The present invention provides a single event transient resistant differential driver applicable to an FPGA for space flight. The single event resistant transient differential driver is used to generate a differential signal that meets differential standards such as LVDS25/LVDS33/LVDS25EXT/LVDS33EXT/LDT. The differential driver has single event transient resisting capability, and can be embedded in an IO interface circuit of the FPGA for space flight to be used in a radiation environment in the space. A filter circuit is disposed on a bias voltage path, and a filter circuit capable of being programmably controlled by a user is disposed on an output data path, so that transient voltage fluctuation caused by a single event effect can be effectively prevented from spreading on the two paths, and an effect on a final output differential signal is eliminated, and an identification error of a subsequent receiving circuit and a data transmission error are avoided.