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发明公开
CN109022437A 一种抑制山羊副流感病毒3型复制的靶标位点序列及其应用 有权

一种抑制山羊副流感病毒3型复制的靶标位点序列及其应用
摘要：
本发明涉及一种抑制山羊副流感病毒3型（CPIV3）复制的靶标位点序列及其在制备抗山羊副流感病毒3型药物中的应用。所述抑制山羊副流感病毒3型复制的靶标位点序列位于干扰素调节基因2（IRF2）的3’UTR中，其核苷酸序列如SEQ ID NO:19所示，受bta‑miR‑222序列直接靶定，从而降解IRF2的mRNA，降低IRF2蛋白的表达量，提高Ⅰ型干扰素表达水平，抑制CPIV3增殖。该靶标位点序列为研发新的治疗因CPIV3引发的疾病的抗病毒药物提供了一个新的药物靶点。此外还可应用于评价bta‑miR‑222调节IRF2转录水平，以及培育抗山羊副流感病毒3型转基因羊方面。
摘要（英）：

The invention relates to a target site sequence for inhibiting replication of goat parainfluenza virus type 3 (CPIV3) and its application in preparing anti-goat parainfluenza virus type 3 medicine. The target site sequence for inhibition of goat parainfluenza virus type 3 replication is located in the 3' UTR of interferon regulatory gene 2 (IRF2), the nucleotide sequence of which is shown as SEQ ID NO: 19. The sequence is directly targeted by the bta-miR-222 sequence, thereby degrading the mRNA of IRF2, decreasing the expression of IRF2 protein, increasing the expression level of type I interferon, and inhibiting the proliferation of CPIV3.The target site provides a new drug target for the development of new antiviral drugs for the treatment of diseases caused by CPIV3. It can also be usedto evaluate IRF2 transcription levels regulated by bta-miR-222, as well as to breed anti-goat parainfluenza virus type 3 transgenic sheep.

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