发明公开
EP1549598A4 NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)
审中-公开
萘衍生物; 细胞因子或生物AKTIVITûT迁移抑制因子的巨噬细胞抑制（MIF）
- 专利标题： NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)
- 专利标题（中）： 萘衍生物; 细胞因子或生物AKTIVITûT迁移抑制因子的巨噬细胞抑制（MIF）
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申请号： EP03724672申请日： 2003-06-06
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公开(公告)号： EP1549598A4公开(公告)日： 2008-01-23
- 发明人: MORAND ERIC FRANCIS , ISKANDER MAGDY NAGUIB , DANYLEC BASIL
- 申请人： CORTICAL PTY LTD
- 专利权人： CORTICAL PTY LTD
- 当前专利权人： CORTICAL PTY LTD
- 优先权： AUPS283302 2002-06-07; AUPS283402 2002-06-07
- 主分类号： A61K31/075
- IPC分类号： A61K31/075 ; A61K31/12 ; A61K31/185 ; A61K31/192 ; A61K31/205 ; A61K31/216 ; A61K31/255 ; A61K31/277 ; A61K31/357 ; A61K31/4184 ; A61K31/585 ; A61P25/00 ; A61P29/00 ; A61P31/00 ; A61P35/00 ; A61P37/00 ; A61P43/00 ; C07C43/205 ; C07C43/225 ; C07C43/23 ; C07C45/00 ; C07C45/46 ; C07C49/84 ; C07C57/50 ; C07C59/58 ; C07C65/24 ; C07C65/28 ; C07C69/76 ; C07C69/94 ; C07C205/59 ; C07C211/57 ; C07C215/50 ; C07C219/22 ; C07C229/70 ; C07C255/37 ; C07C309/47 ; C07C309/60 ; C07C309/75 ; C07C323/43 ; C07C333/04 ; C07D235/26 ; C07D307/83 ; C07D319/18 ; C07D319/22 ; C07D403/12 ; C07H13/10
摘要：
Where Y, R 1 -R 8 and R 101 -R 108 are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (1), either alone or as part of a combination therapy.
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