The invention provides a preparation method for a biaryl compound. The preparation method comprises the step of performing cross coupling reaction on a substrate A and an organic zinc reagent B under a catalytic effect of a catalyst, thereby acquiring the biaryl compound, wherein a chemical structure of the substrate A is shown in the description; the organic zinc reagent B has the chemical structure shown in the description; and the catalyst is one or more of nickel salt, copper salt and cobalt salt. Compared with the other noble metal catalysts, such as, metal palladium catalyst, the catalyst adopting nickel salt, copper salt or cobalt salt is low in cost, so that the reaction cost of the biaryl compound is greatly reduced. Meanwhile, the aryl sulphonate or aryl halide shown as the substrate A has an excellent electrophilic property, is an electrophilic reagent with an excellent property and has the advantages of easiness in preparation, low cost, high activity and high stability. The substrate A and the organic zinc reagent B have cross coupling reaction under the effect of nickel salt, copper salt or cobalt salt so as to generate the biaryl compound and the reaction yield is higher.