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1.发明公开NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) 审中-公开萘衍生物; 细胞因子或生物AKTIVITûT迁移抑制因子的巨噬细胞抑制（MIF）
公开(公告)号：EP1549598A4
公开(公告)日：2008-01-23
申请号：EP03724672
申请日：2003-06-06
申请人： CORTICAL PTY LTD
IPC分类号： A61K31/075 , A61K31/12 , A61K31/185 , A61K31/192 , A61K31/205 , A61K31/216 , A61K31/255 , A61K31/277 , A61K31/357 , A61K31/4184 , A61K31/585 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C43/205 , C07C43/225 , C07C43/23 , C07C45/00 , C07C45/46 , C07C49/84 , C07C57/50 , C07C59/58 , C07C65/24 , C07C65/28 , C07C69/76 , C07C69/94 , C07C205/59 , C07C211/57 , C07C215/50 , C07C219/22 , C07C229/70 , C07C255/37 , C07C309/47 , C07C309/60 , C07C309/75 , C07C323/43 , C07C333/04 , C07D235/26 , C07D307/83 , C07D319/18 , C07D319/22 , C07D403/12 , C07H13/10
CPC分类号： C07D403/12 , A61K31/4184 , A61K31/585 , C07C43/225 , C07C43/23 , C07C45/004 , C07C45/46 , C07C59/58 , C07C65/24 , C07C65/28 , C07C69/94 , C07C205/59 , C07C229/70 , C07C255/37 , C07C309/60 , C07C309/75 , C07C333/04 , C07D235/26 , C07D307/83 , C07D319/18 , C07H13/10 , C07C47/575 , C07C49/84
摘要： Where Y, R 1 -R 8 and R 101 -R 108 are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (1), either alone or as part of a combination therapy.
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公开(公告)号：EP1511736A4
公开(公告)日：2006-06-07
申请号：EP03727010
申请日：2003-06-06
申请人： CORTICAL PTY LTD
IPC分类号： C07D235/26 , A61K31/4184 , A61K31/57 , A61K31/585 , A61K31/7024 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/02 , A61P5/14 , A61P7/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/16 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/28 , A61P27/02 , A61P27/12 , A61P29/00 , A61P33/06 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07C43/225 , C07C43/23 , C07C45/00 , C07C45/46 , C07C59/58 , C07C65/24 , C07C65/28 , C07C69/94 , C07C205/59 , C07C229/70 , C07C255/37 , C07C309/60 , C07C309/75 , C07C333/04 , C07D235/28 , C07D263/58 , C07D307/83 , C07D319/18 , C07D403/12 , C07H13/10
CPC分类号： C07D403/12 , A61K31/4184 , A61K31/585 , C07C43/225 , C07C43/23 , C07C45/004 , C07C45/46 , C07C59/58 , C07C65/24 , C07C65/28 , C07C69/94 , C07C205/59 , C07C229/70 , C07C255/37 , C07C309/60 , C07C309/75 , C07C333/04 , C07D235/26 , C07D235/28 , C07D263/58 , C07D307/83 , C07D319/18 , C07H13/10 , C07C47/575 , C07C49/84
摘要： Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) as defined herein, is provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as part of a combination therapy. Novel heterocyclic compounds are also provided for.
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