发明公开
- 专利标题： THIOL SULFONE METALLOPROTEASE INHIBITORS
- 专利标题（中）： 巯砜ALS金属蛋白酶
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申请号： EP97936169申请日： 1997-07-22
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公开(公告)号： EP0939628A4公开(公告)日： 1999-12-22
- 发明人: FRESKOS JOHN N , ABBAS ZAHEER S , DECRESCENZO GARY A , GETMAN DANIEL P , HEINTZ ROBERT M , MISCHKE BRENT V , MCDONALD JOSEPH J
- 申请人： MONSANTO CO
- 专利权人： MONSANTO CO
- 当前专利权人： MONSANTO CO
- 优先权： US2204396 1996-07-22
- 主分类号： C07D295/08
- IPC分类号： C07D295/08 ; A61K31/10 ; A61K31/165 ; A61K31/17 ; A61K31/192 ; A61K31/216 ; A61K31/22 ; A61K31/27 ; A61K31/4164 ; A61K31/426 ; A61K31/4402 ; A61K31/4406 ; A61K31/4409 ; A61K31/5375 ; A61K31/5377 ; A61P43/00 ; C07C317/22 ; C07C317/32 ; C07C323/65 ; C07C327/22 ; C07C327/24 ; C07C327/26 ; C07C327/28 ; C07C327/32 ; C07D213/34 ; C07D213/70 ; C07D233/84 ; C07D277/20 ; C07D277/36 ; C07D295/12 ; A61K31/19 ; A61K31/215 ; A61K31/40 ; A61K31/415 ; A61K31/425 ; A61K31/44 ; A61K31/535 ; C07C237/20
摘要：
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.
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