公开(公告)号：EP3877362A1

公开(公告)日：2021-09-15

申请号：EP19798382.8

申请日：2019-11-04

Applicant: Mariposa Therapeutics Ltd.

Inventor： RAO, Kodanda Ranganatha Nagaraja ,  NEWTON, Christopher Gregory ,  EVANS, Gareth James Street

IPC: C07C323/65 ,  C07D307/38 ,  C07D333/18 ,  A61K31/105 ,  A61P29/00 ,  A61P31/04

公开(公告)号：EP3352587A1

公开(公告)日：2018-08-01

申请号：EP16774847.4

申请日：2016-09-09

Applicant: Christian-Albrechts-Universität zu Kiel

Inventor： WILDE, Sandra Catharina ,  KEPPLER, Julia Katharina ,  SCHWARZ, Karin ,  PALANI, Kalpana ,  TREITZ, Christian ,  KOUDELKA, Thomas ,  THOLEY, Andreas

IPC: A23L33/19 ,  A23L33/105 ,  A23L2/52 ,  A23L2/66 ,  C07C323/65

CPC classification number: A23L33/19 ,  A23L2/52 ,  A23L2/66 ,  A23L27/84 ,  A23L33/105 ,  A61K36/8962

Abstract: The invention relates to a compound having the chemical formula (I), wherein R
1 represents the amino acids 1-120 of beta-lactoglobulin and R
2 the amino acids 122-162 of beta-lactoglobulin from cow's milk. The invention further relates to a method for producing S-allylmercaptocysteine-modified beta-lactoglobulin, comprising the following steps: providing an aqueous solution of beta-lactoglobulin and allicin as a solution C; controlling and adjusting the pH of the solution C to a value of between 7 and 9; and allowing the solution C to react. The invention further relates to a food additive.

公开(公告)号：EP3224242A1

公开(公告)日：2017-10-04

申请号：EP15800901.9

申请日：2015-11-18

Applicant: Neem Biotech Ltd.

Inventor： SAUNDERS, Robert Alun

IPC: C07C319/24 ,  C07C323/65

CPC classification number: C07C319/22 ,  C07C323/65

Abstract: The present invention relates to a process for producing ajoene from allicin via a polymeric substrate, comprising the steps of heating allicin or an allicin solution at a predetermined temperature range such that at least a portion of the allicin is converted to ajoene to form an ajoene solution; and separating the ajoene from the ajoene solution; wherein at least one of the heating or separating steps is conducted via a polymeric substrate. The process for producing ajoene from allicin via a polymeric substrate further comprises a step of retaining the allicin or the allicin solution on the polymeric substrate before the heating step is conducted within or out of the polymeric substrate. The present invention also relates to ajoene or a composition comprising ajoene obtained by the process thereof.

Abstract translation: 本发明涉及一种通过聚合物基质由大蒜素生产阿霍烯的方法，该方法包括以下步骤：在预定温度范围加热大蒜素或大蒜素溶液，使得至少一部分大蒜素转化为阿霍烯以形成阿霍烯溶液 ; 并从阿霍烯溶液中分离阿霍烯; 其中加热或分离步骤中的至少一个经由聚合物基材进行。 通过聚合物基质由大蒜素生产阿霍烯的方法还包括在加热步骤在聚合物基质内部或外部进行之前，将大蒜素或大蒜素溶液保留在聚合物基质上的步骤。 本发明还涉及通过其方法获得的阿霍烯或包含阿霍烯的组合物。

公开(公告)号：EP1740530B8

公开(公告)日：2017-03-01

申请号：EP05736001.8

申请日：2005-03-15

Applicant: Temple University - Of The Commonwealth System of Higher Education ,  Onconova Therapeutics, Inc.

Inventor： REDDY, E., Premkumar ,  REDDY, M., V., Ramana ,  BELL, Stanley, C.

IPC: C07C235/38 ,  C07C271/44 ,  C07C311/27 ,  C07C317/18 ,  C07C317/28 ,  C07C323/41 ,  C07C323/49 ,  C07C323/65 ,  C07D213/02 ,  C07D295/088 ,  C07D295/15 ,  C07D295/155 ,  C07F7/18

CPC classification number: C07C235/38 ,  C07B2200/07 ,  C07C271/44 ,  C07C311/27 ,  C07C317/18 ,  C07C317/28 ,  C07C323/41 ,  C07C323/49 ,  C07C323/65 ,  C07D213/02 ,  C07D295/088 ,  C07D295/15 ,  C07D295/155 ,  C07F7/1852 ,  C07F7/1856

公开(公告)号：EP3020397A3

公开(公告)日：2016-08-17

申请号：EP15197845.9

申请日：2011-12-07

Applicant: Danmarks Tekniske Universitet

Inventor： Givskov, Michael ,  Larsen, Thomas Ostenfeld ,  Bjarnsholt, Thomas ,  Høiby, Niels ,  Jensen, Peter Østrup ,  Phipps, Richard ,  Shanmugham, Meenakshi Sundaram ,  van Gennip, Maria ,  Christensen, Louise Dahl ,  Jakobsen, Tim Holm ,  Tanner, David

IPC: A61K31/105 ,  A61K45/06 ,  A61P31/04 ,  C07C319/22 ,  C07C323/65

CPC classification number: A61K31/105 ,  A61K31/7036 ,  A61K45/06 ,  A61M16/0683 ,  C07C319/22 ,  Y02A50/481 ,  C07C323/65 ,  A61K2300/00

Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal -C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

公开(公告)号：EP1765768B1

公开(公告)日：2013-11-06

申请号：EP05758184.5

申请日：2005-07-06

Applicant: AstraZeneca AB

Inventor： BONNERT, Roger Victor, ,  THOM, Stephen, ,  PATEL, Anil, ,  LUKER, Timothy Jon,

IPC: C07C229/18 ,  C07C255/54 ,  C07C311/08 ,  C07C317/22 ,  C07C317/36 ,  C07C323/52 ,  C07C323/65 ,  C07D213/30 ,  C07D239/26 ,  C07D271/06 ,  A61K31/192 ,  A61P11/00

CPC classification number: C07D213/30 ,  C07C229/18 ,  C07C255/54 ,  C07C311/08 ,  C07C317/22 ,  C07C317/36 ,  C07C323/52 ,  C07C323/65 ,  C07D239/26 ,  C07D271/06

公开(公告)号：EP2649047A1

公开(公告)日：2013-10-16

申请号：EP11799621.5

申请日：2011-12-07

Applicant: Danmarks Tekniske Universitet

Inventor： BJARNSHOLT, Thomas ,  HØIBY, Niels ,  JENSEN, Peter Østrup ,  PHIPPS, Richard ,  SHANMUGHAM, Meenakshi Sundaram ,  GENNIP, Maria van ,  CHRISTENSEN, Louise Dahl ,  JAKOBSEN, Tim Holm ,  TANNER, David ,  LARSEN, Thomas Ostenfeld ,  GIVSKOV, Michael

IPC: C07C319/22 ,  C07C323/65 ,  A61K31/105 ,  A61P31/04

CPC classification number: A61K31/105 ,  A61K31/7036 ,  A61K45/06 ,  A61M16/0683 ,  C07C319/22 ,  Y02A50/481 ,  C07C323/65 ,  A61K2300/00

Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal -C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

公开(公告)号：EP2548860A4

公开(公告)日：2013-09-04

申请号：EP11756144

申请日：2011-03-09

Applicant: SUMITOMO SEIKA CHEMICALS

Inventor： KUAD PAUL ,  KANDA HISAAKI ,  FUJIWARA TAKESHI ,  SHIRAISHI HIROYUKI

IPC: C07C323/65 ,  C07C319/20

CPC classification number: C07C323/65

公开(公告)号：EP2595955A1

公开(公告)日：2013-05-29

申请号：EP11734081.0

申请日：2011-07-19

Applicant: Bayer Intellectual Property GmbH

Inventor： AHRENS, Hartmut ,  FEUCHT, Dieter ,  GATZWEILER, Elmar ,  HÄUSER-HAHN, Isolde ,  ROSINGER, Christopher, Hugh

IPC: C07C317/24 ,  C07C317/44 ,  C07C323/22 ,  C07C323/65 ,  C07D493/08 ,  A01N35/06 ,  A01N41/10 ,  A01N43/16

CPC classification number: C07D493/08 ,  A01N35/06 ,  A01N37/40 ,  A01N41/10 ,  A01N43/12 ,  C07C317/24 ,  C07C317/44 ,  C07C323/22 ,  C07C323/62 ,  C07C323/65 ,  C07C2602/44

Abstract: The invention relates to (4-halogenalkyl-3-thiobenzoyl)cyclohexanediones of general formula (I) and to the use thereof as herbicides. In said formula (I), X, Y, R
1 , R
2 , R
3 and R
4 represent radicals such as hydrogen and organic radicals such as alkyl. A and Z represent oxygen or alkene.

公开(公告)号：EP2595954A1

公开(公告)日：2013-05-29

申请号：EP11733855.8

申请日：2011-07-19

Applicant: Bayer Intellectual Property GmbH

Inventor： AHRENS, Hartmut ,  VAN ALMSICK, Andreas ,  GATZWEILER, Elmar ,  FEUCHT, Dieter ,  HÄUSER-HAHN, Isolde ,  LEHR, Stefan ,  ROSINGER, Christopher, Hugh

IPC: C07C317/24 ,  C07C323/22 ,  C07C323/65 ,  C07D493/08 ,  A01N35/06 ,  A01N41/10 ,  A01N43/16

CPC classification number: C07C317/24 ,  A01N41/10 ,  A01N43/16 ,  C07C323/22 ,  C07C323/65 ,  C07C2602/44 ,  C07D493/08

Abstract: The invention relates to (4-trifluormethyl-3-thiobenzoyl)cyclohexanediones of general formula (I) and use thereof as herbicides. In said formula (I) X, R
1 , R
2 , R
3 and R
4 represent radicals such as hydrogen and organic radicals such as alkyl. A and Z represent oxygen or alklene.