The present invention provides a method and a system for driving hybrid vehicle. The method for driving a hybrid vehicle includes the steps of: determining, by a transmission controller, whether the hybrid vehicle is driven in a sensorless control mode or not, wherein in a sensorless control mode in which an estimated rotor position value determined based on electric current and voltage of a drivemotor is used to control the drive motor, without using information detected by a stator position sensor provided in the drive motor of the hybrid vehicle, a transmission is used to enable the drivemotor to operate in an area in which the precision of a sensorless control is high.