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1.发明授权
公开(公告)号：EP1927355B1
公开(公告)日：2010-04-28
申请号：EP08000357.7
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
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2.发明公开Low hygroscopic aripiprazole (crystal E) drug substance and processes for the preparation thereof 有权低吸湿性阿立哌唑（晶体E）原料药及其制备方法
公开(公告)号：EP1927357A2
公开(公告)日：2008-06-04
申请号：EP08000360.1
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides an improved low hygroscopic form, form E, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
摘要翻译： 本发明提供了一种改进的低吸湿性形式E型阿立哌唑及其制备方法，即使当含有阿立哌唑无水物晶体的药物制剂长时间储存时，其也不会转化成水合物或失去它们的初始溶解度。
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3.发明公开Low hygroscopic aripiprazole (crystal G) drug substance and processes for the preparation thereof 无效Feste orale pharmazeutische Zusammensetzung von Aripiprazol und Verfahrenfürderen Herstellung
公开(公告)号：EP1925308A1
公开(公告)日：2008-05-28
申请号：EP08000358.5
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides an improved low hygroscopic form, form G, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
摘要翻译： 本发明提供了一种改进的低吸湿形式，阿立哌唑的形式G及其制备方法，即使当含有阿立哌唑酐晶体的药物制剂长时间储存时，其也不会转化为水合物或失去其原始溶解度。
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公开(公告)号：EP1419776A3
公开(公告)日：2004-06-16
申请号：EP04002427.5
申请日：2002-09-25
发明人： Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimara, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji ,
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides low-hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
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5.发明授权Low hygroscopic aripiprazole drug substance and processes for the preparation thereof 有权阿立哌唑药物具有吸湿性低，它们的制备方法
公开(公告)号：EP1419776B1
公开(公告)日：2010-04-14
申请号：EP04002427.5
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
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6.发明公开
公开(公告)号：EP1927357A3
公开(公告)日：2008-06-11
申请号：EP08000360.1
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides an improved low hygroscopic form, form E, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
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7.发明公开Low hygroscopic aripiprazole (crystal D) drug substance and processes for the preparation thereof 有权Gering hygroskopische Aripiprazol-Substanz（Kristal D）und Herstellungsverfahren
公开(公告)号：EP1927356A1
公开(公告)日：2008-06-04
申请号：EP08000359.3
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides an improved low hygroscopic form, form D, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
摘要翻译： 本发明提供了改进的阿立哌唑的低吸湿形式，形式D和其制备方法，即使当含有阿立哌唑酐晶体的药物制剂长时间储存时，其也不会转化为水合物或丧失其原始溶解度。
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8.发明公开
公开(公告)号：EP1419776A9
公开(公告)日：2004-09-08
申请号：EP04002427.5
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimara, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides low-hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
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9.发明公开Low hygroscopic aripiprazole drug substance and processes for the preparation thereof 有权阿立哌唑药物具有吸湿性低，它们的制备方法
公开(公告)号：EP1419776A8
公开(公告)日：2004-09-01
申请号：EP04002427.5
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimara, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides low-hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
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10.发明授权
公开(公告)号：EP1927357B1
公开(公告)日：2010-05-12
申请号：EP08000360.1
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
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