than or equal to about 100 micrometers, a production method thereof, and an article and an electronic device including the micronized composite are provided.
US10472559B2
A method comprises obtaining or providing a treatment fluid comprising a gellable agent; an aqueous carrier fluid; at least one polymer comprising one or more ortho-dioxy arylene units; a crosslinking agent; and placing the treatment fluid in a subterranean formation. In some embodiments, the aqueous carrier fluid comprises produced and/or flowback water. In some embodiments, the aqueous carrier fluid comprises high total dissolved solids, including multivalent salts or both monovalent and multivalent salts.
US10472554B2
A cement for use in wells in which hydrogen sulfide is present, comprises polymer particles. In the event of cement-matrix failure, or bonding failure between the cement/casing interface or the cement/borehole-wall interface, the polymer particles swell when contacted by hydrogen sulfide. The swelling seals voids in the cement matrix, or along the bonding interfaces, thereby restoring zonal isolation.
US10472549B2
Creping adhesives can include one or more crosslinked resins having the chemical formula (O), (P), or (Q), where RX can be a crosslinking moiety, each RY can independently be a substituted or unsubstituted organic diyl moiety, and each A− can independently be an anion. The creping adhesive can have a cylinder probe adhesion of about 100 gram-force to about 300 gram-force. The creping adhesive can have a peel adhesion of about 20 g/cm to about 110 g/cm.
US10472548B2
Thermosetting resin compositions are provided that are useful for mounting onto a circuit board semiconductor devices, such as chip size or chip scale packages (“CSPs”), ball grid arrays (“BGAs”), land grid arrays (“LGAs”) and the like (collectively, “subcomponents”), or semiconductor chips. Reaction products of the compositions are controllably reworkable when subjected to appropriate conditions.
US10472532B2
The present invention relates to a magenta ink for inkjet recording containing at least one pigment selected from the group consisting of C.I. Pigment Red 147, 150, 176, 266 and 269, in an amount of 0.5 to 10% by mass relative to the total mass of the ink. The present invention can provide a magenta ink that is comprehensively superior in terms of light resistance, color development and storage stability. The present invention can also provide an ink set having excellent light resistance and color development for each ink included in the ink set, and an inkjet recording method that uses the ink set.
US10472531B2
The present disclosure relates to an ink composition containing a colorant; a hydroxylated co-solvent; a non-hydroxylated co-solvent, a polyurethane binder and water. The weight percent ratio of the hydroxylated co-solvent to the non-hydroxylated co-solvent in the ink composition ranges from 55:45 to 65:35; and the total amount of hydroxylated co-solvent and non-hydroxylated co-solvent in the ink composition is at least 18 wt %. The amount of polyurethane binder in the ink composition is 0.1 to less than 1 wt %.
US10472525B2
Use of dithiophosphinic acids of the general formula HS2P(R1)(R2) and/or salts thereof for producing chrome-free, polymer-containing corrosion control layers on metallic surfaces, R1 and R2 independently of one another each being organic radicals having 1 to 30 C atoms.
US10472524B2
The present disclosure provides an aqueous binder composition for forming a sacrificial corrosion-protective coating, said composition being free of chromates and also preferably free of borates and molybdates. Said binder composition advantageously has a pH of less than 6 and comprises a binder, particles of at least one metal oxide and at least one metallic phosphate, said binder comprising a hydrolyzed organosilane oligomer. In addition, the proportion by weight of said particles of at least one metal oxide relative to the total dry weight of said binder composition is greater than or equal to 75%.
US10472518B2
Provided is a method of producing a polycarbonate-polyorganosiloxane copolymer, including a step (Q) of causing a polycarbonate oligomer and at least one of polyorganosiloxanes represented by the following general formulae (i) to (iii) to react with each other in an organic solvent, in which in the step, a solid content weight x (g/L) of the polycarbonate oligomer in 1 L of a mixed solution of the organic solvent and the polycarbonate oligomer, a concentration y (mass %) of the polyorganosiloxane in the polycarbonate-polyorganosiloxane copolymer to be obtained, and a chain length n of the polyorganosiloxane satisfy specific conditions.
US10472514B2
A block copolymer composition including: 10% by mass or more and 90% by mass or less of a component (a), and 10% by mass or more and 90% by mass or less of a component (b), wherein the component (a) is a block copolymer containing a polymer block (A) primarily including a vinyl aromatic monomer unit and a polymer block (B) primarily including a conjugated diene monomer unit, wherein the block copolymer has a weight average molecular weight of 30,000 or higher and 150,000 or lower; and the component (b) is a block copolymer containing a polymer block (A) primarily including a vinyl aromatic monomer unit and a polymer block (B) primarily including a conjugated diene monomer unit.
US10472513B2
The present disclosure provides a composition. In an embodiment, the composition includes A) an ethylene/acrylate interpolymer or an ethylene/acetate interpolymer; B) an ethylene/α-olefin multi-block copolymer; and C) a flame retardant. In an embodiment, the ethylene/acrylate interpolymer is a functionalized ethylene/acrylate interpolymer. The present composition exhibits improved dirt pick-up resistance.
US10472509B2
The present invention is directed to a heterophasic propylene copolymer (HECO), a polyolefin composition (PO) comprising the heterophasic propylene copolymer (HECO), an automotive article comprising the heterophasic propylene copolymer (HECO) and/or the polyolefin composition (PO) and a process for the preparation of the polyolefin composition (PO) as well as the use of the heterophasic propylene copolymer (HECO) for improving the mechanical properties of a polyolefin composition (PO).
US10472500B2
The present disclosure generally relates chitosan-based biopolymers and chitosan biopolymer film based triboelectric nanogenerators generating voltage and current using the triboelectric effect. The chitosan-based biopolymer is a reaction product of at least a chitosan and an acid, and optionally one or more component selected from starch, lignin and/or glycerol.
US10472481B2
The present invention relates to a method for preparing a functional extract-containing polyvinyl alcohol film, which has an improved specific surface area by having a wrinkled form, and specifically, to a method for preparing a functional extract-containing polyvinyl alcohol film having wrinkles formed on a surface thereof, which comprises saponifying a functional extract-containing polyvinyl acetate film, while the functional extract-containing polyvinyl acetate film is immersed in a first solvent capable of maintaining the film form of the functional extract-containing polyvinyl acetate film, so as to convert the functional extract-containing polyvinyl acetate film into a functional extract-containing polyvinyl alcohol film.
US10472477B2
Provided are a polycarbonate resin composition for a thin optical component that has a high transmittance and a good hue, and a thin optical component. The polycarbonate resin composition for a thin optical component contains, per 100 mass parts of a polycarbonate resin (A), 0.1 to 4 mass parts of a polyalkylene glycol copolymer (B) having a linear alkylene ether unit (B1) given by general formula (I) and a branched alkylene ether unit (B2) selected from units given by general formulas (II-1) to (II-4), and 0.005 to 0.5 mass parts of a phosphorus stabilizer (C).
US10472465B2
The present invention relates to a method for producing a polycarbonate diol, comprising subjecting a compound represented by the following formula (A) containing from 0.01 to 1.0 wt % of an aldehyde derivative, a compound represented by the following formula (B), and a carbonate compound to polycondensation by a transesterification reaction in the presence of a catalyst to produce a polycarbonate diol having a number average molecular weight of 250 to 5,000: HO—(CH2)10—OH (A) HO—R1—OH (B) wherein in the formula (B), R1 represents a substituted or unsubstituted divalent alkylene group having a carbon number of 3 to 20, wherein the compound of the formula (A) is not included by the formula (B).
US10472464B2
A method for producing a polyester includes: a) preparing a first monomer represented by Formula (1) for example—bis(β-hydroxyethyl) terephthalate (BHET); and b) preparing a second monomer represented by Formula (2) represented by Formula (2)—2-(2-hydroxyethoxy)ethyl 2-hydroxyethyl terephthalate (BHEET). The prepared first and second monomer are then mixed to form a mixture, and then the mixture is subjected to a pre-polymerization reaction at a first temperature not higher than 230° C. to form a prepolymer while a glycol compound represented by Formula (3) wherein R independently represents hydrogen, a C1-C6 linear or branched alkyl group, or phenyl; is continuously removed by distillation. The method also includes subjecting the prepolymer to a polymerization reaction at a second temperature higher than the first temperature to obtain the polyester.
US10472457B2
In various embodiments, the present invention is directed to new low cost initiator compositions for use with the production of well-defined telechelic PIBs (by LC+P of isobutylene). In various other embodiments, the present invention is directed to methods for using these novel compositions as initiators for isobutylene (IB) and other cationically polymerizable monomers, such as styrene and its derivatives. In still other embodiments, the present invention is directed to structurally new, allyl (and chlorine) telechelic PIBs formed from these new initiator compositions and their derivatives (in particular, hydroxyl telechelic PIB and amine telechelic PIB). In yet other embodiments, the present invention is directed to structurally new polyurethanes, polyureas, and polyurethane ureas made using telechelic PIBs formed from these new initiator compositions.
US10472453B2
1) Specific polyurethane prepolymer (PP2) comprising at least two terminal (2-oxo-1,3-dioxolan-4-yl)methyl carbamate groups of low viscosity, its preparation process and its use in the manufacture of an adhesive composition.2) Multicomponent system comprising, as first component (A), a composition comprising at least one such polyurethane prepolymer and, as second component (B), a composition comprising at least one curing agent comprising at least two primary amine (—NH2) groups (B1).3) Process for assembling materials employing the polyurethane prepolymer (PP2) according to the invention.
US10472450B2
A compound made by copolymerizing a poly(N-isopropylacrylamide) chain transfer agent, an acrylate salt, and a polyethylene glycol diacrylate. A compound made by copolymerizing a polyethylene glycol, a glycerol ethoxylate, and an aliphatic diisocyanate.
US10472442B2
The invention relates to a specific copolymer obtainable by co-polymerizing at least the following monomers: —more than 80 wt % of at least one bicyclic (meth)acrylate ester, —0.05 to 15% w/w styrene, and —optionally other ethylenically unsaturated monomers, as well as to the way to synthesize them and the use of such polymers to modify the rheology of a liquid in which they are soluble.
US10472437B2
Disclosed is an article comprising polymers and copolymers selected from the group consisting of poly(vinylbiphenyl), poly(vinylcyclohexylstyrene), substituted versions thereof, and blends thereof, the polymer or copolymer having a weight average molecular weight (Mw) of at least 100 kg/mole and a glass transition temperature (Tg) of at least 100° C. The polymers are desirably processed in the melted state at a temperature of at least 150° C. to impart orientation and extensional strain hardening.
US10472434B2
The present invention is directed to a stereoregular functionalized elastomer represented by poly(M1 co M2), wherein the functionalized elastomer comprises a microstructure selected from the group consisting of microstructures having at least 90 percent by weight of monomer residues in trans 1,4-configuration, and microstructures having at least 80 percent by weight of monomer residues in cis 1,4-configuration; wherein M1 is selected from the group consisting of isoprene and 1,3-butadiene; and M2 is of formula 4 wherein R6 is a covalent bond, phenylene, a linear or branched alkane diyl group containing 1 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing 1 to 10 carbon atoms; R7 is hydrogen or a linear or branched alkyl group containing 1 to 10 carbon atoms; X1 is selected from formulas 5 and 6 wherein R8 and R9 are independently trialkylsilyl, phenyl or a linear or branched alkyl group containing 1 to 10 carbon atoms, or one of R8 and R9 is hydrogen and the other is phenyl or a linear or branched alkyl group containing 1 to 10 carbon atoms, or R8 and R9 taken together with the nitrogen atom represent a nitrogen containing heterocyclic group containing from 4 to 12 carbon atoms; and X2 is a sulfur atom or a structure of formula 7 or 8 wherein when X2 is of formula 8, the S atom of formula 8 is adjacent to the phenyl ring of formula 6 and the N atom of formula 8 is adjacent to R6.
US10472429B2
A method according to the present invention for producing water absorbent resin powder is a method for producing water absorbent resin having a surface cross-linked structure, and includes: a polymerization step in which an unsaturated monomer aqueous solution is polymerized; a drying step in which a hydrogel cross-linked polymer obtained in the polymerization step is dried; a surface treatment step in which the hydrogel cross-linked polymer or a dried hydrogel cross-linked polymer is subjected to a surface treatment; and a sorting step, carried out after the drying step, in which a foreign matter included in a water absorbent resin is color-sorted from the water absorbent resin entirely or partially. As a result, it is possible to obtain a water absorbent resin which has high properties and is less likely to be colored. In this way, there is provided the water absorbent resin powder production method in which the color sorting technique is used to remove foreign matters from the water absorbent resin.
US10472426B2
The present disclosure provides a binding protein comprising: a polypeptide heavy chain comprising: VH1-(X1)n-VH2—CH (X2)y wherein VH1 is a first variable domain, VH2 is a second variable domain, CH is a constant domain, X1 represents an amino acid or peptide, X2 represents an Fc region, n is 0 or 1 and y is independently 1 or 2, and a polypeptide light chain comprising: VL1-(X1)n-VL2-C wherein VL1 is a first variable domain, VL2 is a second variable domain, C is a constant domain, X1 represents an amino acid or peptide and n is 0 or 1, wherein the heavy chain and light chain are aligned such that VH1 and VL1 form a first binding domain, and VH2 and VL2 form a second binding domain and wherein: there is a disulfide bond between VH1 and VL1, and/or there is a disulfide bond between VH2 and VL2, and use thereof in treatment.
US10472414B2
The present invention relates to antibodies specific for pyroglutamated Aβ, as well as their use in the treatment of Alzheimer's disease and as use in diagnostic methods or as diagnostic imaging ligands. Further, is provided pyroglutamated N-terminal fragments of murine or human Aβ to generate antibodies and for use in therapeutic purposes.
US10472404B2
The present invention relates to the field of biopharmaceuticals, and in particular to a protein, a protein conjugate, a pharmaceutical composition and its use for treating diabetes. The fusion protein of the present invention is obtained by linking two polypeptides, wherein one polypeptide is an interleukin-1 receptor antagonistic protein or an analogue thereof, and another polypeptide is GLP-1 receptor binding polypeptide or an analogue thereof, or an insulin receptor binding polypeptide or an analogue thereof, or a GIP receptor binding polypeptide or an analogue thereof. The fusion proteins of the present invention and conjugates thereof have a significant efficacy in treating diabetes, and can be used in a lower dose, resulting in marked reduction in side effects.
US10472398B2
The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
US10472391B2
Certain embodiments are directed to compositions and methods of inhibiting a pathogenic bacterial infection involving ADAM10, specifically a method for treating pore-forming toxin-inducted pathology caused by exposure to staphylococcus in a subject, comprising administering an effective amount of a ADAM10 inhibitor to a patient. The methods include treating pneumonia or inhibiting disruption to epithelial barrier in a subject, having or at risk of developing staphylococcal infection.
US10472385B2
Suggested are triterpene-glycoside compounds, which are obtainable by the extraction of Momordica grosvenorii (Siraitia grosvenori) which are useful as a sweetener or sweetener enhancer in preparations and compositions, especially oral edible compositions.
US10472383B2
This invention claims aqueous compositions that comprise triphosphates of 2′-deoxynucleoside derivatives that have, instead of a 3′-OH moiety, a 3′-ONH2 moiety; wherein said compositions contain less than 0.5 mole percent contaminating triphosphate having a 3′-OH moiety, as well as processes for providing such compositions. The compositions further must contain insubstantial amounts of hydroxylamine.
US10472379B2
The described invention provides a compound comprising an organometallic complex comprising a core of ruthenium and sphingomyelin, with the option of added zinc, that, in a therapeutic amount, through further connections with contributing organic ligands, are effective as chemotherapeutic agents that have an anti-tumor or anti-cancer effect on a tumor comprising tumor cells including a cytotoxic effect on of the tumor cells, inhibition of the growth of the tumor comprising the tumor cells, inhibition of migration of the tumor cells, or any combination of these effects.
US10472377B2
A method for producing a narrowly distributed and high-purity polyalkylene glycol derivative having an amino group at an end, a polymerization initiator for use in the method, and a precursor of the polymerization initiator are provided.The present invention provides: a method for producing a polyalkylene glycol derivative having an amino group at an end, using, as a polymerization initiator, a compound represented by the general formula (I); a compound represented by the following general formula (I); and a precursor thereof: wherein RA1a and RA1b each independently represent a protective group of the amino group, or one of RA1a and RA1b represents H and the other represents a protective group of the amino group, or RA1a and RA1b bind to each other to represent a cyclic protective group forming a ring; RA2 represents a linear, branched, or cyclic hydrocarbon group having 1 to 6 carbon atoms; RA3 represents a single bond, or a linear, branched, or cyclic hydrocarbon group having 1 to 20 carbon atoms, and the hydrocarbon group may contain a heteroatom; the total number of carbon atoms (or the total number of carbon atoms and heteroatoms) of RA2 and RA3 is 4 or more; and M represents an alkali metal.
US10472371B2
Compositions for the activation of PKR are provided, as well as therapeutic administration of the compositions for the treatment of pyruvate kinase-related medical conditions, such as pyruvate kinase deficiency (PKD).
US10472367B2
The present invention relates to imidazo[1,2-b][1,2,4]triazines that are inhibitors of c-Met and are useful in the treatment of c-Met associated diseases including cancer.
US10472366B2
The invention relates to glucuronide prodrug compounds of the Janus kinase (JAK) inhibitor tofacitinib having formula I: where A1 and R1 are as defined. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds to treat gastrointestinal inflammatory diseases; and processes and intermediates for preparing such compounds.
US10472360B2
The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
US10472359B2
Pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl) butan-1-one for inhibiting serotonin reuptake transporter activity
The invention relates to pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one in toluenesulfonic acid addition salt form: and methods of use in the treatment of diseases involving the 5-HT2A receptor pathway, the serotonin transporter (SERT) pathway and/or the dopamine D2 receptor pathway signaling systems.
US10472358B2
The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.
US10472357B2
The invention relates to a compound of Formula I or IA and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof:
US10472356B2
The present invention provides compounds of Formula (I), wherein: as defined in the specification, an enantiomer, diastereomer, atropisomer thereof, or a mixture thereof, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
US10472355B2
An SP-141 compound is a novel small molecule that can serve as a molecular-targeted chemotherapeutic agent. In one embodiment, the labeled compound can comprise SP-141, which comprises 6-methoxy-1-(naphthalen-1-yl)-9 H-pyrido[3,4-b]indote. The compound inhibits expression of oncogenes such as the Mouse Double Minute 2 protein. The compound can bind directly to Mouse Double Minute 2 to inhibit cancer growth including breast cancer growth.
US10472350B2
The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.
US10472349B2
A mesylate salt of the compound of formula (I), the preparation method thereof, a pharmaceutical composition containing said salt and the use of said salt in treating diseases mediated by activating and resistance mutations of EGFR, in particular cancers, in mammal, in particular human. The mesylate salt of the compound of formula (I) has a high bioavailability in animal, and can remarkably inhibit the growth of transplanted tumors in animal and show a good safety.
US10472346B2
Provided herein are compounds and methods for treating a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease. Provided herein are compositions and methods for treating a disorder associated with aberrant Aβ peptide levels, including AD. Provided herein are compounds of Formula (A) or a pharmaceutically acceptable salt thereof, wherein, L′ is selected from the group consisting of C(O), C(R1)(R2), substituted or unsubstituted —C2-6 alkylene-, and substituted or unsubstituted —C3-6 cycloalkylene.
US10472342B2
The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
US10472338B2
Provided is a method for producing flutemetamol including the steps of: reacting a precursor compound represented by a predetermined general formula with a radioactive fluoride to obtain a 18F labeling compound represented by a predetermined general formula; allowing a strong base to act on the reaction mixture of the above step containing the precursor compound and the 18F labeling compound; after the above step, purifying the 18F labeling compound using a reverse phase solid phase extraction cartridge; and removing a protective group to obtain [18F]flutemetamol.
US10472334B2
Compounds suitable for use in providing male contraception, an assay method for identifying such compounds, and methods of providing contraception using the compounds, are provided. In one embodiment, the compounds described herein mimic the binding of anti-EPPIN antibodies to EPPIN, and thus inhibit the forward motility of sperm in humans and other primates. In another embodiment, the compounds described herein inhibit or enhance EPPIN-semenogelin binding, and inhibit forward motility of sperm. The assays described herein identify compounds which inhibit sperm motility, and can be carried out in a high throughput manner, using labeled recombinant EPPIN and semenogelin. The compounds can be used in oral or transdermal compositions to temporarily and reversibly inhibit male fertility. They can also be used in addition to, or in place of, spermicides in spermicidal compositions, such as those used in conjunction with condoms, diaphragms, and spermicidal jellies.
US10472333B2
Compounds represented by the following general formula (I), which has a P2X4 receptor antagonistic activity (in the formula, R1, R2 and R3 represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, and the like, X represents C or N, Y represents N or C(═O), provided that when X is C, Y represents N, and when X is N, Y represents C(═O), the double line consisting of the solid line and the broken line represents a single bond or double bond, n represents an integer of 0 to 6, Z represents O, S, or an atomic bond, and A represents benzene ring, pyridine ring, and the like).
US10472324B2
A compound of the formula (I) or a tautomeric isoform thereof wherein R1 is selected from the group consisting of halogen, nitro, lower alkyl sulfonyl, cyano, trifluromethyl lower alkyl, lower alkoxy, lower alkoxycarbonyl, carboxy, lower alkyl aminosulfonyl, perfluoro lower alkyl, lower alkylthio, hydroxy lower alkyl, alkoxy lower alkyl, lower alkylthio lower alkyl, lower alkylsulfinyl lower alkyl, lower alkylsulfonyl lower alkyl, lower alkylsulfonyl, lower alkanoyl, aroyl, aryl, aryloxy and R2 is selected from the group consisting of hydrogen, alkyl, alkoxy, alkylthio, and alkylcarbonyl, and their non-toxic, pharmaceutically acceptable base addition salts or pro-drugs thereof. The compounds of the invention are useful in the treatment of nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex.
US10472313B1
A process for synthesizing trifluoroketones, such as 1-(5-chloro[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone.
US10472310B2
Continuous processes for making propylene glycol from ketose-yielding carbohydrates are disclosed which enhance the selectivity to propylene glycol.
US10472309B2
The present invention provides a composition comprising an HFO compound, the composition having excellent stability with decomposition and oxidation of the HFO compound being inhibited, the composition having improved refrigerating capacity when used as a heat transfer medium, compared with the case in which an HFO compound is used alone. More specifically, the present invention provides a composition comprising at least one HFO compound selected from the group consisting of HFO-1234yf, (E-/Z-)HFO-1234ze, and (E-/Z-)HFO-1225ye; and a chlorine-containing compound, wherein (1) the chlorine-containing compound is at least one member selected from the group consisting of CH2═CHCl, CHF═CHCl, CH2═CFCl, CF3Cl, CH3Cl, CF3CH2Cl, CClF═CHCl, and CHF═CCl2, and (2) the chlorine-containing compound is contained in an amount ranging from 1 to 500000 mass ppm.
US10472307B2
Provided is a method for producing (Z)-1-chloro-2,3,3-trifluoro-1-propene where (E)-1-chloro-2,3,3-trifluoro-1-propene and water can be efficiently removed and (Z)-1-chloro-2,3,3-trifluoro-1-propene with higher purity can be obtained at a higher recovery ratio. The method for producing (Z)-1-chloro-2,3,3-trifluoro-1-propene includes: distilling a distillation composition which contains (Z)-1-chloro-2,3,3-trifluoro-1-propene, (E)-1-chloro-2,3,3-trifluoro-1-propene and water to remove (E)-1-chloro-2,3,3-trifluoro-1-propene and water as an azeotropic composition or an azeotropic-like composition.
US10472297B2
A method and system is provided for using biochar in composting environments to control temperature, moisture, acid and pH levels, odors and bacterial cultures. The method further includes treating the biochar prior to combining it with the compost to further control such parameters.
US10472283B2
A comb polymer is used for increasing the flow rate and/or reducing the viscosity of a mineral binder composition, where the comb polymer has a main chain including acid groups and there are pendent chains linked to the main chain, and where the average number-average molar mass of all of the pendent chains is from 120 to 1000 g/mol and the molar ratio of the acid groups to the side chains is in the range from 0.5 to 2.
US10472281B2
Polyurethane composites and methods of preparing polyurethane composites are described herein. The polyurethane composite can comprise (a) a polyurethane formed by the reaction of (i) one or more isocyanates selected from the group consisting of diisocyanates, polyisocyanates, and mixtures thereof, and (ii) one or more polyols; (b) fly ash comprising 50% or greater by weight, fly ash particles having a particle size of from 0.2 micron to 100 microns; and (c) a coarse filler material comprising 80% or greater by weight, filler particles having a particle size of from greater than 250 microns to 10 mm. The coarse filler material can be present in the composite in an amount of from 1% to 40% by weight, based on the total weight of the composite. The weight ratio of the fly ash to the coarse filler material can be from 9:1 to 200:1.