公开(公告)号：EP1648475B1

公开(公告)日：2007-09-12

申请号：EP04777982.2

申请日：2004-07-09

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE ,  UNIVERSITY OF ALABAMA RESEARCH FOUNDATION ,  LOMA LINDA UNIVERSITY ,  WAKE FOREST UNIVERSITY

发明人： GLADWIN, Mark, T. ,  SCHECHTER, Alan, N. ,  LEFER, David, J. ,  PATEL, Rakesh, P. ,  HUNTER, Christian J., National Inst. of Health ,  POWER, Gordon, G. ,  KIM-SHAPIRO, Daniel, B. ,  PLUTA, Ryszard National Institutes of Health NINDS ,  OLDFIELD, Edward, H. ,  CANNON III, Richard, O.

IPC分类号： A61K33/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

公开(公告)号：EP1648475A2

公开(公告)日：2006-04-26

申请号：EP04777982.2

申请日：2004-07-09

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE ,  UNIVERSITY OF ALABAMA RESEARCH FOUNDATION ,  LOMA LINDA UNIVERSITY ,  WAKE FOREST UNIVERSITY

发明人： GLADWIN, Mark, T. ,  SCHECHTER, Alan, N. ,  LEFER, David, J. ,  PATEL, Rakesh, P. ,  HUNTER, Christian J., National Inst. of Health ,  POWER, Gordon, G. ,  KIM-SHAPIRO, Daniel, B. ,  PLUTA, Ryszard National Institutes of Health NINDS ,  OLDFIELD, Edward, H.

IPC分类号： A61K33/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

公开(公告)号：EP1653978A1

公开(公告)日：2006-05-10

申请号：EP04756810.0

申请日：2004-07-09

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： GLADWIN, Mark, T. ,  CANNON, Richard III ,  SCHECHTER, Alan, N.

IPC分类号： A61K33/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

摘要翻译： 已经令人惊讶地发现，向受试者施用亚硝酸盐导致血压降低和血液向组织的增加。 该效果对于例如低氧张力区域的组织是特别有益的。 该发现提供了有用的治疗方法来调节受试者的血压和血流量，例如通过施用亚硝酸盐。 本文提供了向受试者施用药学上可接受的亚硝酸盐，用于治疗，预防或改善选自以下的病症的方法：（a）缺血再灌注损伤（例如肝脏或心脏或脑缺血 - 再灌注损伤）; （b）肺动脉高压（如新生儿肺动脉高压）; 或（c）大脑动脉血管痉挛。