The invention discloses a real-time prediction method of food safety on the basis of association rule mining, and belongs to the field of food safety. The real-time prediction method comprises the following steps: firstly, using a mining method based on an association rule to find other food associated with problem food and relevancy between the problem food and other food; then, according to a food risk index system, measuring weight values and risk coefficients which affect the risk factors of the associated food; and finally, according to the weight values and the risk coefficients of the risk factors, calculating the risk values of the associated food. The method can find other food associated with the safety of certain problem food, can measure the frequencies of various risk factors which cause the certain food to generate a safety problem in a historical database to automatically regulate the weights of the risk factors which affect the food safety so as to calculate the comprehensive influence, i.e. a food safety degree, on the certain food by all risk factors, provides a food safety reference for consumers and provides a decision basis for decision makers.