The invention relates to a method for removing non-metal foreign substances from pipeline steel. The method comprises the steps that: tapping is carried out after top and bottom combined blowing converter smelting; molten steel is sequentially subjected to LF furnace refining, calcium treatment, and primary soft-blowing stirring; RH vacuum refining and secondary soft-blowing stirring are carried out; and full-protection casting is carried out. According to the method provided by the invention for removing non-metal foreign substances from pipeline steel, ladle top slag composition is controlled during the refining process; the calcium treatment and the primary soft-blowing are carried out after LF furnace refining is finished, such that the conversion from high-melting-point foreign substances to low-melting-point calcium aluminate is promoted; secondary soft-blowing is carried out after RH vacuum refining, such that low-melting-point non-metal foreign substances floating is further promoted. Therefore, a problem of excessive B-type foreign substances in high-grade pipeline steel can be solved.