The invention relates to a preparation method of quinoline derivative, which mainly comprises the following steps: with the existence of a rare earth catalyst, substitutional aniline reacts with an Alpha, Beta unsaturated aldehyde, ketone or esters compound so as to obtain a target compound. The preparation method has the advantages of being simple and quick in synthetic procedures, mild in synthetic condition, low in synthetic cost, higher in synthetic yield, and applicable to multiple reaction substrates, etc.