专利检索 ap:("Genentech, Inc.") AND inv:"CUNNINGHAM, Brian" 第 1 页

1.

发明授权
VASCULAR ENDOTHELIAL CELL GROWTH FACTOR VARIANTS AND USES THEREOF 有权
标题翻译：血管内皮生长因子（VEGF）选项及其用途

公开(公告)号：EP1171594B1

公开(公告)日：2006-06-07

申请号：EP00921966.8

申请日：2000-04-10

申请人： GENENTECH, INC.

发明人： CUNNINGHAM, Brian , DEVOS, Abraham , LI, Bing

IPC分类号： C12N15/12 , C12N5/10 , C07K14/52 , G01N33/566 , A61K38/18

CPC分类号： C07K14/52 , A61K9/009 , A61K9/06 , A61K38/00

摘要： The present invention provides VEGF variants having at least a single amino acid mutation in the native VEGF sequence and selective binding affinity for either the KDR receptor or the FLT-1 receptor. Methods of making the VEGF variants and methods of using the VEGF variants are also provided.

2.

发明公开
VASCULAR ENDOTHELIAL CELL GROWTH FACTOR VARIANTS AND USES THEREOF 有权
标题翻译：血管内皮生长因子（VEGF）选项及其用途

公开(公告)号：EP1171594A1

公开(公告)日：2002-01-16

申请号：EP00921966.8

申请日：2000-04-10

申请人： Genentech, Inc.

发明人： CUNNINGHAM, Brian , DEVOS, Abraham , LI, Bing

IPC分类号： C12N15/12 , C12N5/10 , C07K14/52 , G01N33/566 , A61K38/18

CPC分类号： C07K14/52 , A61K9/009 , A61K9/06 , A61K38/00

摘要： The present invention provides VEGF variants having at least a single amino acid mutation in the native VEGF sequence and selective binding affinity for either the KDR receptor or the FLT-1 receptor. Methods of making the VEGF variants and methods of using the VEGF variants are also provided.