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发明公开
CN104774231A 17α-羟基-19-去甲孕甾-4，9-二烯-3,20-二酮的制备工艺 无效 - 驳回

17α-羟基-19-去甲孕甾-4，9-二烯-3,20-二酮的制备工艺
摘要：
本发明提供了17α‐羟基‐19‐去甲孕甾‐4,9‐二烯‐3,20‐二酮的制备工艺，包括以下步骤：将反应底物2加入到无水混合溶剂中，再加入甲基格式试剂，在适当温度下反应一段时间后，检测所述反应底物反应完全后，再将得到的中间产物在酸性条件下水解反应完全，反应混合物后处理得到17α‐羟基‐19‐去甲孕甾‐4,9‐二烯‐3,20‐二酮，反应式为：该工艺具有如下优点：避免较苛刻的反应条件，且收率高达88.5%；条件温和，容易操作，易于放大，适合工业化生产。
摘要（英）：

The present invention provides a 17alpha-hydroxy-19-norpregn-4,9-diene-3,20-dione preparation process, which comprises: adding a reaction substrate 2 to an anhydrous mixing solvent, adding a methyl Grignard reagent, reacting for a certain time at a suitable temperature, carrying out a complete hydrolysis reaction on the obtained intermediate product under an acid condition after the reaction substrate completely reacts, and treating the reaction mixture to obtain the 17alpha-hydroxy-19-norpregn-4,9-diene-3,20-dione, wherein the reaction formula is defined in the instruction. The process of the present invention has advantages of avoidance of harsh reaction condition, high yield up to 88.5%, mild conditions, easy operation, and easy scale-up, and is suitable for industrial production.

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