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公开(公告)号：EP1019045A1
公开(公告)日：2000-07-19
申请号：EP98932921.4
申请日：1998-06-26
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , KYLE, Jeffrey, Alan , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , WILEY, Michael, Robert
IPC分类号： A61K31/40 , A61K31/41 , A61K31/415 , A61K31/445 , A61K31/495 , A61K31/505 , C07D209/04 , C07D209/12 , C07D209/18 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D249/16 , C07D401/12 , C07D403/12 , C07D409/12
CPC分类号： C07D401/14 , C07D209/08 , C07D209/30 , C07D231/56 , C07D235/06 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1554272A1
公开(公告)日：2005-07-20
申请号：EP03784749.8
申请日：2003-07-31
发明人： BONJOUKLIAN, Rosanne , DE DIEGO GOMEZ, Jose, EugenioLilly, S. A. , DE DIOS, AlfonsoLilly, S. A. , HAMDOUCHI, Chafiq, Hamdouchi , LI, Tiechao , LOPEZ DE URALDE GARMENDIA, BeatrizLilly, S. A. , VIETH, Michal , YORK, Jeremy, Schulenburg , DALLY, Robert, Dean , DEL PRADO CATALINA, Miriam, FiladelfaLilly, S. A. , JARAMILLO, CarlosLilly, S. A. , MARTIN CABREJAS, Luisa, MariaLilly, S. A. , MONTERO SALGADO, CarlosLilly, S. A. , PLEITE, SheilaLilly, S. A. , SANCHEZ-MARTINEZ, ConcepcionLilly, S. A. , SHEPHERD, Timothy, Alan , WIKEL, James, Howard
IPC分类号： C07D409/14 , C07D403/04 , C07D401/14 , C07D405/14 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D409/04 , C07D417/04 , A61K31/41 , A61P35/04
CPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D513/04
摘要： The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis.
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公开(公告)号：EP1007037A1
公开(公告)日：2000-06-14
申请号：EP98932926.3
申请日：1998-06-26
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： A61K31/38 , A61K31/40 , A61K31/42 , A61K31/165 , A61K31/445 , C07C233/64 , C07D209/44 , C07D211/32 , C07D333/06
CPC分类号： C07C271/66 , A61K31/00 , C07C257/18 , C07C259/18 , C07C271/64 , C07D209/44 , C07D211/60 , C07D261/20 , C07D333/38
摘要： This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1140905B1
公开(公告)日：2003-05-14
申请号：EP99967352.8
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong , KYLE,Jeffrey , Wiley,Michael
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D405/14 , C07D213/82 , A61K31/4545 , A61K31/4427 , A61P7/02
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14
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公开(公告)号：EP1140905A1
公开(公告)日：2001-10-10
申请号：EP99967352.8
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan, Pariyadan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D405/14 , C07D213/82 , A61K31/4545 , A61K31/4427 , A61P7/02
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14
摘要： This application relates to heteroaromatic amides (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP0999834B1
公开(公告)日：2005-10-12
申请号：EP98932911.5
申请日：1998-06-26
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , KYLE, Jeffrey, Alan , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： A61K31/38 , A61K31/40 , A61K31/44 , A61K31/495 , A61K31/505 , C07D209/30 , C07D209/40 , C07D213/75 , C07D213/81 , C07D213/82 , C07D333/38 , C07D209/42
CPC分类号： C07D213/75 , A61K31/44 , C07D209/42 , C07D333/38
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公开(公告)号：EP1019045B1
公开(公告)日：2005-06-08
申请号：EP98932921.4
申请日：1998-06-26
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , KYLE, Jeffrey, Alan , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , WILEY, Michael, Robert
IPC分类号： A61K31/40 , A61K31/41 , A61K31/415 , A61K31/445 , A61K31/495 , A61K31/505 , C07D209/04 , C07D209/12 , C07D209/18 , C07D231/56 , C07D209/08 , C07D235/08 , C07D249/18 , C07D409/12 , C07D403/12 , C07D401/12 , C07D209/30 , C07D403/14 , C07D401/14
CPC分类号： C07D401/14 , C07D209/08 , C07D209/30 , C07D231/56 , C07D235/06 , C07D401/12 , C07D403/12 , C07D409/12
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公开(公告)号：EP1140881A1
公开(公告)日：2001-10-10
申请号：EP99964269.7
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong
IPC分类号： C07D295/12 , C07D401/04 , C07D401/12 , C07D409/14 , C07D401/14 , A61K31/44 , A61K31/445
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1554272B1
公开(公告)日：2006-10-25
申请号：EP03784749.8
申请日：2003-07-31
发明人： BONJOUKLIAN, Rosanne , DE DIEGO GOMEZ, Jose, Eugenio Lilly, S. A. , DE DIOS, Alfonso Lilly, S. A. , HAMDOUCHI, Chafiq, Hamdouchi , LI, Tiechao , LOPEZ DE URALDE GARMENDIA, Beatriz Lilly, S. A. , VIETH, Michal , YORK, Jeremy, Schulenburg , DALLY, Robert, Dean , DEL PRADO CATALINA, Miriam, Filadelfa Lilly, S. A. , JARAMILLO, Carlos Lilly, S. A. , MARTIN CABREJAS, Luisa, Maria Lilly, S. A. , MONTERO SALGADO, Carlos Lilly, S. A. , PLEITE, Sheila Lilly, S. A. , SANCHEZ-MARTINEZ, Concepcion Lilly, S. A. , SHEPHERD, Timothy, Alan , WIKEL, James, Howard
IPC分类号： C07D409/14 , C07D403/04 , C07D401/14 , C07D405/14 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D409/04 , C07D417/04 , A61K31/41 , A61P35/04
CPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D513/04
摘要： The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis.
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公开(公告)号：EP1140881B1
公开(公告)日：2006-05-17
申请号：EP99964269.7
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong , Kyle, Jefferey.A
IPC分类号： C07D295/12 , C07D401/04 , C07D401/12 , C07D409/14 , C07D401/14 , A61K31/44 , A61K31/445
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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