The invention discloses a 3-cyanophenoxyalkyl aryl piperazine derivative and applications in the preparation of drugs. The 3-cyanophenoxyalkyl aryl piperazine derivative shows the effect on central nervous systems, especially on 5-HT<1A> receptor selective high affinity interaction, but has no obvious affinity interaction on dopamine D1 and D2 receptors, adrenergic receptor alpha 1 and alpha 2, SERT (5-HT transporter protein), NET (adrenergic transporter protein), DAT (dopamine transporter protein) and other central related receptors and proteins. Various physiological and pharmacological effects are brought into play in the body; and the compound can be used as a pharmaceutical active substance, especially used for diseases like anti-depression, anti-anxiety and anti-neuropathic pain, andcan also be used as an intermediate to prepare other pharmaceutical active compounds. The compound is fast in effect and small in toxic and side effect, and can meet demands of clinical applications;and the compound is a compound having the following structural formula or a free base or salt thereof. The structure of the compound is shown in the description.