发明公开
- 专利标题： USE OF NITRITE SALTS FOR THE TREATMENT OF CARDIOVASCULAR CONDITIONS
- 专利标题（中）： 亚硝酸盐对心血管疾病治疗
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申请号： EP04777982.2申请日： 2004-07-09
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公开(公告)号： EP1648475A2公开(公告)日： 2006-04-26
- 发明人: GLADWIN, Mark, T. , SCHECHTER, Alan, N. , LEFER, David, J. , PATEL, Rakesh, P. , HUNTER, Christian J., National Inst. of Health , POWER, Gordon, G. , KIM-SHAPIRO, Daniel, B. , PLUTA, Ryszard National Institutes of Health NINDS , OLDFIELD, Edward, H.
- 申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , UNIVERSITY OF ALABAMA RESEARCH FOUNDATION , LOMA LINDA UNIVERSITY , WAKE FOREST UNIVERSITY
- 申请人地址： The National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852 US
- 专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE,UNIVERSITY OF ALABAMA RESEARCH FOUNDATION,LOMA LINDA UNIVERSITY,WAKE FOREST UNIVERSITY
- 当前专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE,UNIVERSITY OF ALABAMA RESEARCH FOUNDATION,LOMA LINDA UNIVERSITY,WAKE FOREST UNIVERSITY
- 当前专利权人地址： The National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852 US
- 代理机构： Walton, Seán Malcolm
- 优先权： US485959P 20030709; US511244P 20031014
- 国际公布： WO2005004884 20050120
- 主分类号： A61K33/00
- IPC分类号： A61K33/00 ; A61P9/08 ; A61P9/10 ; A61P9/12
摘要：
It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
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