发明公开
EP1171594A1 VASCULAR ENDOTHELIAL CELL GROWTH FACTOR VARIANTS AND USES THEREOF
有权
血管内皮生长因子(VEGF)选项及其用途
- 专利标题: VASCULAR ENDOTHELIAL CELL GROWTH FACTOR VARIANTS AND USES THEREOF
- 专利标题(中): 血管内皮生长因子(VEGF)选项及其用途
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申请号: EP00921966.8申请日: 2000-04-10
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公开(公告)号: EP1171594A1公开(公告)日: 2002-01-16
- 发明人: CUNNINGHAM, Brian , DEVOS, Abraham , LI, Bing
- 申请人: Genentech, Inc.
- 申请人地址: 1 DNA Way South San Francisco, CA 94080-4990 US
- 专利权人: Genentech, Inc.
- 当前专利权人: Genentech, Inc.
- 当前专利权人地址: 1 DNA Way South San Francisco, CA 94080-4990 US
- 代理机构: Denison, Christopher Marcus
- 优先权: US129788P 19990416; US184235P 20000223
- 国际公布: WO0063380 20001026
- 主分类号: C12N15/12
- IPC分类号: C12N15/12 ; C12N5/10 ; C07K14/52 ; G01N33/566 ; A61K38/18
摘要:
The present invention provides VEGF variants having at least a single amino acid mutation in the native VEGF sequence and selective binding affinity for either the KDR receptor or the FLT-1 receptor. Methods of making the VEGF variants and methods of using the VEGF variants are also provided.
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