公开(公告)号：EP1648475B1

公开(公告)日：2007-09-12

申请号：EP04777982.2

申请日：2004-07-09

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE ,  UNIVERSITY OF ALABAMA RESEARCH FOUNDATION ,  LOMA LINDA UNIVERSITY ,  WAKE FOREST UNIVERSITY

发明人： GLADWIN, Mark, T. ,  SCHECHTER, Alan, N. ,  LEFER, David, J. ,  PATEL, Rakesh, P. ,  HUNTER, Christian J., National Inst. of Health ,  POWER, Gordon, G. ,  KIM-SHAPIRO, Daniel, B. ,  PLUTA, Ryszard National Institutes of Health NINDS ,  OLDFIELD, Edward, H. ,  CANNON III, Richard, O.

IPC分类号： A61K33/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

公开(公告)号：EP1648475A2

公开(公告)日：2006-04-26

申请号：EP04777982.2

申请日：2004-07-09

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE ,  UNIVERSITY OF ALABAMA RESEARCH FOUNDATION ,  LOMA LINDA UNIVERSITY ,  WAKE FOREST UNIVERSITY

发明人： GLADWIN, Mark, T. ,  SCHECHTER, Alan, N. ,  LEFER, David, J. ,  PATEL, Rakesh, P. ,  HUNTER, Christian J., National Inst. of Health ,  POWER, Gordon, G. ,  KIM-SHAPIRO, Daniel, B. ,  PLUTA, Ryszard National Institutes of Health NINDS ,  OLDFIELD, Edward, H.

IPC分类号： A61K33/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.