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1.发明公开Process for preparing benzazepine compounds or salts thereof 有权Verfahrenfürdie Zubereitung von Benzazepineverbindungen oder Salzen daraus
公开(公告)号：EP2261215A1
公开(公告)日：2010-12-15
申请号：EP10174000.9
申请日：2006-09-01
发明人： Torisawa, Yasuhiro , Abe, Kaoru , Muguruma, Yasuaki , Fujita, Shigekazu , Ogawa, Hidenori , Utsumi, Naoto , Miyake, Masahiro
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07C231/12 , C07C233/81
摘要： This invention provides a process for preparing benzazepine compounds of the formula (1):
wherein X 1 is a halogen atom, R 1 and R 2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.摘要翻译： 本发明提供了制备式（1）的苯并氮杂化合物的方法：其中X 1为卤素原子，R 1和R 2为低级烷基，或其盐以及高产率和高的中间体苯甲酸化合物 其可用作制备具有加压素拮抗活性的药学活性2,3,4,5-四氢-1H-1-苯并氮杂化合物的中间体。
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公开(公告)号：EP2251319A2
公开(公告)日：2010-11-17
申请号：EP10174006.6
申请日：2006-09-01
发明人： Torisawa, Yasuhiro , Abe, Kaoru , Muguruma, Yasuaki , Fujita, Shigekazu , Ogawa, Hidenori , Utsumi, Naoto , Miyake, Masahiro
IPC分类号： C07C233/81
CPC分类号： C07D223/16 , C07C231/12 , C07C233/81
摘要： This invention provides a process for preparing benzazepine compounds of the formula (1):
wherein X 1 is a halogen atom, R 1 and R 2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.-
3.发明授权
公开(公告)号：EP1927355B1
公开(公告)日：2010-04-28
申请号：EP08000357.7
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
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4.发明授权
公开(公告)号：EP2261215B1
公开(公告)日：2014-12-31
申请号：EP10174000.9
申请日：2006-09-01
发明人： Torisawa, Yasuhiro , Abe, Kaoru , Muguruma, Yasuaki , Fujita, Shigekazu , Ogawa, Hidenori , Utsumi, Naoto , Miyake, Masahiro
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07C231/12 , C07C233/81
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5.发明公开Process for preparing derivatives of benzoic acid 有权Verfahren zur Herstellung von Benzoesaure Derivaten
公开(公告)号：EP2251319A3
公开(公告)日：2011-03-09
申请号：EP10174006.6
申请日：2006-09-01
发明人： Torisawa, Yasuhiro , Abe, Kaoru , Muguruma, Yasuaki , Fujita, Shigekazu , Ogawa, Hidenori , Utsumi, Naoto , Miyake, Masahiro
IPC分类号： C07C233/81
CPC分类号： C07D223/16 , C07C231/12 , C07C233/81
摘要： This invention provides a process for preparing benzazepine compounds of the formula (1):
wherein X 1 is a halogen atom, R 1 and R 2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.摘要翻译： 本发明提供了制备式（1）的苯并氮杂化合物的方法：其中X 1为卤素原子，R 1和R 2为低级烷基，或其盐以及高产率和高的中间体苯甲酸化合物 其可用作制备具有加压素拮抗活性的药学活性2,3,4,5-四氢-1H-1-苯并氮杂化合物的中间体。
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6.发明授权
公开(公告)号：EP1927357B1
公开(公告)日：2010-05-12
申请号：EP08000360.1
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
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7.发明公开Low hygroscopic aripiprazole (crystal F) drug substance and processes for the preparation thereof 有权Gering hygroskopische Aripiprazol-Substanz（Kristal F）und Herstellungsverfahren
公开(公告)号：EP1927355A1
公开(公告)日：2008-06-04
申请号：EP08000357.7
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides an improved low hygroscopic form, form F, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
摘要翻译： 本发明提供了阿立哌唑的改进的低吸湿形式，形式F，其制备方法即使在含有阿立哌唑酐晶体的药物制剂长时间储存时也不会转化为水合物或失去其原始溶解度。
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8.发明公开Low hygroscopic aripiprazole (crystal E) drug substance and processes for the preparation thereof 有权低吸湿性阿立哌唑（晶体E）原料药及其制备方法
公开(公告)号：EP1927357A2
公开(公告)日：2008-06-04
申请号：EP08000360.1
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides an improved low hygroscopic form, form E, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
摘要翻译： 本发明提供了一种改进的低吸湿性形式E型阿立哌唑及其制备方法，即使当含有阿立哌唑无水物晶体的药物制剂长时间储存时，其也不会转化成水合物或失去它们的初始溶解度。
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9.发明公开Low hygroscopic aripiprazole (crystal G) drug substance and processes for the preparation thereof 无效Feste orale pharmazeutische Zusammensetzung von Aripiprazol und Verfahrenfürderen Herstellung
公开(公告)号：EP1925308A1
公开(公告)日：2008-05-28
申请号：EP08000358.5
申请日：2002-09-25
发明人： Bando, Takuji , Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimura, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides an improved low hygroscopic form, form G, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
摘要翻译： 本发明提供了一种改进的低吸湿形式，阿立哌唑的形式G及其制备方法，即使当含有阿立哌唑酐晶体的药物制剂长时间储存时，其也不会转化为水合物或失去其原始溶解度。
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公开(公告)号：EP1419776A3
公开(公告)日：2004-06-16
申请号：EP04002427.5
申请日：2002-09-25
发明人： Aoki, Satoshi , Kawasaki, Junichi , Ishigami, Makoto , Taniguchi, Youichi , Yabuuchi, Tsuyoshi , Fujimoto, Kiyoshi , Nishioka, Yoshihiro , Kobayashi, Noriyuki , Fujimara, Tsutomu , Takahashi, Masanori , Abe, Kaoru , Nakagawa, Tomonori , Shinhama, Koichi , Utsumi, Naoto , Tominaga, Michiaki , Oi, Yoshihiro , Yamada, Shohei , Tomikawa, Kenji ,
IPC分类号： A61K31/496 , C07D215/22 , A61P25/18
CPC分类号： C07D215/227 , C07B2200/13 , C07D215/22 , Y10T428/2982
摘要： The present invention provides low-hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
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