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公开(公告)号：EP0983258A4
公开(公告)日：2001-01-17
申请号：EP98908964
申请日：1998-03-04
申请人： MONSANTO CO
发明人： BARTA THOMAS E , BECKER DANIEL P , VILLAMIL CLARA I , FRESKOS JOHN N , MISCHKE BRENT V , MULLINS PATRICK B , HEINTZ ROBERT M , GETMAN DANIEL P , MCDONALD JOSEPH J
IPC分类号： C07D211/62 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/198 , A61K31/27 , A61K31/341 , A61K31/351 , A61K31/36 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/4025 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4453 , A61K31/4465 , A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K45/00 , A61P1/04 , A61P1/14 , A61P7/02 , A61P7/04 , A61P7/08 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C317/22 , C07C317/44 , C07C317/46 , C07C317/48 , C07C317/50 , C07C323/65 , C07D207/16 , C07D207/404 , C07D211/10 , C07D211/46 , C07D211/52 , C07D211/60 , C07D211/64 , C07D211/96 , C07D213/30 , C07D213/32 , C07D213/34 , C07D213/38 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/71 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/02 , C07D217/26 , C07D233/60 , C07D233/84 , C07D233/90 , C07D235/08 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D241/12 , C07D249/12 , C07D263/32 , C07D263/46 , C07D263/54 , C07D263/56 , C07D263/58 , C07D277/20 , C07D277/26 , C07D277/36 , C07D277/56 , C07D277/62 , C07D277/66 , C07D277/70 , C07D277/74 , C07D277/76 , C07D295/08 , C07D295/14 , C07D295/15 , C07D307/56 , C07D307/68 , C07D309/08 , C07D317/62 , C07D317/64 , C07D333/18 , C07D333/36 , C07D333/38 , C07D333/40 , C07D333/54 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D491/056 , C07D491/113 , C07D493/10 , A61K31/35 , C07D211/54 , C07D407/12
CPC分类号： C07D213/30 , C07C317/22 , C07C317/44 , C07C323/65 , C07D207/16 , C07D211/62 , C07D213/82 , C07D295/15
摘要： An N-hydroxy sulfonyl butanamide compound that inter alia inhibits matrix metalloprotease activity is disclosed as is a treatment process that comprises administering a contemplated N-hydroxy sulfonyl butanamide compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metall protease activity.
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公开(公告)号：EP0939629A4
公开(公告)日：2002-07-17
申请号：EP97936168
申请日：1997-07-22
申请人： MONSANTO CO
发明人： DECRESCENZO GARY , ABBAS ZAHEER S , FRESKOS JOHN N , GETMAN DANIEL P , HEINTZ ROBERT M , MISCHKE BRENT V , MCDONALD JOSEPH J
IPC分类号： C07D295/12 , A61K31/18 , A61K31/195 , A61K31/215 , A61K31/36 , A61K31/40 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/535 , A61P27/00 , C07C311/16 , C07C311/17 , C07C311/29 , C07C323/25 , C07C323/31 , C07C323/32 , C07C323/49 , C07C323/58 , C07C323/60 , C07C323/67 , C07C327/30 , C07D207/48 , C07D211/96 , C07D213/42 , C07D215/36 , C07D231/20 , C07D233/61 , C07D233/64 , C07D233/84 , C07D239/46 , C07D265/30 , C07D277/28 , C07D295/13 , C07D307/54 , C07D317/62 , C07D333/20 , C07D333/24 , C07D333/34 , C07D333/36 , C07D333/38 , C07D333/40 , C07D333/62 , C07D401/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , A61K31/21 , A61K31/22 , A61K31/38 , A61K31/415 , A61K31/44
CPC分类号： C07D295/13 , C07C311/17 , C07C311/29 , C07C323/49 , C07D207/48 , C07D211/96 , C07D213/42 , C07D317/62 , C07D409/04
摘要： This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfonamide inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with phatological matrix metalloproteinase activity related to MMP-13.
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公开(公告)号：EP0983267A4
公开(公告)日：2001-04-11
申请号：EP98911480
申请日：1998-03-04
申请人： MONSANTO CO
发明人： HEINTZ ROBERT M , GETMAN DANIEL P , MCDONALD JOSEPH J , DECRESCENZO GARY A , HOWARD SUSAN C , ABBAS S ZAHEER
IPC分类号： C07D249/12 , A61K31/18 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/423 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4453 , A61K31/4465 , A61K31/4545 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/04 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/02 , A61P9/10 , A61P13/12 , A61P17/02 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C311/46 , C07C323/67 , C07D207/08 , C07D209/18 , C07D209/48 , C07D211/14 , C07D211/22 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/81 , C07D213/82 , C07D215/36 , C07D233/42 , C07D233/64 , C07D235/28 , C07D239/38 , C07D239/93 , C07D241/12 , C07D257/04 , C07D263/46 , C07D263/58 , C07D265/30 , C07D271/10 , C07D277/20 , C07D277/24 , C07D277/26 , C07D277/36 , C07D277/56 , C07D277/78 , C07D285/08 , C07D285/125 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/18 , C07D307/38 , C07D307/64 , C07D307/68 , C07D307/79 , C07D309/12 , C07D317/56 , C07D317/62 , C07D333/18 , C07D333/34 , C07D333/38 , C07D333/54 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D513/04 , H04N7/088
CPC分类号： C07C311/46 , C07D213/42 , C07D213/82 , C07D295/13 , C07D309/12 , C07D417/12
摘要： An amidoaromatic ring sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as are a treatment process that comprises administering a contemplated amidoaromatic ring sulfonamide hydroxamic acid compound in an MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
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公开(公告)号：EP0984959A4
公开(公告)日：2001-05-02
申请号：EP98910177
申请日：1998-03-04
申请人： MONSANTO CO
发明人： FRESKOS JOHN N , BOEHM TERRI L , MISCHKE BRENT V , HEINTZ ROBERT M , MCDONALD JOSEPH J , DECRESCENZO GARY A , HOWARD SUSAN C
IPC分类号： C07D211/62 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/198 , A61K31/27 , A61K31/341 , A61K31/351 , A61K31/36 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/4025 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4453 , A61K31/4465 , A61K31/451 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K45/00 , A61P1/04 , A61P1/14 , A61P7/02 , A61P7/04 , A61P7/08 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/02 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C317/22 , C07C317/44 , C07C317/46 , C07C317/48 , C07C317/50 , C07C323/65 , C07D207/16 , C07D207/404 , C07D211/10 , C07D211/46 , C07D211/52 , C07D211/60 , C07D211/64 , C07D211/96 , C07D213/30 , C07D213/32 , C07D213/34 , C07D213/38 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/71 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/02 , C07D217/26 , C07D233/60 , C07D233/84 , C07D233/90 , C07D235/08 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D241/12 , C07D249/12 , C07D263/32 , C07D263/46 , C07D263/54 , C07D263/56 , C07D263/58 , C07D277/20 , C07D277/26 , C07D277/36 , C07D277/56 , C07D277/62 , C07D277/66 , C07D277/70 , C07D277/74 , C07D277/76 , C07D295/08 , C07D295/14 , C07D295/15 , C07D307/56 , C07D307/68 , C07D309/08 , C07D317/62 , C07D317/64 , C07D333/18 , C07D333/36 , C07D333/38 , C07D333/40 , C07D333/54 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D491/056 , C07D491/113 , C07D493/10 , A61K31/455 , A61K31/535
CPC分类号： C07D213/30 , C07C317/22 , C07C317/44 , C07C323/65 , C07D207/16 , C07D211/62 , C07D213/82 , C07D295/15
摘要： An aromatic sulfonyl alpha-hydroxy hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
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公开(公告)号：EP0977745A4
公开(公告)日：2000-05-31
申请号：EP98911479
申请日：1998-03-04
申请人： MONSANTO CO
发明人： GETMAN DANIEL P , BECKER DANIEL P , BARTA THOMAS E , VILLAMIL CLARA I , HOCKERMAN SUSAN L , BEDELL LOUIS J , LI MADELEINE H , FRESKOS JOHN N , HEINTZ ROBERT M , MCDONALD JOSEPH J , DECRESCENZO GARY A
IPC分类号： C07D249/12 , A61K31/18 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/423 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4453 , A61K31/4465 , A61K31/4545 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/04 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/02 , A61P9/10 , A61P13/12 , A61P17/02 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07C311/46 , C07C323/67 , C07D207/08 , C07D209/18 , C07D209/48 , C07D211/14 , C07D211/22 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/81 , C07D213/82 , C07D215/36 , C07D233/42 , C07D233/64 , C07D235/28 , C07D239/38 , C07D239/93 , C07D241/12 , C07D257/04 , C07D263/46 , C07D263/58 , C07D265/30 , C07D271/10 , C07D277/20 , C07D277/24 , C07D277/26 , C07D277/36 , C07D277/56 , C07D277/78 , C07D285/08 , C07D285/125 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/18 , C07D307/38 , C07D307/64 , C07D307/68 , C07D307/79 , C07D309/12 , C07D317/56 , C07D317/62 , C07D333/18 , C07D333/34 , C07D333/38 , C07D333/54 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D513/04 , H04N7/088
CPC分类号： C07C311/46 , C07D213/42 , C07D213/82 , C07D295/13 , C07D309/12 , C07D417/12
摘要： A thioaryl sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated thioaryl sulfonamide hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
摘要翻译： 公开了尤其抑制基质金属蛋白酶活性的硫代芳基磺酰胺异羟肟酸化合物，该方法包括给予具有与病理基质金属蛋白酶活性有关的病症的基质的MMP抑制有效量的预期硫代芳基磺酰胺异羟肟酸化合物 。
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公开(公告)号：EP0939628A4
公开(公告)日：1999-12-22
申请号：EP97936169
申请日：1997-07-22
申请人： MONSANTO CO
发明人： FRESKOS JOHN N , ABBAS ZAHEER S , DECRESCENZO GARY A , GETMAN DANIEL P , HEINTZ ROBERT M , MISCHKE BRENT V , MCDONALD JOSEPH J
IPC分类号： C07D295/08 , A61K31/10 , A61K31/165 , A61K31/17 , A61K31/192 , A61K31/216 , A61K31/22 , A61K31/27 , A61K31/4164 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/5375 , A61K31/5377 , A61P43/00 , C07C317/22 , C07C317/32 , C07C323/65 , C07C327/22 , C07C327/24 , C07C327/26 , C07C327/28 , C07C327/32 , C07D213/34 , C07D213/70 , C07D233/84 , C07D277/20 , C07D277/36 , C07D295/12 , A61K31/19 , A61K31/215 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/535 , C07C237/20
CPC分类号： A61K31/10 , A61K31/17 , A61K31/4164 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/5377 , C07C317/22 , C07C323/65 , C07C327/24 , C07C327/26 , C07C2601/08 , C07C2601/14
摘要： This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.
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