The utility model discloses a compound three-layer tablet for treating helicobacter pylori. A first antibiotic layer (1), a proton pump preparation layer (2) and a second antibiotic layer (3) form an upper layer structure, a middle layer structure and a lower layer structure of the tablet; the three-layer tablet is directly coated with a film coating layer (4); a proton pump preparation is arranged in the middle of the three-layer tablet; and antibiotics are arranged at two sides of the three-layer tablet. Active medicinal components in the compound three-layer tablet can be simultaneously dissolved out, so that the dose is easy to control. In addition, the tablet is smooth and attractive in appearance and is easy to take, and thus the medicine-taking compliance of a patient is enhanced.