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1.发明授权
公开(公告)号：EP1927357B1
公开(公告)日：2010-05-12
申请号：EP08000360.1
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
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2.发明公开Low hygroscopic aripiprazole (crystal F) drug substance and processes for the preparation thereof 有权Gering hygroskopische Aripiprazol-Substanz（Kristal F）und Herstellungsverfahren
公开(公告)号：EP1927355A1
公开(公告)日：2008-06-04
申请号：EP08000357.7
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides an improved low hygroscopic form, form F, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
摘要翻译： 本发明提供了阿立哌唑的改进的低吸湿形式，形式F，其制备方法即使在含有阿立哌唑酐晶体的药物制剂长时间储存时也不会转化为水合物或失去其原始溶解度。
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3.发明授权
公开(公告)号：EP1419776B2
公开(公告)日：2017-07-19
申请号：EP04002427.5
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
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4.发明公开PHARMACEUTICAL SOLID ORAL ARIPIPRAZOLE PREPARATION AND PROCESSES FOR THE PREPARATION THEREOF 审中-公开固体口服药物组合物及其制备方法阿立哌唑
公开(公告)号：EP3081216A1
公开(公告)日：2016-10-19
申请号：EP16169141.5
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： A pharmaceutical solid oral aripiprazole preparation is provided which has
a) at least one dissolution rate measured after storage in the open at 25°C/60% RH for six months selected from the group consisting of 70 % or more at pH 4.5 after 60 minutes, and 55 % or more at pH 5.0 after 60 minutes; or
b) at least one dissolution rate measured after storage in the open at 40°C/75% RH for 1 week selected from the group consisting of 70 % or more at pH 4.5 after 60 minutes, and 55 % or more at pH 5.0 after 60 minutes.摘要翻译： 本发明提供一种药用固体口服阿立哌唑制剂，其具有储存后测得的开放在25℃/ 60％RH：a）至少一种溶出速率为在pH 4.5从该组由70％或更多选定6个月60分钟后 和55％或60分钟后更在pH 5.0; 或b）至少一种在pH 5.0储存后测得的开放在40℃/ 75％RH下60分钟后从该组由70％或更多在pH4.5中的1周，和55％或更多的溶解速率 60分钟后。
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5.发明授权Pharmaceutical solid oral aripiprazole preparation and processes for the preparation thereof 无效Feste orale pharmazeutische Zusammensetzung von Aripiprazol und Verfahrenfürderen Herstellung
公开(公告)号：EP1925308B1
公开(公告)日：2016-08-31
申请号：EP08000358.5
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
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6.发明授权
公开(公告)号：EP1927356B1
公开(公告)日：2010-04-28
申请号：EP08000359.3
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
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7.发明公开Low hygroscopic aripiprazole drug substance and processes for the preparation thereof 有权阿立哌唑Wirkstoff mit niedriger Hygroskopie und Verfahren zu ihrer Herstellung
公开(公告)号：EP1419776A2
公开(公告)日：2004-05-19
申请号：EP04002427.5
申请日：2002-09-25
发明人： Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimara, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji ,
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides low-hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
摘要翻译： 本发明提供低吸湿形式的阿立哌唑及其制备方法，即使当含有阿立哌唑酐晶体的药物制剂长时间储存时，其也不会转化为水合物或丧失其原始溶解度。
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8.发明公开Low hygroscopic aripiprazole (crystal E) drug substance and processes for the preparation thereof 有权低吸湿性阿立哌唑（晶体E）原料药及其制备方法
公开(公告)号：EP1927357A2
公开(公告)日：2008-06-04
申请号：EP08000360.1
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides an improved low hygroscopic form, form E, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
摘要翻译： 本发明提供了一种改进的低吸湿性形式E型阿立哌唑及其制备方法，即使当含有阿立哌唑无水物晶体的药物制剂长时间储存时，其也不会转化成水合物或失去它们的初始溶解度。
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9.发明公开Low hygroscopic aripiprazole (crystal G) drug substance and processes for the preparation thereof 无效Feste orale pharmazeutische Zusammensetzung von Aripiprazol und Verfahrenfürderen Herstellung
公开(公告)号：EP1925308A1
公开(公告)日：2008-05-28
申请号：EP08000358.5
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides an improved low hygroscopic form, form G, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
摘要翻译： 本发明提供了一种改进的低吸湿形式，阿立哌唑的形式G及其制备方法，即使当含有阿立哌唑酐晶体的药物制剂长时间储存时，其也不会转化为水合物或失去其原始溶解度。
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公开(公告)号：EP1419776A3
公开(公告)日：2004-06-16
申请号：EP04002427.5
申请日：2002-09-25
发明人： Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimara, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji ,
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides low-hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
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