发明授权
- 专利标题： BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE
- 专利标题（中）： 苯并咪唑和苯并噻唑作为地图激酶抑制剂
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申请号： EP03784749.8申请日： 2003-07-31
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公开(公告)号： EP1554272B1公开(公告)日： 2006-10-25
- 发明人: BONJOUKLIAN, Rosanne , DE DIEGO GOMEZ, Jose, Eugenio Lilly, S. A. , DE DIOS, Alfonso Lilly, S. A. , HAMDOUCHI, Chafiq, Hamdouchi , LI, Tiechao , LOPEZ DE URALDE GARMENDIA, Beatriz Lilly, S. A. , VIETH, Michal , YORK, Jeremy, Schulenburg , DALLY, Robert, Dean , DEL PRADO CATALINA, Miriam, Filadelfa Lilly, S. A. , JARAMILLO, Carlos Lilly, S. A. , MARTIN CABREJAS, Luisa, Maria Lilly, S. A. , MONTERO SALGADO, Carlos Lilly, S. A. , PLEITE, Sheila Lilly, S. A. , SANCHEZ-MARTINEZ, Concepcion Lilly, S. A. , SHEPHERD, Timothy, Alan , WIKEL, James, Howard
- 申请人： ELI LILLY AND COMPANY
- 申请人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 代理机构： Burnside, Ivan John
- 优先权： EP02380178 20020809; US421939P 20021028
- 国际公布： WO2004014900 20040219
- 主分类号： C07D409/14
- IPC分类号： C07D409/14 ; C07D403/04 ; C07D401/14 ; C07D405/14 ; C07D403/14 ; C07D413/14 ; C07D471/04 ; C07D487/04 ; C07D409/04 ; C07D417/04 ; A61K31/41 ; A61P35/04
摘要：
The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis.
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