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公开(公告)号：EP2280996A2
公开(公告)日：2011-02-09
申请号：EP09743591.1
申请日：2009-05-06
申请人： Genentech, Inc.
IPC分类号： C07K14/705 , G01N33/68 , A61K38/17 , A61P37/00
CPC分类号： A61K38/1774 , A61K38/00 , C07K14/70503 , Y02A50/463
摘要： The present invention concerns affinity matured CRIg variants. In particular, the invention concerns CRIg variants having increased binding affinity to C3b and retaining selective binding to C3b over C3.
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2.发明授权VARIANTS OF VASCULAR ENDOTHELIAL CELL GROWTH FACTOR, THEIR USES, AND PROCESSES FOR THEIR PORDUCTION 失效血管内皮细胞，使用生长因子及其制备变异与方法
公开(公告)号：EP0851920B1
公开(公告)日：2008-06-25
申请号：EP96929012.1
申请日：1996-08-23
申请人： GENENTECH, INC.
发明人： KEYT, Bruce , NGUYEN, Francis, Hung , FERRARA, Napoleone , CUNNINGHAM, Brian, C. , WELLS, James, A. , LI, Bing
CPC分类号： C07K14/515 , A61K38/00 , C07K14/52 , G01N33/74 , G01N2500/00
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公开(公告)号：EP1756164A2
公开(公告)日：2007-02-28
申请号：EP05769494.5
申请日：2005-04-04
申请人： GENENTECH, INC.
发明人： LI, Bing , SIDHU, Sachdev, S.
IPC分类号： C07K16/28 , A61P37/00 , A61K39/395 , C07K16/32 , A61P35/00
CPC分类号： C07K16/2878 , C07K2317/24 , C07K2317/55 , C07K2317/622
摘要： The application provides antibodies which specifically bind to DR5 receptor. The anti-DR5 antibodies optionally contain CDR sequences identified using phage-display techniques. The DR5 antibodies can be used, for example, in methods where a modulation of the biological activities of Apo-2L and/or Apo-2L receptors is desired, including cancer and immune-related conditions.
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公开(公告)号：EP1622929B1
公开(公告)日：2006-10-11
申请号：EP04760861.7
申请日：2004-04-29
申请人： GENENTECH, INC.
发明人： LI, Bing , SIDHU, Sachdev, S.
IPC分类号： C07K7/04 , A61K38/04 , C07K14/705 , C12N15/10
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4747 , C07K14/525 , C07K14/70575
摘要： Peptides are provided that bind Apo-2L receptor molecules. These peptides can be used for example in methods where a modulation of the biological activities of Apo-2L and/or Apo-2L receptor molecules such as DR5 is desired.
摘要翻译： 提供结合Apo-2L受体分子的肽。 这些肽可用于例如需要调节Apo-2L和/或Apo-2L受体分子如DR5的生物活性的方法中。
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公开(公告)号：EP3141560A3
公开(公告)日：2017-05-24
申请号：EP16173577.4
申请日：2009-05-06
申请人： Genentech, Inc.
IPC分类号： C07K14/705 , G01N33/68 , A61P37/00 , A61K38/17
CPC分类号： A61K38/1774 , A61K38/00 , C07K14/70503 , Y02A50/463
摘要： The present invention concerns affinity matured CRIg variants. In particular, the invention concerns CRIg variants having increased binding affinity to C3b and retaining selective binding to C3b over C3.
摘要翻译： 本发明涉及亲和力成熟的CRIg变体。 具体而言，本发明涉及对C3b具有增加的结合亲和力并保持与C3b对C3b的选择性结合的CRIg变体。
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6.发明公开VARIANTS OF VASCULAR ENDOTHELIAL CELL GROWTH FACTOR, THEIR USES, AND PROCESSES FOR THEIR PORDUCTION 失效血管内皮细胞，使用生长因子及其制备变异与方法
公开(公告)号：EP0851920A1
公开(公告)日：1998-07-08
申请号：EP96929012.0
申请日：1996-08-23
申请人： GENENTECH, INC.
发明人： KEYT, Bruce , NGUYEN, Francis, Hung , FERRARA, Napoleone , CUNNINGHAM, Brian, C. , WELLS, James, A. , LI, Bing
CPC分类号： C07K14/515 , A61K38/00 , C07K14/52 , G01N33/74 , G01N2500/00
摘要： The present invention involves the preparation of vascular endothelial growth factor (VEGF) variants which provide materials that are selective in respect of binding characteristics to the kinase domain region and the FMS-like tyrosine-kinase region, respectively KDR and FLT-1. The respective KDR and FLT-1 receptors are bound by corresponding domains within the VEGF compound domains. The variants hereof define those two binding regions and modify them so as to introduce changes that interrupt the binding to the respective domain. In this fashion the final biological characteristics of the VEGF molecule are selectively modified.
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公开(公告)号：EP2280996B1
公开(公告)日：2016-09-07
申请号：EP09743591.1
申请日：2009-05-06
申请人： Genentech, Inc.
IPC分类号： C07K14/705 , G01N33/68 , A61K38/17 , A61P37/00
CPC分类号： A61K38/1774 , A61K38/00 , C07K14/70503 , Y02A50/463
摘要： The present invention concerns affinity matured CRIg variants. In particular, the invention concerns CRIg variants having increased binding affinity to C3b and retaining selective binding to C3b over C3.
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公开(公告)号：EP3141560A2
公开(公告)日：2017-03-15
申请号：EP16173577.4
申请日：2009-05-06
申请人： Genentech, Inc.
IPC分类号： C07K14/705 , G01N33/68 , A61P37/00 , A61K38/17
CPC分类号： A61K38/1774 , A61K38/00 , C07K14/70503 , Y02A50/463
摘要： The present invention concerns affinity matured CRIg variants. In particular, the invention concerns CRIg variants having increased binding affinity to C3b and retaining selective binding to C3b over C3.
摘要翻译： 本发明涉及亲和力成熟的CRIg变体。 特别地，本发明涉及具有增加的对C3b的结合亲和力并保留在C3上选择性结合C3b的CRIg变体。
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公开(公告)号：EP1171594B1
公开(公告)日：2006-06-07
申请号：EP00921966.8
申请日：2000-04-10
申请人： GENENTECH, INC.
发明人： CUNNINGHAM, Brian , DEVOS, Abraham , LI, Bing
IPC分类号： C12N15/12 , C12N5/10 , C07K14/52 , G01N33/566 , A61K38/18
摘要： The present invention provides VEGF variants having at least a single amino acid mutation in the native VEGF sequence and selective binding affinity for either the KDR receptor or the FLT-1 receptor. Methods of making the VEGF variants and methods of using the VEGF variants are also provided.
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10.发明公开APO2L (TRAIL) RECEPTOR BINDING PEPTIDES AND USES THEREOF 有权肽什么对Apo2L（TRAIL）受体的结合和VERWENDUNGNEN THEREOF
公开(公告)号：EP1622929A2
公开(公告)日：2006-02-08
申请号：EP04760861.7
申请日：2004-04-29
申请人： GENENTECH, INC.
发明人： LI, Bing , SIDHU, Sachdev, S.
IPC分类号： C07K7/04 , A61K38/04 , C07K14/705 , C12N15/10
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4747 , C07K14/525 , C07K14/70575
摘要： Peptides are provided that bind Apo-2L receptor molecules. These peptides can be used for example in methods where a modulation of the biological activities of Apo-2L and/or Apo-2L receptor molecules such as DR5 is desired.
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