The invention relates to hydroxyphenyl benzyl ether derivative as well as a preparation method and an application thereof. Part of a compound is marked by radionuclide and is used as an Abeta plaque imaging agent, and the hydroxyphenyl benzyl ether derivative is applied to the preparation of a drug for diagnosis and treatment of the allzheimer's disease. The structural formula of the hydroxyphenyl benzyl ether derivative is described in a formula (I). The chemical structure of the class of bran-new hydroxyphenyl benzyl ether derivatives with the high affinity with Abeta plaques inside an AD disease brain is different from a compound disclosed by the prior art, and the hydroxyphenyl benzyl ether derivative belongs a bran-new compound for the diagnosis and the treatment of the allzheimer's disease. The obtained Abeta plaque imaging agent is good in in-vivo stability, low in lipid solubility, and high in brain cleaning speed, does not generate the problem of the radionuclide removed in an in-vivo manner, and has great application values and market values.