发明公开
- 专利标题： Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
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申请号： EP04002427.5申请日： 2002-09-25
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公开(公告)号： EP1419776A3公开(公告)日： 2004-06-16
- 发明人: Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimara, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji ,
- 申请人： OTSUKA PHARMACEUTICAL CO., LTD.
- 申请人地址： 9, Kandatsukasa-cho 2-chome Chiyoda-ku Tokyo 101-8535 JP
- 专利权人： OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人： OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 9, Kandatsukasa-cho 2-chome Chiyoda-ku Tokyo 101-8535 JP
- 代理机构： HOFFMANN - EITLE
- 优先权： JP2001290645 20010925; JP2001348276 20011114; CA2379005 20020327
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D215/22 ; A61P25/18
摘要：
The present invention provides low-hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
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