The invention discloses a manufacturing method of a super-large-diameter large-wall thick longitudinal submerged arc welded pipe. The super-large-diameter large-wall thick longitudinal submerged arc welded pipe is made of X80 hot-rolled stated steel plates according with the API5L-2007 (44 version) standard of the American petroleum institute in chemical composition percentage, and a microscopic structure of the super-large-diameter large-wall thick longitudinal submerged arc welded pipe is an AF+B organization. The manufacturing method of the super-large-diameter large-wall thick longitudinal submerged arc welded pipe comprises the following steps: automatic flaw detection of a steel plate, edge preparation, pre-springing, molding, pre-welding, inner welding and outer welding, a first ultrasonic wave automatic inspection, a first X-ray inspection, mechanical hole enlargement, pipe end processing, hydrostatic testing, edge preparation, a second ultrasonic inspection, a second X-ray inspection, a second pipe end ultrasonic manual inspection, an external dimension inspection, postweld heat treatment, an appearance inspection and anticorrosive coating. The manufacturing method of the super-large-diameter large-wall thick longitudinal submerged arc welded pipe has the advantages of solving various technical problems of the production of the super-large-diameter large-wall thick longitudinal submerged arc welded pipe through strict technical controlling of working procedures, and enabling performances of a produced steel pipe to completely meet the requirement of a national standard.