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23 条记录 (耗时 0.016 秒)

    Process for preparing benzazepine compounds or salts thereof
    1.
    发明公开
    Process for preparing benzazepine compounds or salts thereof 有权
    Verfahrenfürdie Zubereitung von Benzazepineverbindungen oder Salzen daraus

    公开(公告)号：EP2261215A1

    公开(公告)日：2010-12-15

    申请号：EP10174000.9

    申请日：2006-09-01

    申请人： Otsuka Pharmaceutical Co., Ltd.

    发明人： Torisawa, Yasuhiro ,  Abe, Kaoru ,  Muguruma, Yasuaki ,  Fujita, Shigekazu ,  Ogawa, Hidenori ,  Utsumi, Naoto ,  Miyake, Masahiro

    IPC分类号： C07D223/16

    CPC分类号： C07D223/16 ,  C07C231/12 ,  C07C233/81

    摘要： This invention provides a process for preparing benzazepine compounds of the formula (1):

    wherein X 1 is a halogen atom, R 1 and R 2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.

    摘要翻译： 本发明提供了制备式（1）的苯并氮杂化合物的方法：其中X 1为卤素原子，R 1和R 2为低级烷基，或其盐以及高产率和高的中间体苯甲酸化合物 其可用作制备具有加压素拮抗活性的药学活性2,3,4,5-四氢-1H-1-苯并氮杂化合物的中间体。

    Method for preparing 1-substituted-4-nitroimidazole compound
    9.
    发明公开
    Method for preparing 1-substituted-4-nitroimidazole compound 有权
    Verfahren zur Herstellung einer 2-Halo-4-Nitroimidazolverbindung

    公开(公告)号：EP2644599A1

    公开(公告)日：2013-10-02

    申请号：EP13174291.8

    申请日：2003-10-14

    申请人： OTSUKA PHARMACEUTICAL CO., LTD.

    发明人： Goto, Fumitaka ,  Takemura, Noriaki ,  Otani, Tadaaki ,  Hasegawa, Takeshi ,  Tsubouchi, Hidetsugu ,  Utsumi, Naoto ,  Fujita, Shigekazu ,  Kuroda, Hideaki ,  Shitsuta, Takuya ,  Sasaki, Hirofumi

    IPC分类号： C07D233/92

    CPC分类号： C07D233/92

    摘要： The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof,

    (wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a phenyl-lower alkoxy group-substituted lower alkyl group, a cyano-substituted lower alkyl group, a phenyl-lower alkyl group which may have lower alkoxy groups as the substituents in the phenyl ring or a group of the formula -CH 2 R A ; X is a halogen atom or a group of the formula -S(O)n-R 1 ) and method for preparing the same. The compound of the formula (1) is a useful compound as an intermediate for synthesis of various pharmaceutical and agricultural chemicals, particularly, as intermediates for antitubercular agents.

    摘要翻译： 本发明涉及由通式（1）表示的1-取代-4-硝基咪唑化合物或其盐（其中R为氢原子，低级烷氧基取代的低级烷基，苯基 - 低级烷氧基 取代基低级烷基，氰基取代的低级烷基，可具有低级烷氧基作为苯环中的取代基的苯基 - 低级烷基或式-CH 2 RA基团; X是卤素原子 或式-S（O）n R 1的基团）及其制备方法。 式（1）的化合物是用作合成各种药用和农药的中间体的有用化合物，特别是作为抗结核剂的中间体。

    Process for preparing derivatives of benzoic acid
    10.
    发明公开
    Process for preparing derivatives of benzoic acid 有权
    Verfahren zur Herstellung von Benzoesaure Derivaten

    公开(公告)号：EP2251319A3

    公开(公告)日：2011-03-09

    申请号：EP10174006.6

    申请日：2006-09-01

    申请人： Otsuka Pharmaceutical Co., Ltd.

    发明人： Torisawa, Yasuhiro ,  Abe, Kaoru ,  Muguruma, Yasuaki ,  Fujita, Shigekazu ,  Ogawa, Hidenori ,  Utsumi, Naoto ,  Miyake, Masahiro

    IPC分类号： C07C233/81

    CPC分类号： C07D223/16 ,  C07C231/12 ,  C07C233/81

    摘要： This invention provides a process for preparing benzazepine compounds of the formula (1):

    wherein X 1 is a halogen atom, R 1 and R 2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.

    摘要翻译： 本发明提供了制备式（1）的苯并氮杂化合物的方法：其中X 1为卤素原子，R 1和R 2为低级烷基，或其盐以及高产率和高的中间体苯甲酸化合物 其可用作制备具有加压素拮抗活性的药学活性2,3,4,5-四氢-1H-1-苯并氮杂化合物的中间体。